Management of hiv positive pregnancies in ontario: Current status

Canadian Journal of Clinical Pharmacology

Volumn 16, Issue 1, 2009, Pages

  Gahir, Sarabjit ^a   Anger, Gregory J ^a   Ibrahim, Michael ^a   Read, Stanley ^b   Piquette Miller, Micheline ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Anti retroviral therapy; HIV; MTCT; Pregnancy

Indexed keywords

LAMIVUDINE; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CANADA; DELIVERY; FEMALE; GESTATIONAL AGE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; PRACTICE GUIDELINE; PREGNANCY COMPLICATION; PREGNANT WOMAN; PROPHYLAXIS; RETROSPECTIVE STUDY; TREATMENT DURATION; VERTICAL TRANSMISSION; VIRUS TRANSMISSION; CROSS-SECTIONAL STUDY; DISEASE TRANSMISSION; PREGNANCY; PREGNANCY OUTCOME; VIROLOGY;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LONGITUDINAL STUDIES; ONTARIO; PRACTICE GUIDELINES AS TOPIC; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES;

EID: 60849105364     PISSN: 1198581X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. P.H.A.O. Canada. HIV and AIDS in Canada: Surveillance Report to June 30, 2006. 2006:166.
2. Remis RS, Schiedel L, Fikre M, Liu J. Report on HIV/AIDS in Ontario 2005. O.M.o.H.a.L.-T. Care, Editor. 2007:1-192.
3. John GC, Nduati RW, Mbori-Ngacha DA, et al. Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections. J Infect Dis 2001;183(2):206-212.
4. Thea DM, Steketee RW, Pliner V, et al. The effect of maternal viral load on the risk of perinatal transmission of HIV-1. New York City Perinatal HIV Transmission Collaborative Study Group. Aids 1997;11(4):437-44.
5. Magder LS, Mofenson L, Paul ME, et al. Risk factors for in utero and intrapartum transmission of HIV. J Acquir Immune Defic Syndr 2005;38(1):87-95.
6. Burdge DR, Money DM, Forbes JC, et al. Canadian consensus guidelines for the care of HIV-positive pregnant women: putting recommendations into practice. CMAJ 2003;168(13):1683-8.
7. Brockleburst P. The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type I- a meta-analysis of 15 prospective cohort studies. J Pediatr 1999;135(5):649.
8. Group, P.H.G.W. Perinatal HIV Guidelines Working Group. Public health service task force recommendations for use of antiretroviral drugs in pregnant HIV-1- infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. In http://aidsinfo.nih.gov/ ContentFiles/Perinatal GL.pdf. 2006:1-65.
9. UNICEF. Children and AIDS: A stocktaking report. 2007. UNICEF.
10. Bialkowska A, Bialkowski K, Gerschenson M, et al. Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'- deoxythymidine (AZT). Carcinogenesis 2000;21(5):1059-62.
11. Calamandrei G, Venerosi A, Branchi I, Valanzano A, Alleva E. Prenatal exposure to anti-HIV drugs. Long-term neurobehavioral effects of lamivudine (3TC) in CD-1 mice. Neurotoxicol Teratol 2000;22(3):369-79.
12. Chitnis S, Mondal D, Agrawal KC. Zidovudine (AZT) treatment suppresses granulocyte-monocyte colony stimulating factor receptor type alpha (GM-CSFR alpha) gene expression in murine bone marrow cells. Life Sci 2002;71(8):967-78.
13. Olivero OA, Fernandez JJ, Antiochos BB, Wagner JL, St. Claire ME, Poirier MC. Transplacental genotoxicity of combined antiretroviral nucleoside analogue therapy in Erythrocebus patas monkeys. J Acquir Immune Defic Syndr2002;29(4):323-9.
14. Gerschenson M, Nguyen V, Ewings EL, et al. Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine. AIDS Res Hum Retroviruses 2004;20(1):91 -100.
15. Poirier MC, Olivero OA, Walker DM, Walker VE. Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs. Toxicol Appl Pharmacol 2004;199(2):151-61.
16. NTP Toxicology and Carcinogenesis Studies of Transplacental 3'-Azido-3'-Dioxythymidine (AZT) (CAS No. 30516-87-1) in Swiss (CD- 1(R)) Mice (in utero Studies). Natl Toxicol Program Tech Rep Ser 2006;(522): 1 -184.
17. Chan SS, Santos JH, Meyer JN, et al. Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environ Mol Mutagen 2007;48(3-4):190-200.
18. Divi RL, Leonard SL, Kuo MM, et al. Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor- induced mitochondrial toxicity. Environ Mol Mutagen 2007;48(3-4):201-9.
19. Martino M, Galli L, Tovo PA, et al for the Italian Register for HIV Infection in Children. Determinants of mother-to-infant human immunodeficiency virus 1 transmission before and after the introduction of zidovudine prophylaxis. Arch Pediatr Adolesc Med 2002;156(9):915-21.
20. Thorne C, Patel D, Fiore S, Peckham C, Newell M; for the European Collaborative Study. Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy. Clin Infect Dis 2005;40(3):458-65.
21. Read JS ; for The International Perinatal HIV Group. The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1- a meta-analysis of 15 prospective cohort studies. N Engl J Med 1999;340(13):977-87.
22. Kind C, Rudin C, Siegrist CA, et al. Prevention of vertical HIV transmission: additive protective effect of elective Cesarean section and zidovudine prophylaxis. Swiss Neonatal HIV Study Group. Aids 1998;12(2):205-10.
23. Shah I. Is elective caesarean section really essential for prevention of mother to child transmission of HIV in the era of antiretroviral therapy and abstinence of breast feeding? J Trop Pediatr 2006;52(3):163-5.
24. Zhang Z, Diwan BA, Anderson LM, et al. Skin tumorigenesis and Ki-ras and Ha-ras mutations in tumors from adult mice exposed in utero to 3'- azido-2',3'-dideoxythymidine. Mol Carcinog 1998;23(1):45-51.
25. Diwan BA, Riggs CW, Logsdon D, et al. Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice. Toxicol Appl Pharmacol 1999;161(1):82-99.
26. Walker DM, Malarkey DE, Seilkop SK, et al. Transplacental carcinogenicity of 3'-azido-3'- deoxythymidine in B6C3F1 mice and F344 rats. Environ Mol Mutagen 2007;48(3-4):283-98.