In Vitro Flexor Tendon Cell Response to TGF-β1: A Gene Expression Study

Journal of Hand Surgery

Volumn 34, Issue 3, 2009, Pages 495-503

  Klass, B R ^a   Rolfe, K J ^a   Grobbelaar, A O ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Adhesion; tendon; TGF 1

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL STIMULATION; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; FLEXOR TENDON; GENE EXPRESSION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TENDON SHEATH; UPREGULATION;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; DOWN-REGULATION; FIBRONECTINS; GENE EXPRESSION; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMERASE CHAIN REACTION; RABBITS; RNA; TENDONS; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; WOUND HEALING;

EID: 60849088860     PISSN: 03635023     EISSN: 15316564     Source Type: Journal    
DOI: 10.1016/j.jhsa.2008.10.032     Document Type: Article

References (51)

1. Pennisi E. Tending tender tendons. Science 295 (2002) 1011
2. Gelberman R.H., and Manske P.R. Factors influencing flexor tendon adhesions. Hand Clin 1 (1985) 35-42
3. Kulick M.I., Smith S., and Hadler K. Oral ibuprofen: evaluation of its effect on peritendinous adhesions and the breaking strength of a tenorrhaphy. J Hand Surg 11A (1986) 110-120
4. Hagberg L., and Gerdin B. Sodium hyaluronate as an adjunct in adhesion prevention after flexor tendon surgery in rabbits. J Hand Surg 17A (1992) 935-941
5. Khan U., Kakar S., Akali A., Bentley G., and McGrouther D.A. Modulation of the formation of adhesions during the healing injured tendon. J Bone Joint Surg 82B (2000) 1054-1058
6. Frykman E., Jacobsson S., and Widenfalk B. Fibrin sealant in prevention of flexor tendon adhesions: an experimental study in the rabbit. J Hand Surg 18A (1993) 68-75
7. Chang J., Thunder R., Most D., Longaker M.T., and Lineaweaver W.C. Studies in flexor tendon wound healing: neutralizing antibody to TGF-beta 1 increases postoperative range of motion. Plast Reconstr Surg 105 (2000) 148-155
8. Austin R.T., and Walker F. Flexor tendon healing and adhesion formation after Sterispon wrapping: a study in the rabbit. Injury 10 (1979) 211-216
9. Hanff G., and Hagberg L. Prevention of restrictive adhesions with expanded polytetrafluoroethylene diffusible membrane following flexor tendon repair: an experimental study in rabbits. J Hand Surg 23A (1998) 658-664
10. Golash A., Kay A., Warner J.G., Peck F., Watson J.S., and Lees V.C. Efficacy of ADCON-T/N after primary flexor repair in Zone II: a controlled clinical trial. J Hand Surg 28B (2003) 113-115
11. Coker R.K., and Laurent G.J. Pulmonary fibrosis: cytokines in the balance. Eur Respir J 11 (1998) 1218-1221
12. Okuda S., Languino L.R., Ruoslahti E., and Border W.A. Elevated expression of transforming growth factor beta and proteoglycan production in experimental glomerulonephritis: possible role in expansion of the mesangial extracellular matrix. J Clin Invest 86 (1990) 453-462
13. Bissell D.M., Roulot D., and George J. Transforming growth factor beta and the liver. Hepatology 34 (2001) 859-867
14. Chang J., Most D., Stelnicki E., Siebert J.W., Longaker M.T., Hui K., et al. Gene expression of transforming growth factor beta-1 in rabbit zone II flexor tendon wound healing: evidence for dual mechanisms of repair. Plast Reconstr Surg 100 (1997) 937-944
15. Klein M.B., Yalamanchi N., Pham H., Longaker M.T., and Chang J. Flexor tendon healing in vitro: effects of TGF-beta on tendon cell collagen production. J Hand Surg 27A (2002) 615-620
16. Border W.A., and Ruoslahti E. Transforming growth factor beta in disease: the dark side of tissue repair. J Clin Invest 90 (1992) 1-7
17. Gorvy D.A., Herrick S.E., Shah M., and Fergurson M.W. Experimental manipulation of transforming growth factor beta isoforms significantly affects adhesion formation in a murine surgical model. Am J Pathol 167 (2005) 1005-1019
18. Ngo M., Pham H., Longaker M.T., and Chang J. Differential expression of transforming growth factor beta receptors in a rabbit zone II flexor tendon wound healing model. Plast Reconstr Surg 108 (2001) 1260-1267
19. Chambers R.C., Leoni P., Kaminski N., Laurent G.J., and Heller R.A. Global expression profiling of fibroblast responses to transforming growth factor beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of a smooth muscle cell phenotypic switching. Am J Pathol 162 (2003) 533-546
20. Verrechia F., Chu M.L., and Mauviel A. Identification of novel TGF beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 276 (2001) 17058-17062
21. Balza E., Borsi L., Allemanni G., and Zardi L. Transforming growth factor beta regulates the levels of different fibronectin isoforms in normal cultured fibroblasts. FEBS Lett 228 (1988) 42-44
22. Williams I.F., McCullagh K.G., and Silver I.A. The distribution of types I and III collagen and fibronectin in the healing equine tendon. Connect Tissue Res 12 (1984) 211-227
23. Kutz S.M., Hordines J., McKeown-Longo P.J., and Higgins P.J. TGF-beta 1 induced PAI-1 gene expression requires MEK activity and cell to substrate adhesion. J Cell Sci 114 (2001) 3905-3914
24. Cheong Y.C., Laird S.M., Li T.C., Shelton J.B., Ledger W.L., and Cooke I.D. Peritoneal healing and adhesion formation/reformation. Hum Reprod Update 7 (2001) 556-566
25. Di Filippo C., Falsetto A., De Pascale V., Tufariello E., De Lucia D., Rossi F., et al. Plasma levels of t-PA and PAI-1 correlate with the formation of experimental post-surgical peritoneal adhesions. Mediators Inflamm 4 (2006) 1-4
26. Ivarsson M.L., Bergstrom M., Eriksson E., Risberg B., and Holmadhl L. Tissue markers as predictors of postoperative adhesions. Br J Surg 85 (1998) 1549-1554
27. Rolfe K.J., Irvine L.M., Grobbelaar A.O., and Linge C. Differential gene expression in response to transforming growth factor beta1 by fetal and postnatal dermal fibroblasts. Wound Repair Regen 15 (2007) 897-906
28. Fu S.C., Wong Y.P., Cheuk Y.C., Lee K.M., and Chan K.M. TGF- beta 1 reverses the effects of matrix anchorage on the gene expression of decorin and procollagen type I in tendon fibroblasts. Clin Orthop Relat Res 431 (2005) 226-232
29. -ΔΔCT method. Methods 25 (2001) 402-408
30. Tsubone T., Moran S.L., Subramaniam M., Amadio P.C., Spelsberg T.C., and An K.N. Effect of TGF-beta inducible early gene deficiency on flexor tendon healing. J Orthop Res 24 (2006) 569-575
31. Berglund M., Reno C., Hart D.A., and Wiig M. Patterns of mRNA expression for matrix molecules and growth factors in flexor tendon injury: differences in the regulation between tendon and tendon sheath. J Hand Surg 31A (2006) 1279-1287
32. Hsu C., and Chang J. Clinical implications of growth factors in flexor tendon wound healing. J Hand Surg 29A (2004) 551-563
33. Azuma C., Tohyama H., Nakamura H., Kanaya F., and Yasuda K. Antibody neutralization of TGF-beta enhances the deterioration of collagen fascicles in a tissue-cultured tendon matrix with ex vivo fibroblast infiltration. J Biomech 40 (2007) 2184-2190
34. Varga J., Rosenbloom J., and Jimenez S.A. Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 247 (1987) 597-604
35. Tiggelman A.M., Boers W., Linthorst C., Sala M., and Chamuleau R.A. Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1 beta, IL-4, TGF beta and IFN gamma. J Hepatol 23 (1995) 307-317
36. Chai Q., Krag S., Chai S., Ledet T., and Wogensen L. Localization and phenotypical characterization of collagen producing cells in TGF-beta 1-induced renal interstitial fibrosis. Histochem Cell Biol 119 (2003) 267-280
37. Benjamin M., Kumai T., Milz S., Boszczyk B.M., Boszczyk A.A., and Ralph J.R. The skeletal attachment of tendons-tendon "enthuses". Comp Biochem Physiol A Mol Integr Physiol 133 (2002) 931-945
38. Purslow P.P. The structure and functional significance of variations in the connective tissue within muscle. Comp Biochem Physiol A Mol Integr Phsyiol 133 (2002) 947-966
39. Jaibaji M. Advances in the biology of zone II flexor tendon healing and adhesion formation. Ann Plast Surg 45 (2000) 83-92
40. Gelberman R.H., Amiel D., and Harwood F. Genetic expression for type I procollagen in the early stages of flexor tendon healing. J Hand Surg 17A (1992) 551-558
41. Russell J.E., and Manske P.R. Collagen synthesis during primate flexor tendon repair in vitro. J Orthop Res 8 (1990) 13-20
42. Saika S., Yamanaka O., Kawashima Y., Ohkawa K., Ohnishi Y., Oshima A., et al. OPC 15161 suppresses the proliferation of Tenon's capsule fibroblasts and the production of type I collagen and fibronectin stimulated by TGF-beta1 in vitro. Curr Eye Res 17 (1998) 933-940
43. Fava R.A., and McClure D.B. Fibronectin-associated transforming growth factor. J Cell Physiol 131 (1987) 184-189
44. Wojciak B., and Crossan J.F. The accumulation of inflammatory cells in synovial sheath and epitenon during adhesion formation in healing rat tendon. Clin Exp Immunol 93 (1993) 108-114
45. Kehrl J.H., Wakefield L.M., Roberts A.B., Jakowlew S., Alvarez-Mon M., Derynck R., et al. Production of transforming growth factor-beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163 (1986) 1037-1050
46. Gelberman R.H., Steinberg D., Amiel D., and Akeson W. Fibroblast chemotaxis after tendon repair. J Hand Surg 16A (1991) 686-693
47. Zhao C., Cehn W., Yang L., Chen L., Stimpson S.A., and Diehl A.M. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun 350 (2006) 385-391
48. Orita H., Fukasawa M., Girgis W., and Di Zerega G.S. Inhibition of postsurgical adhesions in a standardized rabbit model: intraperitoneal treatment with tissue plasminogen activator. Int J Fertil 36 (1991) 172-177
49. Doody K.J., Dunn R.C., and Buttram Jr. V.C. Recombinant tissue plasminogen activator reduces adhesion formation in a rabbit uterine horn model. Fertil Steril 51 (1989) 509-512
50. Falk K., Bjorquist P., Stromqvist M., and Holmadahl L. Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1. Br J Surg 88 (2001) 286-289
51. Gelberman R.H., Vande Berg J.S., Manske P.R., and Akeson W.H. The early stages of flexor tendon healing: a morphologic study of the first fourteen days. J Hand Surg 10A (1985) 776-784