Prophylactic Antibiotic Use in Severe Acute Pancreatitis: Hemlock, Help, or Hype?

Gastroenterology

Volumn 126, Issue 4, 2004, Pages 1195-1198

  Brown, Alphonso ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; METRONIDAZOLE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ACUTE PANCREATITIS; ANTIBIOTIC PROPHYLAXIS; BACTERICIDAL ACTIVITY; CLINICAL TRIAL; DISEASE SEVERITY; DRUG ADMINISTRATION; DRUG EFFICACY; DRUG PENETRATION; EDITORIAL; HUMAN; INFECTION; INFLAMMATION; INTESTINE; METHODOLOGY; MORTALITY; PANCREAS NECROSIS; PRIORITY JOURNAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 1842531118     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.02.027     Document Type: Editorial

References (27)

1. Go VLW, Everhart JE. Pancreatitis. In: Everhart JE, ed. Digestive diseases in the United States: epidemiology and impact. Washington, DC: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, 1994;693. NIH publication no. 94-1447.
2. Sandler RS, Everhart JE, Donowitz M, Adams E, Cronin K, Goodman C, Gemmen E, Shah S, Avdic A, Rubin R. The burden of selected digestive diseases in the United States. Gastroenterology 2002;122:1500-1511.
3. Thomson SR, Hendry WS, Mcfarlane GA, Davidson AI. Epidemiology and outcome of acute pancreatitis. Br J Surg 1987;74:398-401.
4. Bradley EL III. A clinically based classification system for acute pancreatitis. Ann Chir 1993;47:537-541.
5. Mann DV, Hershman MJ, Hittinger R, Glazer G. Multicentre audit of death from acute pancreatitis. Br J Surg 1994;81:890-893.
6. Formella LJ, Galloway SW, Kingsworth AN. Inflammatory mediators in acute pancreatitis. Br J Surg 1995;82:6-13.
7. Widdison AL, Karanjia ND. Pancreatic infection complicating acute pancreatitis. Br J Surg 1993;80:148-154.
8. Isenmann R, Runzi M, Kron M, Kahl S, Kraus D, Jung N, Maier L, Malfertheiner P, Goebell H, Berger HG, and the German Antibiotics in Severe Acute Pancreatitis (ASAP) Study Group. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology 2004;126:997-1004.
9. Craig RM, Dordal E, Myles L. The use of Ampicillin in acute pancreatitis [letter]. Ann Intern Med 1975;83:831-832.
10. Howes R, Zuidema GD, Cameron JL. Evaluation of prophylactic antibiotics in acute pancreatitis. J Surg Res 1975;18:197-200.
11. Finch WT, Sawyers JL, Schenker S. A prospective study to determine the efficacy of antibiotics in acute pancreatitis. Ann Surg 1976;183:667-671.
12. Buchler M, Malfertheiner P, Friess H, Isenmann R, Vanek E, Grimm H, Schlegel P, Friess T, Beger HG. Human pancreatic tissue concentration of bactericidal antibiotics. Gastroenterology 1992;103:1902-1908.
13. Bassi C, Pederzoli P, Vesentini C, Falconi M, Bonora A, Abbas H, Benini A, Bertazzoni EM. Behavior of antibiotics during human necrotizing pancreatitis. Antimicrob Agents Chemother 1994;38: 830-836.
14. Pederzoli P, Bassi C, Vesentini S, Campedelli A. A randomized multi-center clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993;176:480-483.
15. Delcenserie R, Yzet T, Ducroix JP. Prophylactic antibiotics in treatment of severe acute pancreatitis. Pancreas 1996;13:198-201.
16. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, Haapiainen R, Schroder T, Kivilaakso E. Early antibiotic treatment in acute necrotizing pancreatitis. Lancet 1995;346:663-667.
17. Schwarz M, Isenmann R, Meyer H, Beger HG. Antibiotic use in necrotizing pancreatitis. Results of a controlled study. Dtsch Med Wochenschr 1997;122:356-361.
18. Nordback I, Sand J, Saaristo R, Paajanen H. Early treatment with antibiotics reduces the need for surgery in acute necrotizing pancreatitis. A single-center randomized study. J Gastrointest Surg 2001;5:113-120.
19. Luiten EJ, Bruining HA. Antimicrobial prophylaxis in acute pancreatitis: selective decontamination versus antibiotics. Baillieres Best Pract Res Clin Gastroenterol 1999;13:317-330.
20. Takeda K, Matsuno S, Ogawa M, Watanabe S, Atomi Y. Continuous regional arterial infusion (CRAI) therapy reduces the mortality rate of acute necrotizing pancreatitis: results of a cooperative survey in Japan. J Hepatobiliary Pancreatic Surg 2001;8:216-220.
21. Bassi C, Falconi M, Talamini G, Uomo G, Papaccio G, Dervenis C, Salvia R, Minelli EB, Pederzoli P. Controlled trial of pefloxacin vs. imipenem in severe acute pancreatitis. Gastroenterology 1998; 115:1513-1517.
22. Sharma VK, Howden CW. Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis: a meta-analysis. Pancreas 2001;22:28-31.
23. Gotzinger P, Wamser P, Barlan M, Sautner T, Jakesz R, Fugger R. Candida infection of local necrosis in severe acute pancreatitis is associated with increased mortality. Shock 2000;14:320-323.
24. De Waele JJ, Vogelaers D, Blot S, Colardyn F. Fungal infections in patients with severe acute pancreatitis and the use of prophylactic therapy. Clin Infect Dis 2003;37:208-213.
25. Windsor AC, Kanwar S, Li AG, Barnes E, Guthrie JA, Spark JI, Welsh F, Guillou PJ, Reynolds JV. Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 1998;42:431-435.
26. Kalfarentzos F, Kehagias J, Mead N, Kokkinis K, et al. Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg 1997;84:1465-1669.
27. Brown A, Orav J, Banks PA. Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas 2000;20: 367-372.