Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats

Inhalation Toxicology

Volumn 21, Issue 3, 2009, Pages 182-192

  Antonini, James M ^a   Roberts, Jenny R ^a   Stone, Sam ^a   Chen, Bean T ^a   Schwegler Berry, Diane ^a   Frazer, David G ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; MANGANESE; STEEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; HOST RESISTANCE; LISTERIA MONOCYTOGENES; LUNG INJURY; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT INFLAMMATION; WELDING FUME;

AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; INHALATION EXPOSURE; IRON; LACTATE DEHYDROGENASES; LISTERIA INFECTIONS; LUNG INJURY; MALE; MANGANESE; NEUTROPHILS; PARTICULATE MATTER; PNEUMONIA; RATS; RATS, SPRAGUE-DAWLEY; ROBOTICS; SERUM ALBUMIN; STEEL; TIME FACTORS; WELDING;

ANIMALIA; BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES; RATTUS;

EID: 60749105024     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370802360661     Document Type: Article

References (27)

1. Antonini, J. M., Krishna Murthy, G. G., Rogers, R. A., Albert, R., Ulrich, G. D., and Brain, J. D. 1996. Pneumotoxicity and pulmonary clearance of different welding fumes after intratracheal instillation in the rat. Toxicol. Appl. Pharmacol. 140:188-199.
2. Antonini, J. M., Clarke, R. W., Krishna Murthy, G. G., Sreekanthan, P., Jenkins, N., Eagar, T. W., and Brain, J. D. 1998. Freshly generated stainless steel welding fume induced greater lung inflammation in rats as compared to aged fumes. Toxicol. Lett. 98:77-86.
3. Antonini, J. M., Roberts, J. R., and Clarke, R. W. 2001. Strain-related differences of nonspecific respiratory defense mechanisms in rats using a pulmonary infectivity model. Inhal. Toxicol. 13:85-102.
4. Antonini, J. M. 2003. Health effects of welding. Crit. Rev. Toxicol. 33:61-203.
5. Antonini, J. M., Taylor, M. D., Millecchia, L., Bebout, A. R., and Roberts, J. R. 2004. Suppression in lung defenses after bacterial infection in rats pretreated with different welding fumes. Toxicol. Appl. Pharmacol. 200:206-218.
6. Antonini, J. M., Afshari, A. A., Stone, S., Chen, B., Scwegler-Berry, D., Fletcher, W. G., Goldsmith, W. T., Vandestouwe, K. H., McKinney, W., Castranova, V., and Frazer, D. G. 2006. Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals. J. Occup. Environ. Hyg. 3:194-203.
7. Antonini, J. M., Stone, S., Roberts, J. R., Chen, B., Schwegler-Berry, D., Afshari, A., and Frazer, D. G. 2007. Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense reponses in rats. Toxicol. Appl. Pharmacol. 223:234-245.
8. Antonini, J. M., and Roberts, J. R. 2007. Chromium in stainless steel welding fume suppresses lung defense responses against bacterial infection in rats. J. Immunotoxicol. 4:117-127.
9. Avashia, S. B., Riggins, W. S., Lindley, C., Hoffmaster, A., Drumgoole, R., Nekomoto, T., Jackson, P. J., Hill, K. K., Williams, K., Lehman, L., Libal, M. C., Wilkins, P. P., Alexander, J., Tvaryanas, A., and Betz, T. 2007. Fatal pneumonia among metaklworkers due to inhalation exposure to Bacillus cereus containing Bacillus anthracis toxic genes. Clin. Infect. Dis. 44:414-416.
10. Beckett, W. S. 1996. Welding. In Occupational and Environmental Respiratory Disease, eds. P. Harber, M. B. Schenker, and J. R. Balmes, pp. 704-717. St. Louis, MO: Mosby-Year Book, Inc.
11. Brain, J. D., Knudson, D. W., Sorokin, S. P., and Davis, M. A. 1976. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ. Res. 11:13-33.
12. Coggon, D., Inskip, H., Winter, P., and Pannett, B. 1994. Lobar pneumonia: An occupational disease in welders. Lancet 344:41-43.
13. Doig, A. T., and Challen, P. J. R. 1964. Respiratory hazards in welding. Ann. Occup. Hyg. 7:223-231.
14. Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., and Aderem, A. 2004. Lipocalin-2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432:917-921.
15. Hoffmaster, A. R., Hill, K. K., Gee, J. E., Marston, C. K., De, B. K., Popovic, T., Sue, D., Wilkins, P. P., Avashia, S. B., Drumgoole, R., Helma, C. H., Ticknor, L. O., Okinaka, R. T., and Jackson, P. J. 2006. Characterization of Bacillus cereus isolates associated with fatal pneumonias: Strains are closely related to Bacillus anthrachis and harbor B. anthracis virulence genes. J. Clin. Microbiol. 44:3352-3360.
16. Howden, D. G., Desmeules, M. J. A., Saracci, R., Sprince, N. L., and Herber, P. I. 1988. Respiratory hazards of welding: Occupational exposure characterization. Am. Rev. Respir. Dis. 138:1047-1048.
17. Jenkins, N. T., and Eagar, T .W. 2005. Chemical analysis of welding fume particles. Welding J. 84:87s-93s.
18. Jenkins, N. T., Pierce, W. M.-G., and Eagar, T. W. 2005. Particle size distribution of gas metal and flux cored arc welding fumes. Welding J. 84:156s-163s.
19. Kleinfeld, M., Messite, J., Kooyman, O., and Spiro, J. 1969. Welders' siderosis: A clinical roentgenographic and physiological study. Arch. Environ. Health 19:70-73.
20. Morgan, W. K. C. 1989. On welding, wheezing, and whimsy. Am. Ind. Hyg. Assoc. J. 50:59-69.
21. NIOSH. 1994. Elements (ICP): Method 7300. In NIOSH Manual of Analytical Methods, 4th ed., Issue 2, US Department of Health and Human Services, Publication No. 98-119. Washington, DC: NIOSH.
22. Palmer, K. T., Poole, J., Ayres, J. G., Mann, J., Burge, P. S., and Coggon, D. 2003. Exposure to metal fume and infectious disease. Am. J. Epidemiol. 157:227-233.
23. Sferlazza, S. J., and Beckett, W. S. 1991. The respiratory health of welders. Am. Rev. Respir. Dis. 143:1134-1148.
24. Solano-Lopez, C., Zeidler-Erdely, P. C., Hubbs, A. F., Reynolds, S. H., Roberts, J. R., Taylor, M. D., Young S.-H., Castranova, V., and Antonini, J. M. 2006. Welding fume exposure and associated inflammatory and hyerplastic changes in the lungs of tumor susceptible A/J mice. Toxicol. Pathol. 34:364-372.
25. Taylor, M. D., Roberts, J. R., Leonard, S. S., Shi, X., and Antonini, J. M. 2003. Effects of welding fumes of differing composition and solubility on free radical production and acute lung injury and inflammation in rats. Toxicol. Sci. 75:181-191.
26. Wergeland, E., and Iversen, B. G. 2001. Deaths from pneumonia after welding. Scand. J. Work Environ. Health 27:353.
27. Zimmer, A. T., and Biswas, P. 2001. Characterization of the aerosols resulting from arc welding processes. J. Aerosol Sci. 32:993-1008.