Hypoglycaemic effect of mollic acid glucoside, a 1α- hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf, in rodents

Journal of Natural Medicines

Volumn 63, Issue 2, 2009, Pages 117-123

  Ojewole, John A O ^a   Adewole, Stephen O ^a  

^a University of KwaZulu Natal Faculty of Health Sciences   (South Africa)

Author keywords

Combretum molle leaf; Hypoglycaemic and antidiabetic properties; Mollic acid glucoside

Indexed keywords

COMBRETUM MOLLE EXTRACT; GLIBENCLAMIDE; GLUCOSE; INSULIN; MOLLIC ACID GLUCOSIDE; ORAL ANTIDIABETIC AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMBRETUM; COMBRETUM MOLLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG DOSE ESCALATION; FEMALE; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; LD 50; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANT LEAF; RAT; SOUTH AFRICA; STREPTOZOCIN DIABETES; TRADITIONAL MEDICINE; TREATMENT RESPONSE;

ANIMALS; COMBRETUM; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPOGLYCEMIC AGENTS; MALE; MEDICINE, AFRICAN TRADITIONAL; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SAPONINS; STREPTOZOCIN;

EID: 60849122217     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-008-0298-0     Document Type: Article

References (19)

1. SO Adewole JAO Ojewole 2007 Insulin-induced immunohistochemical and morphological changes in pancreatic β-cells of streptozotocin-treated diabetic rats Methods Find Exp Clin Pharmacol 29 447 455
2. Dunnett C, Goldsmith C (1993). In: Buncher CR, Tsay JY (eds) Statistics in pharmaceutical industry, 2nd edn. Marcel Dekker, New York
3. Hutchings A, Scott AH, Lewis G, Cunningham AB (1996) Zulu medicinal plants-an inventory. University of Natal Press, Pietermaritzburg
4. JE Jackson R Bressler 1981 Clinical pharmacology of sulphonylurea hypoglycaemic agents: part I Drugs 22 211 245
5. J Liu 1995 Pharmacology of oleanolic acid and ursolic acid J Ethnopharmacol 49 57 68
6. D Lorke 1983 A new approach to practical acute toxicity testing Arch Toxicol 54 275 287
7. RJ Marles NR Farnsworth 1995 Antidiabetic plants and their active constituents Phytomedicine 2 137 189
8. JAO Ojewole 2007 Analgesic, anti-inflammatory and hypoglycaemic effects of Rhus chirindensis (Baker F.) [Anacardiaceae] stem-bark aqueous extract in mice and rats J Ethnopharmacol 113 338 345
9. JAO Ojewole CO Adewunmi 2004 Anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera Taub (Fabaceae) fruit aqueous extract in rats J Ethnopharmacol 95 177 182
10. JAO Ojewole SE Drewes 2007 Hypoglycaemic effect of Eriosema kraussianum N. E. Br. [Fabaceae] rootstock hydro-alcohol extract in rats J Nat Med 61 244 250
11. JAO Ojewole SE Drewes F Khan 2006 Vasodilatory and hypoglycaemic effects of two pyrano-isoflavone extractives from Eriosema kraussianum N. E. Br. [Fabaceae] rootstock in experimental rat models Phytochemistry 67 610 617
12. KH Pegel CB Rogers 1976 Mollic acid 3-β-D-glucoside: A novel 1α-hydroxycycloartane saponin from Combretum molle (Combretaceae) Tetrahedron Lett 47 4299 4302
13. KH Pegel CB Rogers 1985 The characterization of mollic acid 3β-d-xyloside and its genuine aglycone mollic acid, two novel 1α-hydroxycyloartenoids from Combretum molle J Chem Soc, Perkin Trans 1 1711 1715
14. KH Pegel CB Rogers 1990 A review of triterpenoids extracted from the leaves of South African Combretum species Planta Med 56 548P
15. CB Rogers 1989 Isolation of 1α-hydroxycycloartenoid mollic acid and α-l-arabinoside from Combretum edwardsii leaves Phytochemistry 28 279 281
16. CB Rogers 1989 New mono- and bi-desmosidic triterpenoids isolated from Combretum padoides leaves J Nat Prod 52 528 533
17. CB Rogers I Thevan 1986 Identification of mollic acid α-l-arabinose, a 1α-hydroxycycloartenoid from Combretum molle leaves Phytochemistry 25 1759 1761
18. Van Wyk B, Van Wyk P (1997) Field guide to trees of Southern Africa. Struik, Cape Town
19. Watt JM, Breyer-Brandwijk MG (1962) The medicinal and poisonous plants of Southern and Eastern Africa, 2nd edn. E. & S. Livingstone, Edinburgh and London, pp 192-195