Inhibition of P13K/PKB signal pathway improves chemotherapeutic effect on gastric carcinoma cell lines

Chinese Pharmacological Bulletin

Volumn 24, Issue 12, 2008, Pages 1666-1670

  Xie, Xia ^a   Gao, Qing ^a   Wang, Yan Li ^a   Tian, Chun ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; LY294002; SGC7901 cells; SGC7901 VCR cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CARCINOMA; WESTERN BLOTTING;

EID: 60749108719     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ji B S, Yue S M, He L. Reversal of resistance to doxorubicin by CJZ3, a lomerizine amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia(K562/DOX) cells [J]. Chin Pharmacol Bull, 2007, 23(11): 1431-6.
2. Wang L, Liu S K, Zhou Y L, et al. Reversal effect of cirrobufacine on adriamycin resistancehuman breast cancer cells[J]. Chin Pharmacol Bull, 2007, 23(5): 677-80.
3. Han Z, Hong L, Han Y, et al. Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax[J]. J Exp Clin Cancer Res, 2007, 26(2): 261-8.
4. Misra S, Ghatak S, Toole B P. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase,and ErbB2[J]. J Biol Chem, 2005, 280 (21): 20310-5.
5. Xia S, Yu S Y. Inhibition of P13K/Akt signal pathway improves chemotherapeutic effect[J]. Tumor, 2006, 26(4): 311-3.
6. Michl P, Downward J. Mechanisms of disease: P13K/AKT signaling in gastrointestinal cancers [J]. J Gastroenterol, 2005, 43 (10): 1133-9.
7. Nam S Y, Lee H S, Jung G A, et al. Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis [J]. APMIS, 2003, 111(12): 1105-13.
8. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle [J]. Cell, 2002, 109 Suppl:S81-96.
9. Zhao L Z, Yin W, Su X W, et al. IGF-1 protection against cerebellar granule neurons apoptosis induced by diphenylhydantoin through a P13K/ Akt dependent pathway [J]. Chin Pharmacol Bull, 2005, 21(1): 53-7.
10. Zhang D, Fan D. Multidrug resistance in gastric cancer: recent research advances and ongoing therapeutic challenges [J]. Exp Rev Anticancer Ther, 2007, 7(10): 1369-78.
11. Xu H B, He L, Liu G Q, et al. The reversal of P-glycoprotein-mediated MDR by GP associated with chemotherapeutic drugs [J]. Chin Pharmacol Bull, 2007, 23(9): 1207-12.
12. Ambudkar, Suresh V, Kimchi-Sarfaty C, et al. P-glycoprotein: from genomics to mechanism[J]. Oncogene, 2003, 22(47): 7468-85.
13. Yang J M, Vassil A, Hait W N. Involvement of phosphatidylinositol-3-kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells [J]. Biochem Pharmacol, 2002, 63(5): 959-66.
14. Barancik M, Bohacova, V, Sedlak J, et al. LY294 002, a specific inhibitor of P13K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance [J]. Eur J Pharm Sci, 2006, 29(5): 426-34.
15. Dan H C, Sun M, Kaneko S, et al. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein(XIAP) [J]. J Biol Chem, 2004, 279(7): 5405-12.