Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans

RNA

Volumn 15, Issue 3, 2009, Pages 400-405

  Holtz, Janette ^a   Pasquinelli, Amy E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C; Elegans; Lin 14; Lin 4; MiRNA; Nutrient deprivation

Indexed keywords

LIN 14 PROTEIN; LIN 4 PROTEIN; MESSENGER RNA; MICRORNA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME REPRESSION; FEEDING; FOOD DEPRIVATION; GENE MUTATION; METABOLIC REGULATION; MUTANT; NONHUMAN; ORGANISM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REGULATORY MECHANISM; RNA DEGRADATION; RNA SPLICING; RNA TRANSLATION; WORM;

3' UNTRANSLATED REGIONS; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; MICRORNAS; NUCLEAR PROTEINS; RNA, MESSENGER;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 60849118376     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1258309     Document Type: Article

References (18)

1. Avruch, J., Hara, K., Lin, Y., Liu, M., Long, X., Ortiz-Vega, S., and Yonezawa, K. 2006. Insulin and amino acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25: 6361-6372.
2. Bagga, S., Bracht, J., Hunter, S., Massirer, K., Holtz, J., Eachus, R., and Pasquinelli, A.E. 2005. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122: 553-563.
3. Bhattacharyya, S.N., Habermacher, R., Martine, U., Closs, E.I., and Filipowicz, W. 2006. Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells. Cold Spring Harb. Symp. Quant. Biol. 71: 513-521.
4. Bracht, J., Hunter, S., Eachus, R., Weeks, P., and Pasquinelli, A.E. 2004. Trans-splicing and polyadenylation of let-7 microRNA primary transcripts. RNA 10: 1586-1594.
5. Chendrimada, T.P., Finn, K.J., Ji, X., Baillat, D., Gregory, R.I., Liebhaber, S.A., Pasquinelli, A.E., and Shiekhattar, R. 2007. MicroRNA silencing through RISC recruitment of eIF6. Nature 447: 823-828.
6. Feinbaum, R. and Ambros, V. 1999. The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans. Dev. Biol. 210: 87-95.
7. Filipowicz, W., Bhattacharyya, S.N., and Sonenberg, N. 2008. Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat. Rev. Genet. 9: 102-114.
8. Ha, I., Wightman, B., and Ruvkun, G. 1996. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes & Dev. 10: 3041-3050.
9. Hay, N. and Sonenberg, N. 2004. Upstream and downstream of mTOR. Genes & Dev. 18: 1926-1945.
10. Lee, R.C., Feinbaum, R.L., and Ambros, V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
11. Morita, K. and Han, M. 2006. Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans. EMBO J. 25: 5794-5804.
12. Moss, E.G., Lee, R.C., and Ambros, V. 1997. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88: 637-646.
13. Olsen, P.H. and Ambros, V. 1999. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216: 671-680.
14. Pasquinelli, A.E., McCoy, A., Jimenez, E., Salo, E., Ruvkun, G., Martindale, M.Q., and Baguna, J. 2003. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: A role in life history evolution? Evol. Dev. 5: 372-378.
15. Reinhart, B.J. and Ruvkun, G. 2001. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage- specific patterning. Genetics 157: 199-209.
16. Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R., and Ruvkun, G. 2000. The 21-nucleotide let-7 RNA regulates developmental timing in Caeno-rhabditis elegans. Nature 403: 901-906.
17. Seggerson, K., Tang, L., and Moss, E.G. 2002. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev. Biol. 243: 215-225.
18. Wightman, B., Ha, I., and Ruvkun, G. 1993. Post-transcriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862.