An immunohistochemical study of the role of matrix metalloproteinases and their tissue inhibitors in chronic mitral valvular disease (valvular endocardiosis) in dogs

Veterinary Journal

Volumn 180, Issue 1, 2009, Pages 88-94

  Aupperle, Heike ^a   Thielebein, Jens ^b   Kiefer, Birgit ^b   März, Imke ^a   Dinges, Gregor ^c   Schoon, H A ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c Tierärztliche Praxis Dr M Wiegand ^*  (Germany)

Author keywords

Chronic valvular disease; Dog; Immunohistochemistry; Matrix metalloproteinase; Mitral valve; Tissue inhibitor of metalloproteinase; Valvular endocardiosis

Indexed keywords

GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CELL ISOLATION; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; DOG DISEASE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; MITRAL VALVE DISEASE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; STROMA CELL;

ANIMALS; DOG DISEASES; DOGS; FEMALE; HEART VALVE DISEASES; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASES; MITRAL VALVE; SEVERITY OF ILLNESS INDEX; TISSUE INHIBITOR OF METALLOPROTEINASES;

CANIS FAMILIARIS;

EID: 60849116979     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.11.011     Document Type: Article

References (32)

1. Akhtar S., Meek K.M., and James V. Immunolocalisation of elastin, collagen type I and type III, fibronectin, and vitronectin in extracellular matrix components of normal and myxomatous mitral heart valve chordae tendineae. Cardiovascular Pathology 8 (1999) 203-211
2. Aupperle, H., Thielebein, J., Kiefer, B., März, I., Dinges, G., Schoon, H.-A., Schubert, A., MMPs and TIMPs in normal mitral valves and chronic degenerative valve disease (syn. endocardiosis) in dogs-mRNA analyses. Journal of Veterinary Cardiology, submitted for publication.
3. Barber J.E., Kasper F.K., Ratliff N.B., Cosgrove D.M., Griffin B.P., and Vesely I. Mechanical properties of myxomatous mitral valves. The Journal of Thoracic and Cardiovascular Surgery 122 (2001) 955-962
4. Barth P.J., Köster H., and Moosdorf R. CD34+ fibrocytes in normal mitral valves and myxomatous mitral valve degeneration. Pathology Research and Practice 201 (2005) 301-304
5. Black A., French A.T., Dukes-McEwan J., and Corcoran B.M. Ultrastructural morphologic evaluation of the phenotype of valvular interstitial cells in dogs with myxomatous degeneration of the mitral valve. American Journal of Veterinary Research 66 (2005) 1408-1414
6. Boudoulas H., Kolibash A.J., Baker P., King B.D., and Wooley C.F. Mitral valve prolapse and the mitral valve prolapse syndrome: a diagnostic classification and pathogenesis of symptoms. American Heart Journal 118 (1989) 797-818
7. Buchanan J.W. Chronic valvular disease (endocardiosis) in dogs. Advances of Veterinary Science in Comparative Medicine 21 (1977) 75-108
8. Cole W.G., Chan D., Hickey A.J., and Wilcken D.E.L. Collagen composition of normal and myxomatous human mitral valves. Biochemistry Journal 219 (1984) 451-460
9. Corcoran B.M., Black A., Dukes McEwan J., French A., Smith P., and Devine C. Identification of surface morphologic changes in the mitral valve leaflets and chordae tendineae of dogs with myxomatous degeneration. American Journal of Veterinary Research 65 (2004) 198-206
10. Day D.A., and Tuite M.F. Post-transcriptional gene regulatory mechanisms in eukaryotes: an overview. Journal of Endocrinology 157 (1998) 361-371
11. Dreger S.A., Taylor P.M., Allen S.P., and Yacoub M.H. Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves. Journal of Heart Valve Diseases 11 (2002) 875-880
12. Fondard O., Detaint D., Iung B., Choqueux C., Adle-Biassette H., Jarraya M., Hvass U., Couetil J.-P., Henin D., Michel J.-B., Vahanian A., and Jacob M.-P. Extracellular matrix remodelling in human aortic valvular disease: the role of matrix metalloproteinases and their tissue inhibitors. European Heart Journal 26 (2005) 1333-1341
13. Grüninger B., Schoon H.A., Schoon D., Menger S., and Klug E. Incidence and morphology of endometrial angiopathies in mares with relationship to age and parity. Journal of Comparative Pathology 119 (1998) 293-309
14. Häggström J., Pedersen H.D., and Kvart C. New insights into degenerative mitral valvular disease in dogs. Veterinary Clinics in Small Animal Practice 34 (2004) 1209-1226
15. Kogure K. Pathology of chronic mitral valvular disease in the dog. The Japanese Journal of Veterinary Science 42 (1980) 323-325
16. Koullias G.J., Korkoli D.P., Ravichandran P., Psyrri A., Hatzara I., and Elefteriades J.A. Tissue microarray detection of matrix metalloproteinases in diseased tricuspid and bicuspid aortic valves with or without pathology of the ascending aorta. European Journal of Cardio-Thoracic Surgery 26 (2004) 1098-1103
17. Li Y.Y., McTiernan C.F., and Feldman A.M. Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodelling. Cardiovascular Research 46 (2000) 214-224
18. Maxie M.G., and Robinson W.F. Myxomatous valvular degeneration ("endocardiosis") in dogs. In: Maxie M.G. (Ed). Jubb, Kennedy, and Palmer's The Pathology of Domestic Animals. fifth ed. vol. 3 (2007), Saunders Elsevier, Edinburgh 24-26
19. Mc Gregor E., and Dunn M.J. Proteomics of the heart: unravelling disease. Circulation Research 98 (2006) 309-321
20. Mow T., and Pedersen H.D. Increased endothelin-receptor density in myxomatous canine mitral valve leaflets. Journal of Cardiovascular Pathology 34 (1999) 254-260
21. Nasuti J.F., Zhang P.J., Feldman M.D., Pasha T., Kuhrana J.S., Gorman J.H., Gorman R.C., Narula J., and Narula N. Fibrillin and other matrix proteins in mitral valve prolapse syndrome. Annals of Thoracic Surgeons 77 (2004) 532-536
22. Olsen L.H., Mortensen K., Martinussen T., Larsson L.-I., Baandrup U., and Pedersen H.D. Increased NADPH-diaphorase activity in canine myxomatous mitral valve leaflets. Journal of Comparative Pathology 129 (2003) 120-130
23. Oyama M.A., and Chittur S.V. Genomic expression patterns of mitral valve tissue from dogs with degenerative mitral valve disease. American Journal of Veterinary Research 67 (2006) 1307-1318
24. Pedersen H.D., and Häggström J. Mitral valve prolapse in the dog: a model of mitral valve prolapse in man. Cardiovascular Research 47 (2000) 234-243
25. Peterson J.T., Li H., Dillon L., and Braynt J.W. Evolution of matrix metalloproteinase and tissue inhibitor expression during heart failure progression in the infarcted rat. Cardiovascular Research 46 (2000) 307-315
26. Rabkin E., Aikawa M., Stone J.R., Fukumoto Y., Libby P., and Schoen F.J. Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodelling in myxomatous heart valves. Circulation 104 (2001) 2525-2532
27. Robinson W.F., and Maxie M.G. Endocardiosis in dogs. In: Jubb K.V.F., Kennedy P.C., and Palmer N. (Eds). The Pathology of Domestic Animals. fourth ed. vol. 3 (1993), Academic press, San Diego, USA 23-24
28. Schneider P., Ernst E., and Trautwein G. Enzyme histocytochemical studies of atrioventricular heart valves in endocardiosis in the dog. Veterinary Pathology 10 (1973) 281-294
29. Soini Y., Satta J., Määttä M., and Autio-Harmainen H. Expression of MMP2, MMP9, MTI-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. Journal of Pathology 194 (2001) 225-231
30. Taylor P.M., Batten P., Brand N.J., Thomas P.S., and Yacoub M.H. The cardiac valve interstitial cell. International Journal of Biochemistry and Cell Biology 35 (2003) 113-118
31. Visse R., and Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases. Structure, function, and biochemistry. Circulation Research 92 (2003) 827-839
32. Whitney J.C. Cardiovascular pathology. Journal of Small Animal Practice 8 (1967) 459-465