Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 2091-2100

  Wang, Yanong D ^a   Honores, Erick ^a   Wu, Biqi ^a   Johnson, Steve ^a   Powell, Dennis ^a   Miranda, Miriam ^a   McGinnis, John P ^a   Discafani, Carolyn ^a   Rabindran, Sridhar K ^a   Cheng, Wendy ^a   Krishnamurthy, Girija ^a  

^a WYETH RESEARCH   (United States)

Author keywords

Anti proliferative activity; Checkpoint deficiency; Microtubulin binding; p21 Deficient cells; Pyrazolo 1,5 a pyrimidine

Indexed keywords

AMIDE; ANTIMETASTATIC AGENT; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; DNA; N [2 FLUORO 5 [3 (2 THIENYLCARBONYL)PYRAZOLO[1,5 A]PYRIMIDIN 7 YL]PHENYL] 3 METHYLBUTANAMIDE; PROTEIN P53; PYRAZOLO[1,5 A]PYRIMIDIN 7 YL PHENYL AMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; XENOGRAFT;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; HUMANS; MICE; MICE, NUDE; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 61349104495     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.046     Document Type: Article

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