Genetic polymorphism of the rat aldehyde dehydrogenase 2 and the severity of experimental alcohol-induced liver damage

International Hepatology Communications

Volumn 5, Issue 2, 1996, Pages 143-149

  Yamauchi, M ^a   Maezawa, Y ^a   Satoh, S ^a   Mizuhara, Y ^a   Toda, G ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

alcoholic liver disease; aldehyde dehydrogenase; genetic polymorphism; hepatic fibrosis

Indexed keywords

ALDEHYDE DEHYDROGENASE;

ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENETIC POLYMORPHISM; HETEROZYGOSITY; LIVER FIBROSIS; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT;

EID: 0029999914     PISSN: 09284346     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-4346(96)00294-0     Document Type: Article

References (10)

1. N Enomoto S Takase N Takada A Takada Alcoholic liver disease in heterozygotes of mutant and normal aldehyde dehydrogenase-2 genes Hepatology 13 1991 1071 1075
2. T-K Li L Lumeng WJ McBride JM Murphy Rodent lines selected for factors affetig alohol consuption Alcohol and Alcohol 1 1987 91 97 (Suppl)
3. LG Carr RJ Mellencamp DW Crabb L Lumeng T-K Li A polymorphism in the rat mitochondrial ALDH2 gene is associated with alcohol drinking behavior H Weiner B Wermuth DW Crabb Enzymology and Biology of Carbonyl Metabolism 1990 Plenum Press New York 61 65
4. J Farres K-L Guan H Weinr Primary structures of rat and bovine liver mitochondrial adehyde dehydrogenases deduced frm cDNA sequnces Eur J Biocem 180 1989 67 74
5. LG Carr RJ Mellencamp DW Crabb H Weiner L Lumeng T-L Li Polymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA Alcohol Clin Exp Res 15 1991 753 756
6. M Yamauchi J Hirakawa K Kimura Sex difference in the development of alcoholic liver disease in the rat liver Acta Hepatol Jap 41 1989 643 648
7. AL Leon M Rojkind A siple micromethod for collagen and total protein determinatio in formalin-fixed paraffi-embedded sections J Histochem Cytochem 1985 737 743
8. LM Kunkel KD Smith SH Boyer Analysis of human Y chromosome-specific reiterated DNA in chromosome variants Proc Natl Acad Sci USA 74 1977 1245 1249
9. M Yamauchi Y Maezawa Y Mizuhara Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: A multivariate analysis Hepatology 22 1995 1136 1142
10. A Yoshida I-Y Husng M Ikawa Molecular abnormality of an inactive aldehyde dehydrogenase gene results in loss of enzyme activity Proc Natl Acad Sci USA 81 1984 258 261