Mapping the active site in a chemzyme: Diversity in the N-substituent in the catalytic asymmetric aziridination of imines

Organic Letters

Volumn 10, Issue 23, 2008, Pages 5429-5432

  Zhang, Yu ^a   Lu, Zhenjie ^a   Desai, Aman ^a   Wulff, William D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE; AZIRIDINE DERIVATIVE; IMINE; NAPHTHALENE DERIVATIVE; NITROGEN; VANOL LIGAND;

ARTICLE; CATALYSIS; CHEMISTRY; CONFORMATION; ELECTRON; ENZYME ACTIVE SITE;

AZIRIDINES; CATALYSIS; CATALYTIC DOMAIN; ELECTRONS; IMINES; MOLECULAR CONFORMATION; NAPHTHALENES; NITROGEN;

EID: 61349143080     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol802431v     Document Type: Article

References (24)

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22. The relative rates were determined as described in Figure 2.
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24. A catalyst (10 mol %) prepared from (S)-BINOL according to the protocol in Scheme 1 will catalyze the AZ reaction of imine 1p to give aziridine 3p in 71% yield and 67% ee under the conditions shown in Scheme 1.