Dibasic benzo[b]thiophene derivatives as a novel class of active site- directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3489-3493

  Sall, D J ^a   Bastian, J A ^a   Briggs, S L ^a   Buben, J A ^a   Chirgadze, N Y ^a   Clawson, D K ^a   Denney, M L ^a   Giera, D D ^a   Gifford Moore, D S ^a   Harper, R W ^a   Hauser, K L ^a   Klimkowski, V J ^a   Kohn, T J ^a   Lin, H S ^a   McCowan, J R ^a   Palkowitz, A D ^a   Smith, G F ^a   Takeuchi, K ^a   Thrasher, K J ^a   Tinsley, J M ^a   Utterback, B G ^a   Yan, S C B ^a   Zhang, M ^a   more..

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BENZOTHIOPHENE DERIVATIVE; THROMBIN INHIBITOR;

ANTICOAGULATION; ARTICLE; DRUG CONFORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; STRUCTURE ACTIVITY RELATION; THROMBOSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; THROMBIN;

EID: 0030693872     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9704107     Document Type: Article

References (22)