The weak evidence base for antibiotic prophylaxis in severe acute pancreatitis

Hepato-Gastroenterology

Volumn 55, Issue 88, 2008, Pages 2233-2237

  Wittau, Mathias ^a   Hohl, Kathrin ^b   Mayer, Jens ^a   Henne Bruns, Doris ^a   Isenmann, Rainer ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Antibiotic prophylaxis; Antibiotics; Pancreatitis; Prophylaxis; Severe acute pancreatitis

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; CEFTAZIDIME; CEFUROXIME; CIPROFLOXACIN; IMIPENEM; MEROPENEM; METRONIDAZOLE; OFLOXACIN; PEFLOXACIN; PLACEBO;

ACUTE HEMORRHAGIC PANCREATITIS; ANALYTICAL ERROR; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CHI SQUARE TEST; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE SEVERITY; DOSAGE SCHEDULE COMPARISON; EVIDENCE BASED MEDICINE; FISHER EXACT TEST; HUMAN; INCIDENCE; INFECTION CONTROL; LUNG INFECTION; METHODOLOGY; MORTALITY; OUTCOME ASSESSMENT; PANCREAS NECROSIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIBIOTIC PROPHYLAXIS; CEFUROXIME; CIPROFLOXACIN; DRUG COMBINATIONS; HUMANS; METRONIDAZOLE; PANCREATITIS; PANCREATITIS, ACUTE NECROTIZING; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 60849118397     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Banks PA: Epidemiology, natural history, and predictors of disease outcome in acute and chronic pancreatitis. Gastrointest. Endosc. 2002; 56(6 Suppl):S226-30.
2. DeFrances CJ, Hall MJ, Podgornik MN: 2008 National Hospital Discharge Survey. Advance data from vital and health statistics. No. 359. Hyattsville, Md.: National Center for Health Statistics, 2005.
3. McKay CJ, Imrie CW: The continuing challenge of early mortality in acute pancreatitis. Br J Surg 2004; 91:1243-4.
4. Isenmann R, Rünzi M, Kron M, et al.: Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis - a placebo-controlled, double-blind trial. Gastroenterology 2004; 126:997-1004.
5. Pederzoli P, Bassi C, Vesentini S, et al.: A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993; 176:480-483.
6. Sainio V, Kemppainen E, Puolakkainen P, et al.: Early antibiotic treatment in acute necrotizing pancreatitis. Lancet 1995; 346:663-667.
7. Glazer G, Mann D: United Kingdom guidelines for the management of acute pancreatitis. Gut 1998; 42(suppl 21:S1-S13.
8. Dervenis C, Johnson CD, Bassi C, et al.: Diagnosis, objective assessment of severity, and the management of acute pancreatitis. Int J Pancreatol 1999; 25:195-210.
9. Uhl W, Warshaw A, Imrie CW, et al.: IAP-guidelines for the surgical management of acute pancreatitis. Pancreatology 2002; 2:565-573.
10. Dellinger EP, Tellado JM, Soto NE, et al.: Early antibiotic treatment for severe acute necrotizing pancreatitis: randomized, double-blind, placebo-controlled study. Ann Surg 2007; 245:674-683.
11. Delcenserie R, Yzet T, Duccroix JP: Prophylactic antibiotics in treatment of severe acute alcoholic pancreatitis. Pancreas 1996; 13:198-201.
12. Schwarz M, Isenmann R, Meyer H, et al.: Antibiotika bei nekrotisierender Pankreatitis. Ergebnisse einer kontrollierten Studie. Dtsch Med Wochenschr 1997; 122:356-361.
13. Røkke O, Harbitz TB, Liljedal J, et al.: Early treatment of severe pancreatitis with imipenem: A prospective randomized clinical trial. Scand J Gastroenterol 2007; 42:771-776.
14. Bassi C, Falconi M,Talamini G, et al.: Controlled clinical trial of pefloxacin versus imipenem in severe acute pancreatitis. Gastroenterology 1998; 115:1513-17.
15. Nordback I, Sand J, Saaristo R, et al.: Early treatment with antibiotics reduces the need for surgery in acute necrotizing pancreatitis-a single-center randomized study. J Gastraintest Surg 2001; 5:113-8.
16. Maravi-Poma E, Gener J, Alvaraz-Loma F, et al.: Early antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimes with imipenemcilastatin. Intensive Care Med. 2003; 29:1974-1980.
17. Manes G, Rabitti PG, Menchise A, et al.: Prophylaxis with meropenem of septic complications in acute pancreatitis: a randomized, controlled trial versus imipenem. Pancreas 2003; 27:79-83.
18. Manes G, Uomo I, Menchise A; et al.: Timing of antibiotic prophylaxis in acute pancreatitis: a controlled randomized study with meropenem. Am J Gastroenterol 2006; 101:1348-1353.
19. Brown A: Prophylactic antibiotic use in severe acute pancreatitis: hemlock, help, or hype? Gastroenterology 2004; 126:1195-98.