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8
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27744483875
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Synthesis of vinylaziridines from α,β-unsaturated aldehydes and the application towards synthesis of sphingosine were also reported:
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Synthesis of vinylaziridines from α,β-unsaturated aldehydes and the application towards synthesis of sphingosine were also reported:. Disadee W., and Ishikawa T. J. Org. Chem. 70 (2005) 9399
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61349112450
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For examples of epimerization during the reaction course of aziridination
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For examples of epimerization during the reaction course of aziridination:
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46
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0037047569
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2,3-Cis isomer bearing tetrahedral structure on the aziridine nitrogen were reported to be preferable rather than 2,3-trans isomer:
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2,3-Cis isomer bearing tetrahedral structure on the aziridine nitrogen were reported to be preferable rather than 2,3-trans isomer:. Miura N., Miwa Y., Ibuka T., and Yamamoto Y. J. Org. Chem. 67 (2002) 5796
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61349162072
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5 Conditions: column: DAICEL CHIRALCEL AD-H, solvent: hexane : 2-propanol = 50 : 1, rate: 1.0 mL/min, detection: 254 nm. Retention time: (2R,3R)-cis-1d: 6.5 min (major), 11.6 min (minor); cis-1a in this experiment: 11.4 min (major), 15.2 min (minor).
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5 Conditions: column: DAICEL CHIRALCEL AD-H, solvent: hexane : 2-propanol = 50 : 1, rate: 1.0 mL/min, detection: 254 nm. Retention time: (2R,3R)-cis-1d: 6.5 min (major), 11.6 min (minor); cis-1a in this experiment: 11.4 min (major), 15.2 min (minor).
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49
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61349135177
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2O or acetic acid at -78 °C) showed no epimerization.
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2O or acetic acid at -78 °C) showed no epimerization.
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