Nonlinear effects in proline-catalysed aldol reactions under solvent-free conditions based on the ternary phase behaviour of scalemic proline

CrystEngComm

Volumn 11, Issue 3, 2009, Pages 404-407

  Bruckmann, Angelika ^a   Rodríguez, Belén ^a   Bolm, Carsten ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

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Indexed keywords

EID: 60849136349     PISSN: 14668033     EISSN: 14668033     Source Type: Journal    
DOI: 10.1039/b821415h     Document Type: Article

References (37)

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36. p-Nitrobenzaldehyde was sublimated twice, and proline was recrystallized from EtOH before use. Cyclohexanone was freshly distilled
37. Here, the aldol product ee was determined as a function of conversion (reaction time). Exemplarily, a total proline ee of 40% was chosen. After 4 h reaction time a conversion of 22% and an aldol product ee of 26% were detected. The corresponding aldol product ees for a conversion of 37% (6 h), 39% (8 h), 68% (16 h) and 82% (24 h) were found to be 31, 32, 51 and 52%, respectively. For unknown reasons the final aldol product ee was higher than in the previous study