Physical exercise attenuates the cardiac autonomic deficit induced by nitric oxide synthesis blockade;O exercício físico atenua o déficit autonômico cardíaco induzido pelo bloqueio da síntese do óxido nítrico

Arquivos Brasileiros de Cardiologia

Volumn 92, Issue 1, 2009, Pages 29-36

  Rossi, Bruno Rafael Orsini ^a   Mazer, Denise ^a   Silveira, Larissa Christina Rossit ^a   Jacinto, Cynthia Pelegrino ^a   Di Sacco, Thaísa Helena Roseli ^a   Blanco, João Henrique Dutra ^a   Cesarino, Evandro José ^a   De Souza, Hugo Celso Dutra ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Jardim Recreio   (Brazil)

Author keywords

Exercise; Hypertension; Nitric oxide

Indexed keywords

METHYLATROPINE; N(G) NITROARGININE METHYL ESTER; PROPRANOLOL DERIVATIVE; ATROPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ENZYME INHIBITOR; NITRIC OXIDE SYNTHASE; PROPRANOLOL;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; ATTENUATION; BLOOD PRESSURE MONITORING; BRADYCARDIA; CARDIOVASCULAR EFFECT; COMPARATIVE STUDY; CONTROLLED STUDY; HEART RATE; HEART RATE VARIABILITY; HYPERTENSION; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; SYMPATHETIC TONE; TACHYCARDIA; TREADMILL EXERCISE; WISTAR RAT; ANALYSIS OF VARIANCE; ANIMAL; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC BETA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; ATROPINE DERIVATIVES; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HEART RATE; HYPERTENSION; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHYSICAL CONDITIONING, ANIMAL; PROPRANOLOL; RATS; RATS, WISTAR;

EID: 60749111235     PISSN: 0066782X     EISSN: 16784170     Source Type: Journal    
DOI: 10.1590/S0066-782X2009000100006     Document Type: Article

References (40)

1. Ribeiro MO, Antunes E, De Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis: a new model of arterial hypertension. Hypertension. 1992; 20: 298-303.
2. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991; 43: 109-42.
3. G-Melhyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ Res. 1992; 70: 607-11.
4. Togashi H, Sakuma I, Yoshioka M, Kobayashi T, Yasuda H, Kitabatake A, et al. A central nervous system action of nitric oxide in blood pressure regulation. J Pharmacol Exp Ther. 1992; 262: 343-7.
5. Souza HCD, Ballejo G, Salgado MCO, Silva VJD, Salgado HC. Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats. Am J Physiol - Heart Circ Physiol. 2001; 280: 844-50.
6. Panza JA. Endothelial dysfunction in essential hypertension. Clin Cardiol. 1997; 20 (11 Suppl 2): II-26-33.
7. Schlaich MP, Kaye DM, Lambert E, Sommerville M, Socratous F, Esler MD. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation. 2003; 108 (5): 560-5.
8. Arakawa K. Hypertension and exercise. Clin Exp Hypertens. 1993; 15 (6): 1171-9.
9. De Angelis K, Wichi RB, Jesus WR, Moreira ED, Morris M, Krieger EM, et al. Exercise training changes autonomic cardiovascular balance in mice. J Appl Physiol. 2004; 96 (6): 2174-8.
10. Niebauer J, Maxwell AJ, Lin PS, Wang D, Tsao PS, Cooke JP. NOS inhibition accelerates atherogenesis: reversal by exercise. Am J Physiol - Heart Circ Physiol. 2003; 285 (2): 535-40.
11. Medeiros A, Oliveira EM, Gianolla R, Casarini DE, Negrão CE, Brum PC. Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats. Braz J Med Biol Res. 2004; 37 (12): 1909-17.
12. Kuru O, Şentürk U, Demir N, Yeşilkaya A, Ergüler G, Erkiliç M. Effect of exercise on blood pressure in rats with chronic NOS inhibition. Eur J Appl Physiol. 2002; 87: 134-40.
13. Carter JB, Banister EW, Blaber AP. Effect of endurance exercise on autonomic control of heart rate. Sports Med. 2003; 33: 33-46.
14. Goldsmith RL, Bloomfield DM, Rosenwinkel ET. Exercise and autonomic function. Coron Artery Dis. 2000; 11: 129-35.
15. Maiorana A, O'Driscoll G, Taylor R, Green D. Exercise and the nitric oxide vasodilator system. Sports Med. 2003; 33: 1013-35.
16. Malliani A, Pagani M, Lombardi F, Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation. 1991; 84: 482-92.
17. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of The European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996; 93: 1043-65.
18. Husain K. Interaction of exercise training and chronic NOS inhibition on blood pressure, heart rate, NO and antioxidants in plasma of rats. Pathophysiology. 2003; 10: 47-56.
19. Sears CE, Choate JK, Paterson DJ. NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation. J Appl Physiol. 1999; 86: 510-6.
20. Elvan A, Rubart M, Zipes DP. NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open-chest dogs. Am J Physiol. 1997; 272: 263-71.
21. Mohan RM, Heaton DA, Danson EJF, Krishnan SPR, Cai S, Channon KM, et al. Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function. Circ Res. 2002; 91: 1089-91.
22. Danson EJ, Paterson DJ. Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice. J Physiol. 2003; 546: 225-32.
23. Stein R, Medeiros CM, Rosito GA, Zimerman LI, Ribeiro JP. Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes. J Am Coll Cardiol. 2002; 39 (6): 1033-8.
24. Arai Y, Saul JP, Albrecht P, Hartley LH, Lilly LS, Cohen RJ, et al. Modulation of cardiac autonomic activity during and immediately after exercise. Am J Physiol - Heart Circ Physiol. 1989; 256: H132-H141.
25. Van de Borne P, Montano N, Pagani M, Oren R, Somers VK. Absence of low-frequency variability of sympathetic nerve activity in severe heart failure. Circulation. 1997; 95: 1449-54.
26. Ma S, Abboud FM, Felder RB. Effects of L-arginine-derived nitric oxide synthesis on neuronal activity in nucleus tractus solitarius. Am J Physiol. 1995; 268: R487-R491.
27. Tseng CJ, Liu HY, Lin HC, Ger LP, Tung CS, Yen MH. Cardiovascular effects of nitric oxide in the brain stem nuclei of rats. Hypertension. 1996; 27 (1): 36-42.
28. Kagiyama S, Tsuchihashi T, Abe I, Fujishima M. Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats. Brain Res. 1997; 757 (1): 155-8.
29. Shapoval LN, Sagach VF, Pobegailo LS. Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat. Neurosci Lett. 1991; 132 (1): 47-50.
30. Dias AC, Vitela M, Colombari E, Mifflin SW. Nitric oxide modulation of glutamatergic, baroreflex, and cardiopulmonary transmission in the nucleus of the solitary tract. Am J Physiol - Heart Circ Physiol. 2005; 288 (1): H256-62.
31. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994; 74 (2): 349-53.
32. Zheng H, Li Y, Cornish KG, Zucker IH, Patel KP. Exercise training improves endogenous nitric oxide mechanisms within the paraventricular nucleus in rats with heart failure. Am J Physiol - Heart Circ Physiol. 2005; 288: H2332-H2341.
33. Kramer JM, Plowey ED, Beatty JA, Little HR, Waldrop TG. Hypothalamus, hypertension, and exercise. Brain Res Bull. 2000; 53 (1): 77-85.
34. Zucker IH, Patel KP, Schultz HD, Li YF, Wang W, Pliquett RU. Exercise training and sympathetic regulation in experimental heart failure. Exerc Sport Sci Rev. 2004; 32 (3): 107-11.
35. Higa-Taniguchi KT, Silva FC, Silva HM, Michelini LC, Stern JE. Exercise training-induced remodeling of paraventricular nucleus (nor)adrenergic innervation in normotensive and hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2007; 292 (4): R1717-27.
36. DiCarlo SE, Zheng H, Collins HL, Rodenbaugh DW, Patel KP. Daily exercise normalizes the number of diaphorase (NOS) positive neurons in the hypothalamus of hypertensive rats. Brain Res. 2002; 955 (1-2): 153-60.
37. Martinka P, Fielitz J, Patzak A, Regitz-Zagrosek V, Persson PB, Stauss HM. Mechanisms of blood pressure variability-induced cardiac hypertrophy and dysfunction in mice with impaired baroreflex. Am J Physiol Regul Integr Comp Physiol. 2005; 288 (3): R767-76.
38. Souza HCD, Penteado DMD, Martin-Pinge MC, Neto OB, Teixeira VPA, Blanco JHD, et al. Nitric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic training. Arq Bras Cardiol. 2007; 89 (2): 88-93.
39. Persson K, Johansson K, Alm P, Larsson B, Andersson KE. Morphological and functional evidence against a sensory and sympathetic origin of nitric oxide synthase-containing nerves in the rat lower urinary tract. Neuroscience. 1997; 77 (1): 271-81.
40. Nafz B, Wagner CD, Persson PB. Endogenous nitric oxide buffers blood pressure variability between 0.2 and 0.6 Hz in the conscious rat. Am J Physiol. 1997; 272: H632-7.