Fungal colonization and/or infection in non-neutropenic critically ill patients: Results of the EPCAN observational study

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 28, Issue 3, 2009, Pages 233-242

  Leon C ^a   Alvarez Lerma F ^b   Ruiz Santana, S ^c   Leon M A ^d   Nolla, J ^b   Jorda R ^e   Saavedra, P ^f   Palomar, M ^g  

^a HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^d HOSPITAL GENERAL DE CATALUNYA   (Spain)

^e Clinica Rotger   (Spain)

^f UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^g UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CANDIDA; CANDIDIASIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; FEMALE; FUNGAL COLONIZATION; HUMAN; HUMAN TISSUE; INFECTION RISK; INTENSIVE CARE UNIT; INVASIVE CANDIDIASIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; PRIORITY JOURNAL; SEPSIS; TOTAL PARENTERAL NUTRITION;

ADULT; AGED; COHORT STUDIES; CRITICAL ILLNESS; FEMALE; FUNGI; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYCOSES; PROSPECTIVE STUDIES; RISK FACTORS; SPAIN;

EID: 61349151676     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10096-008-0618-z     Document Type: Article

References (33)

1. CM Beck-Sagué WR Jarvis 1993 Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System J Infect Dis 167 1247 1251
2. WR Jarvis 1995 Epidemiology of nosocomial fungal infections, with emphasis on Candida species Clin Infect Dis 20 1526 1530
3. D Pittet RP Wenzel 1995 Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths Arch Intern Med 155 1177 1184
4. MA Pfaller RN Jones GV Doern HS Sader RJ Hollis SA Messer 1998 International surveillance of bloodstream infections due to Candida species: frequency of occurrence and antifungal susceptibilities of isolates collected in 1997 in the United States, Canada, and South America for the SENTRY Program. The SENTRY Participant Group J Clin Microbiol 36 1886 1889
5. JL Vincent DJ Bihari PM Suter HA Bruining J White MH Nicolas-Chanoin 1995 The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee JAMA 274 639 644
6. HM Blumberg WR Jarvis JM Soucie JE Edwards JE Patterson MA Pfaller 2001 Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. The National Epidemiology of Mycosis Survey Clin Infect Dis 33 177 186
7. F Álvarez-Lerma M Palomar P Olaechea JJ Otal J Insausti E Cerdá Grupo de Estudio de Vigilacia de Infección Nosocomial en UCI 2007 National Study of Control of Nosocomial Infection in Intensive Care Units. Evolutive report of the years 2003-2005 Med Intensiva 31 6 17
8. JL Vincent E Anaissie H Bruining W Demajo M el-Ebiary J Haber 1998 Epidemiology, diagnosis and treatment of systemic Candida infection in surgical patients under intensive care Intensive Care Med 24 206 216
9. F Álvarez-Lerma M Palomar C León P Olaechea E Cerdá B Bermejo Grupo de Estudio de Infeción Fúngica 2003 Fungal colonization and/or infection in intensive care units. Multicenter study of 1,562 patients Med Clin (Barc) 121 161 166
10. SB Wey M Mori MA Pfaller RF Woolson RP Wenzel 1988 Hospital-acquired candidemia. The attributable mortality and excess length of stay Arch Intern Med 148 2642 2645
11. D Pittet D Tarara RP Wenzel 1994 Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality JAMA 271 1598 15601
12. F Álvarez-Lerma J Nolla-Salas C León M Palomar R Jordá N Carrasco EPCAN Study Group 2003 Candiduria in critically ill patients admitted to intensive care medical units Intensive Care Med 29 1069 1076
13. American College of Chest Physicians/Society of Critical Care Medicine 1992 Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 20 864 874
14. Centers for Disease Control 1992 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults MMWR Recomm Rep 41 RR-17 1 19
15. JW Hurst DC Morris RW Alexander 1999 The use of the New York Heart Association's classification of cardiovascular disease as part of the patient's complete Problem List Clin Cardiol 22 385 390
16. WA Knaus EA Draper DP Wagner JE Zimmerman 1985 APACHE II: a severity of disease classification system Crit Care Med 13 818 829
17. MG Petri J König HP Moecke HJ Gramm H Barkow P Kujath 1997 Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients Intensive Care Med 23 317 325
18. D Pittet M Monod PM Suter E Frenk R Auckenthaler 1994 Candida colonization and subsequent infections in critically ill surgical patients Ann Surg 220 751 758
19. B De Pauw TJ Walsh JP Donnelly DA Stevens JE Edwards T Calandra 2008 Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Clin Infect Dis 46 1813 1821
20. SS Magill SM Swoboda EA Johnson WG Merz RK Pelz PA Lipsett 2006 The association between anatomic site of Candida colonization, invasive candidiasis, and mortality in critically ill surgical patients Diagn Microbiol Infect Dis 55 293 301
21. JK Chow Y Golan R Ruthazer AW Karchmer Y Carmeli D Lichtenberg 2008 Factors associated with candidemia caused by non-albicans Candida species versus Candida albicans in the intensive care unit Clin Infect Dis 46 1206 1213
22. MH Nguyen JE Peacock Jr AJ Morris DC Tanner ML Nguyen DR Snydman 1996 The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance Am J Med 100 617 623
23. MA Pfaller DJ Diekema RN Jones HS Sader AC Fluit RJ Hollis SENTRY Participant Group 2001 International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program J Clin Microbiol 39 3254 3259
24. SB Wey M Mori MA Pfaller RF Woolson RP Wenzel 1989 Risk factors for hospital-acquired candidemia. A matched case-control study Arch Intern Med 149 2349 2353
25. E Diaz A Villagrá J Rello J Vallés Grupo de Estudio de Bacteriemias en ICU 1999 Factores de riesgo de candidemia nosocomial en cuidados intensivos Med Intensiva 23 25 31
26. A Karabinis C Hill B Leclercq C Tancrède D Baume A Andremont 1988 Risk factors for candidemia in cancer patients: a case-control study J Clin Microbiol 26 429 432
27. VJ Fraser M Jones J Dunkel S Storfer G Medoff WC Dunagan 1992 Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality Clin Infect Dis 15 414 421
28. T Calandra J Bille R Schneider F Mosimann P Francioli 1989 Clinical significance of Candida isolated from peritoneum in surgical patients Lancet 2 1437 1440
29. PE Charles F Dalle H Aube JM Doise JP Quenot LS Aho 2005 Candida spp. colonization significance in critically ill medical patients: a prospective study Intensive Care Med 31 393 400
30. J Garbino DP Lew JA Romand S Hugonnet R Auckenthaler D Pittet 2002 Prevention of severe Candida infections in nonneutropenic, high-risk, critically ill patients: a randomized, double-blind, placebo-controlled trial in patients treated by selective digestive decontamination Intensive Care Med 28 1708 1717
31. C León S Ruiz-Santana P Saavedra B Almirante J Nolla-Salas F Álvarez-Lerma EPCAN Study Group 2006 A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization Crit Care Med 34 730 737
32. D Pittet N Li RP Wenzel 1993 Association of secondary and polymicrobial nosocomial bloodstream infections with higher mortality Eur J Clin Microbiol Infect Dis 12 813 819
33. R Jordà-Marcos F Álvarez-Lerma M Jurado M Palomar J Nolla-Salas MA León EPCAN Study Group 2007 Risk factors for candidaemia in critically ill patients: a prospective surveillance study Mycoses 50 302 310