Influence of ALDH2 polymorphism on ethanol kinetics and pulmonary effects in male and female rats exposed to ethanol vapors

Inhalation Toxicology

Volumn 21, Issue 3, 2009, Pages 193-199

  Scarino, A ^a   Tardif, R ^a   Charbonneau, M ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; LUNG LAVAGE; LUNG TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; TOXICOKINETICS; VAPOR;

ALDEHYDE DEHYDROGENASE; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ETHANOL; FEMALE; INHALATION EXPOSURE; LUNG; MALE; MITOCHONDRIAL PROTEINS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; POLYMORPHISM, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; TIME FACTORS; TRACHEA; VOLATILIZATION;

RATTUS;

EID: 60749106677     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370802372815     Document Type: Article

References (21)

1. Carvalho, E. M., Brito, G. A. C., Pessoa, B. B. G. P., Ribeiro, R. A., and Capaz, F. R. 2005. Long-term ethanol intoxication reduces inflammatory responses in rats. Braz. J. Med. Biol. Res. 38:81-89.
2. Chu, I., Poon, R., Valli, V., Yagminas, A., Bowers, W. J., Seegal, R., and Vincent, R. 2005. Effects of an ethanol-gasoline mixture: Results of a 4-week inhalation study in rats. J. Appl. Toxicol. 25:193-199.
3. Del Zoppo, G. 2003. Aldehyde dehydrogenase (ALDH2) polymorphism and the pulmonary effects associated with exposure to ethanol vapors in the rat. Master's Thesis, Institut National de Recherche Scientifique (INRS) - Institut Armand-Frappier 531 boul. des Prairies Laval (Qúebec), Canada.
4. Health Canada. 2005. Gasoline with ethanol: A green alternative. Available at http://oee.nrcan.gc.ca/Publications/transportation/ ethanolawareness.cfm?Text=N&PrintView=N (accessed December 2005).
5. Lieber, C. S. 2000. Ethnic and gender differences in ethanol metabolism. Alcohol. Clin. Exp. Res. 24:417-418.
6. Luo, H. R., and Zhang, Y.P. 2004. Aldehyde dehydrogenase (ALDH2) polymorphism and drinking behavior. Yi Chuan. 26:263-266.
7. Marietta, C. A., Jerrels, T. R., Meagher, R. C., Karanian, J.W., Weoght, F. F., and Eckardt, M. J. 1988. Effects of long-term inhalation on the immune and hematopoietic systems of the rat. Alcohol. Clin. Exp. Res. 12:211-214.
8. Manautou, J. E., and Carlson, G. P. 1992. Comparison of rat pulmonary and hepatic cytosolic alcohol dehydrogenase activities. J. Toxicol. Environ. Health. 35:7-18.
9. McElroy, M. C., Postle, A. D., and Kelly, F. J. 1992. Catalase, superoxidase dismutase and glutathione peroxidase activities of lung and liver during human development. Biochim. Biophys. Acta. 1117:153-158.
10. Oyama, T., Isse, T., Kagawa, N., Kinaga, T., Kim, Y. D., Morita, M., Sugio, K., Weiner, H., Yasumoto, K., and Kawamoto, T. 2005. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. Front. Biosci. 10:951-960.
11. Parkinson, A. 2001. Biotransformation of xenobiotics. In Casarett and Doull's toxicology. The basic science of poisons, ed. C.D. Klaassen, 6th ed., pp. 152-156. New York: McGraw-Hill.
12. Pastino, G. M., Asgharian, B., Roberts, K., Medinsky, M. A., and Bond, J. 1997. A comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats, and humans. Toxicol. Appl. Pharmacol. 145:147-157.
13. Rowlands, J. C., He, L., and Badger, T. M. 2003. Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells. Xenobiotica 33:389-397.
14. Seitz, H. K., Egerer, G., Simanowski, U. A., Waldherr, R., Eckey, R., Agarwal, D. P., Goedde, H. W., and von Wartburg, J.P. 1993. Human gastric alcohol dehydrogenase activity: Effect of age, sex, and alcoholism. Gut 34:1433-1437.
15. Szabo, G. 1999. Consequences of alcohol consumption on host defence. Alcohol alcohol. 34: 830-841.
16. Takao, A., Shimoda, T., Kohno, S., Asai, S., and Harda, S. 1998. Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype. J. Allergy Clin .Immunol. 101: 576-580.
17. Tardif, R., and Charbonneau, M. 2001. Caractérisation de la toxicocinétique de l'acétaldéhyde et de l'éthanol après inhalation de vapeurs d'éthanol chez le rat. TSRI Project #318. Final Report, Toxic Substances Research Initiative, Government of Canada, Ottawa, Canada.
18. U.S. EPA. 1994. Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. Office of Research and Development, Washington, DC. EPA/600/8-90/066F. Available on-line at http://www.epa.gov/cgi-bin/claritgw?op-Display&document=clserv:ORD: 0327;&rank=4&template=epa
19. Yamauchi, M., Maezawa, Y., Satoh, S., Mizuhara, Y., and Toda, G. 1996. Genetic polymorphism of the rat aldehyde dehydrogenase 2 and the severity of experimental alcohol-induced lover damage. Int. Hepatol. Comm. 5:143-149.
20. Yang, M., Coles, B. F., Delongchamp, R., Lang, N. P., and Kadlubar, F. F. 2002. Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphism on their expressions in Caucasian lung tissue. Lung Cancer 38:15-21.
21. Zerilli, A., Lucas, D., Amet, Y., Beauge, F., Volant, A., Floch, H. H., Berthou, F., and Menez, J. F. 1995. Cytochrome P-450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation. Alcohol Alcohol. 30:357-365.