Hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii as a new type of anti-diabetic compound

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 255-261

  Zhang, Hailong ^a   Matsuda, Hisashi ^a   Yamashita, Chihiro ^a   Nakamura, Seikou ^a   Yoshikawa, Masayuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

3T3 L1 cell; Adiponectin; Anti diabetic compound; Hydrangea macrophylla var. thunbergii; Hydrangeic acid; KK Ay mouse

Indexed keywords

3' HYDROXYHYDRANGEIC ACID; ADIPONECTIN; ANTIDIABETIC AGENT; CELL NUCLEUS RECEPTOR; DEOXYGLUCOSE; DIHYDROPICEATANNOL; FATTY ACID; FATTY ACID BINDING PROTEIN 2; GLUCOSE; GLUCOSE TRANSPORTER 4; HERBACEOUS AGENT; HYDRANGEIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PICEATANNOL; RESVERATROL; RHAPONTIGENIN; RHAPONTIN; STILBENE DERIVATIVE; TRIACYLGLYCEROL; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; C57BL 6 MOUSE; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG STRUCTURE; FATTY ACID BLOOD LEVEL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYDRANGEA MACROPHYLLA; KNOCKOUT MOUSE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL;

3T3-L1 CELLS; ADIPOGENESIS; ADIPONECTIN; ANIMALS; BIOLOGICAL TRANSPORT; DEOXYGLUCOSE; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 4; HYDRANGEA; HYPOGLYCEMIC AGENTS; MALE; MICE; NITRIC OXIDE; PLANT LEAVES; PPAR GAMMA; SALICYLIC ACIDS; STILBENES; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 60949107119     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.005     Document Type: Article

References (22)

1. Aoyagi T., Shimba S., and Tezuka M. Characteristics of circadian gene expressions in mice white adipose tissue and 3T3-L1 adipocytes. J. Health Sci. 51 (2005) 21-32
2. Ajuwon K.M., and Spurlock M.E. Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 (2005) R1220-R1225
3. Chang F., Jaber L.A., Berlie H.D., and O'Connell M.B. Evolution of peroxisome proliferator-activated receptor agonists. Ann. Pharmacother. 41 (2007) 973-983
4. Dobashi K., Asayama K., Nakane T., Kodera K., Hayashibe H., and Nakazawa S. Troglitazone inhibits the expression of inducible nitric oxide synthase in adipocytes in vitro and in vivo: Study in 3T3-L1 cells and Otsuka Long-Evans Tokushima Fatty rats. Life Sci. 67 (2000) 2093-2101
5. Han K.L., Jung M.H., Sohn J.H., and Hwang J.K. Ginsenoside 20(S)-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor γ (PPARγ) in 3T3-L1 adipocytes. Biol. Pharm. Bull. 29 (2006) 110-113
6. Henness S. Pharmacological interventions in the prevention of type 2 diabetes. Curr. Opin. Endocrinol. Diabetes Obes. 14 (2007) 166-169
7. Herman J.R., Dethloff L.A., McGuire E.J., Parker R.F., Walsh K.M., Gough A.W., Masuda H., and de la Iglesia F.A. Rodent carcinogenicity with the thiazolidinedione antidiabetic agent trogitazone. Toxicol. Sci. 68 (2002) 226-236
8. Huang J., Imamura T., Babendure J.L., Lu J.C., and Olefsky J.M. Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes. J. Biochem. 280 (2005) 42300-42306
9. Iwaki M., Matsuda M., Maeda N., Funahashi T., Matsuzawa Y., Makishima M., and Shimomura I. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52 (2003) 1655-1663
10. Kadowaki T., and Yamauchi T. Adiponectin and adiponectin receptor. Endocr. Rev. 26 (2005) 439-451
11. Kudo M., Sugawara A., Uruno A., Takeuchi K., and Ito S. Transcription suppression of peroxisome proliferator-activated receptor γ2 gene expression by tumor necrosis factor α via an inhibition of CCAAT/enhancer-binding protein δ during the early stage of adipocyte differentiation. Endocrinology 145 (2004) 4948-4956
12. Matsuda H., Morikawa T., Toguchida I., Park J.Y., Harima S., and Yoshikawa M. Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides. Bioorg. Med. Chem. 9 (2001) 41-50
13. McClain D.A., Hazel M., Parker G., and Cooksey R.C. Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid. Am. J. Physiol. Endocrinol. Metab. 288 (2005) E973-E979
14. Parker J.C. Troglitazone: the discovery and development of a novel therapy for the treatment of type 2 diabetes mellitus. Adv. Drug Deliv. Rev. 54 (2002) 1173-1197
15. Rayalam S., Della-Fera M.A., Yang J.Y., Park H.J., Ambati S., and Baile C.A. Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes. J. Nutr. 137 (2007) 2668-2673
16. 1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARγ2 and C/EBPα gene expression. Life Sci. 80 (2007) 618-625
17. Tafuri S.R. Troglitazone enhances differentiation, basal glucose uptake, and GLUT1 protein levels in 3T3-L1 adipocytes. Endocrinology 137 (1996) 4706-4712
18. Tontonoz P., Hu E., Graves R.A., Budavari A.I., and Spiegelman B.M. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8 (1994) 1224-1234
19. Tsuchida A., Yamauchi T., and Kadowaki T. Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor γ, CREB-binding protein, and adiponectin. J. Pharmacol. Sci. 97 (2005) 164-170
20. Yang J.Y., Della-Fera M.A., Rayalam S., Ambati S., Hartzell D.L., Park H.J., and Baile C.A. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 82 (2008) 1032-1039
21. Yoshikawa M., Shimada H., Yagi N., Murakami N., Shimoda H., Yamahara J., and Matsuda H. Development of bioactive functions in Hydrangeae Dulcis Folium. VI. Synthesis of thunberginols A and F and their 3′-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: structures and inhibitory activity on histamine release of hydramacrophyllols A and B. Chem. Pharm. Bull. 44 (1996) 1890-1898
22. Zhang H., Matsuda H., Kumahara A., Ito Y., Nakamura S., and Yoshikawa M. New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Bioorg. Med. Chem. Lett. 17 (2007) 4972-4976