Pharmacokinetics of curcumin solid dispersion in mice

Chinese Pharmacological Bulletin

Volumn 24, Issue 11, 2008, Pages 1525-1527

  Huang, Xiu Wang ^a   Xu, Jian Hua ^a   Wu, Guo Hua ^a   Wen, Cai Xia ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Curcumin; HPLC; Pharmacokinetics; Solid dispersion

Indexed keywords

CURCUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; SINGLE DRUG DOSE;

EID: 60749101598     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Wang Y, Hu J B, Chen Y, et al. Curcumin causes histone acetylation enhancement in Raji HL60 and K562 cell lines [J]. Chin Pharmacol Bull,2006, 22(2):164-7.
2. Sun J, Li Y. Effects of curcumin on expression of HIF-1α in human hepatocellular carcinoma BEL-7402 cells[J]. Chin Pharmacol Bull,2006, 22(11):1379-83.
3. Xu C X, Wang C, Zhu B Y, et al. Curcumin attenuates IL-1β-induced endothelial lipase expression via blocking NF-κB pathway [J]. Chin Pharmacol Bull,2008,24(1):75-9.
4. Hold G M, Plummer J L, Ryan A J. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-haptadiene-3,5-dione) in the rat[J]. Xenobiotica,1978,8(12):761-8.
5. Ireson C, Orr S, Jones D J. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production[J]. Cancer Res,2001, 61(3):1058-64.
6. Ricky A S, Heather R M, Kirsti A H, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer[J]. Clin Cancer Res,2001,7(7):1894-900.
7. Xu J H, Zhao R, Wu G T. Antitumor activity of curcumin in vitro and vivo[J]. Pharmacol Clin Chin Mater Med,1998,14(3):15-7.
8. Xu H L, Sun Y, Shan J Z, et al. Study on pharmacokinetics of the curcumin liposomes in rat [J]. J Hubei Coll Tradit Chin Med, 2007,9(1):42-3.