Practical synthesis of a p38 MAP kinase inhibitor

Journal of Organic Chemistry

Volumn 74, Issue 2, 2009, Pages 795-809

  Achmatowicz, Michał ^a   Thiel, Oliver R ^a   Wheeler, Philip ^a   Bernard, Charles ^a   Huang, Jinkun ^a   Larsen, Robert D ^a   Faul, Margaret M ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORONIC ACIDS; BUILDING BLOCKS; EFFICIENT SYNTHESIS; INFLAMMATORY DISEASE; MAP KINASE; ONE POTS; PHTHALAZINE; SYNTHETIC ROUTES;

4 CHLOROBENZOIC ACID; BENZAMIDE DERIVATIVE; BENZOIC ACID; BORONIC ACID DERIVATIVE; IODINE; LITHIUM DERIVATIVE; MAGNESIUM; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MORPHOLINE; PHTHALAZINE DERIVATIVE; AMIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MORPHOLINE DERIVATIVE; PHTHALAZINE; PROTEIN KINASE INHIBITOR;

AMIDATION; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HYDROXYLATION; PROTON TRANSPORT; SUZUKI REACTION; CHEMISTRY; DRUG ANTAGONISM; SYNTHESIS;

AMIDES; BENZOIC ACID; MORPHOLINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHTHALAZINES; PROTEIN KINASE INHIBITORS;

EID: 60849134008     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo802186m     Document Type: Article

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63. 3 reaction conditions.
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