Procalcitonin: A reliable marker for the diagnosis and monitoring of the course of bacterial infection;Prokalcitonin: Spolehlivý ukazatel pro diagnostiku a monitorování průběhu bakteriální infekce

Klinicka Mikrobiologie a Infekcni Lekarstvi

Volumn 14, Issue 6, 2008, Pages 201-208

  Holub, Michal ^a   Rozsypal, H ^a   Chalupa, P ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Bacterial infection; Diagnosis; Procalcitonin; Sepsis

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; PROCALCITONIN;

ADULT RESPIRATORY DISTRESS SYNDROME; BACTERIAL INFECTION; BACTERIAL MENINGITIS; CALCITONIN BLOOD LEVEL; COMMUNITY ACQUIRED PNEUMONIA; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE MARKER; DRUG MONITORING; FEBRILE NEUTROPENIA; HUMAN; LEUKOCYTE COUNT; MENINGOCOCCOSIS; MYCOSIS; NEUTROPHIL COUNT; PREDICTION; PYELONEPHRITIS; REVIEW; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK;

EID: 60749099184     PISSN: 1211264X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. Zima T. Laboratorní diagnostika, 2. vyd. Praha: Galén-Karolinum; 2007.
2. Záhorec, R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001; 102(1):5-14.
3. Wyllie DH, Bowler IC, Peto TE. Relation between lymphopenia and bacteraemia in UK adults with medical emergencies. J Clin Pathol. 2004;57(9):950-5.
4. Papaevangelou V, Papassotiriou I, Sakou I. et al. Evaluation of a quick test for C-reactive protein in a pediatric emergency department. Scand J Clin Lab Invest. 2006;66(8):717-21.
5. Adams NG. Diagnostic use of C-reactive protein in bacteraemic emergency department patients. Emerg Med Australas. 2005; 17(4):371-5.
6. Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993;341(8844):515-8.
7. Mallet E, Lanse X, Devaux AM, et al. Hypercalcitoninaemia fulminant meningococcaemia in children. Lancet. 1983;321(8319):294.
8. Ghillani PP, Motté P, Troalen F, et al. Identification and measurement of calcitonin precursors in serum of patients with malignant diseases. Cancer Res. 1989; 49(23):6845-51.
9. Nijsten MW, Olinga P, The TH, et al. Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Crit Care Med. 2000;28(2):458-61.
10. Carrol ED, Thomson AP, Hart CA. Procalcitonin as a marker of sepsis. Int J Antimicrob Agents. 2002;20(1):1-9.
11. Linscheid P, Seboek D, Schaer DJ, et al. Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Crit Care Med. 2004;32(8): 1715-21.
12. Novák I. Prokalcitonin, časná diagnostika sepse a léčba antibiotiky. Anest. intenziv. Med. 2006; 17(3):135-6.
13. Wagner KE, Martinez JM, Vath SD, et al. Early immunoneutralization of calcitonin precursors attenuates the adverse physiologic response to sepsis in pigs. Crit Care Med. 2002;30(10):2313-21.
14. Christofilopoulou S, Charvalos E, Petrikkos G. Could procalcitonin be a predictive biological marker in systemic fungal infections? Study of 14 cases. Eur J Intern Med. 2002;13(8):493-495.
15. Petrikkos GL, Christofilopoulou SA, Tentolouris NK, et al. Value of measuring serum procalcitonin, C-reactive protein, and mannan antigens to distinguish fungal from bacterial infections. Eur J Clin Microbial Infect Dis. 2005;24(4):272-5.
16. Chiwakata CB, Manegold C, Bönicke L, et al. Procalcitonin as a parameter of disease severity and risk of mortality in patients with Plasmodium falciparum malaria. J Infect Dis. 2001;183(7):1161-4.
17. de Werra I, Jaccard C, Corradin SB, et al. Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med. 1997;25(4):607-13.
18. Hatherill M, Tibby SM, Sykes K, et al. Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count. Arch Dis Child. 1999;81(5):417-21.
19. Nobre V, Harbarth S, Graf JD, et al. Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med. 2008;177(5):498-505.
20. Cheval C, Timsit JF, Garrouste-Orgeas M, et al. Procalcitonin (PCT) is useful in predicting the bacterial origin of an acute circulatory failure in critically ill patients. Intensive Care Med. 2000;26(Suppl 2):S153-8.
21. Shehabi Y, Seppelt I. Pro/Con debate: is procalcitonin useful for guiding antibiotic decision making in critically ill patients? Crit Care. 2008;12(3):211.
22. Charles PE, Ladoire S, Aho S, et al. Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either Gram negative or Gram positive bacteria. BMC Infect Dis. 2008;8:38.
23. Giamarellos-Bourboulis EJ, Grecka P, Poulakou G, et al. Assessment of procalcitonin as a diagnostic marker of underlying infection in patients with fibrile neutropenia. Clin Infect Dis. 2001;32(12): 1718-28.
24. Fleischhack G, Kambeck I, Cipic D, et al. Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II. Br J Haematol. 2000; 111(4):1093-102.
25. Giamarellou H, Giamarellos-Bourboulis EJ, Repoussis P, et al. Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study. Clin Microbiol Infect. 2004;10(7):628-33.
26. Ruokonen E, Nousiainen T, Pulkki K, Takala J. Procalcitonin concentrations in patients with neutropenic fever. Eur J Clin Microbiol Infect Dis. 1999;18(4):283-5.
27. Giamarellou H, Giamarellos-Bourboulis EJ, Repoussis P, et al. Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study. Clin Microbiol Infect. 2004; 10(7):628-33.
28. Lepe Jiménez JA, Vázquez Florido A, Ramos de Mora M, et al. Utility of procalcitonin, C-reactive protein and leukocyte count in the detection of meningococcal disease during an epidemic cluster. An Pediatr (Barc). 2005;62(4):328-32.
29. Mills GD, Lala HM, Oehley MR, et al. Elevated procalcitonin as a diagnostic marker in meningococcal disease. Eur J Clin Microbiol Infect Dis. 2006;25(8):501-9.
30. Schwarz S, Bertram M, Schwab S, et al. Serum procalcitonin levels in bacterial and abacterial meningitis. Crit Care Med. 2000;28(6):1828-32.
31. Beović B, Kreft S, Osredkar J, et al. Serum procalcitonin levels in patients with mild community-acquired pneumonia. Clin Microbiol Infect. 2005;11(12):1050-1.
32. Tseng JS, Chan MC, Hsu JY, et al. Procalcitonin is a valuable prognostic marker in ARDS caused by community-acquired pneumonia. Respirology 2008;13(4): 505-9.
33. Brunkhorst FM, Eberhard OK, Brunkborst R. Discrimination of infectious and noninfectious causes of early acute respiratory distress syndrome by procalcitonin. Crit Care Med. 1999;27(10):2172-6.
34. Rea-Neto A, Youssef NC, Tuche F, et al. Diagnosis of ventilator-associated pneumonia: a systematic review of the literature. Crit Care. 2008;12(2):R56.
35. Benador N, Siegrist CA, Gendrel D, et al. Procalcitonin is a marker of severity of renal lesions in pyelonephritis. Pediatrics. 1998; 102(6):1422-5.
36. Lemiale V, Renaud B, Moutereau S, et al. A single procalcitonin level does not predict adverse outcomes of women with pyelonephritis. Eur Urol. 2007;51(5): 1394-401.
37. Dörge H, Schöndube FA, Dörge P, et al. Procalcitonin is a valuable prognostic marker in cardiac surgery but not specific for infection. Thorac Cardiovasc Surg. 2003;51(6):322-6.
38. Clec'h C, Fosse JP, Karoubi P, et al. Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock. Crit Care Med. 2006;34(1): 102-7.
39. Nylén ES, Al Arifi A, Becker KL, et al. Effect of classic heatstroke on serum procalcitonin. Crit Care Med. 1997;25(8):1362-5.
40. Maruna P. Prokalcitonin. 1. vyd. Praha; Triton; 2003.
41. Dornbusch HJ, Strenger V, Sovinz P, et al. Non-infectious causes of elevated procalcitonin and C-reactive protein serum levels in pediatric patients with hematologic and oncologic disorders. Support Care Cancer. 2008;16(9):1035-40.
42. Gkonos PJ, Born W, Jones BN, et al. Biosynthesis of calcitonin gene-related peptide and calcitonin by a human medullary thyroid carcinoma cell line. J Biol Chem. 1986;261(31):14386-91.
43. Cate CC, Pettengill OS, Sorenson GD. Biosynthesis of procalcitonin in small cell carcinoma of the lung. Cancer Res. 1986;46(2):812-8.
44. Steinbach G, Bölke E, Grünert A, et al. Procalcitonin in patients with acute and chronic renal insufficiency. Wien Klin Wochenschr. 2004,116(24):849-53. Erratum in: Wien Klin Wochenschr. 2005;117(4):172.
45. Mändi Y, Farkas G, Takács T, et al. Diagnostic relevance of procalcitonin, IL-6, and sICAM-1 in the prediction of infected necrosis in acute pancreatitis. Int J Pancreatol. 2000;28(1):41-9.
46. Moosig F, Csernok E, Reinhold-Keller E, et al. Elevated procalcitonin levels in active Wegener's granulomatosis. J Rheumatol. 1998;25(8):1531-3.
47. Schwenger V, Sis J, Breitbart A, et al. CRP levels in autoimmune disease can be specified by measurement of procalcitonin. Infection. 1998;26(5):274-6.
48. Christ-Crain M, Jaccard-Stolz D, Bingisser R, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet 2004; 363(9409):600-7.
49. Christ-Crain M, Stolz D, Bingisser R, et al. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med. 2006;174(1):84-93.
50. Müller B, Schuetz P, Trampuz A. Circulating biomarkers as surrogates for blood-stream infections. Int J Antimicrob Agents. 2007;30(Suppl 1):S16-23.
51. Valenta J, Jabor A, Brodská H, et al. Analýza specifity a senzitivity prokalcitoninu ve srovnání s dalšími markery zánětu u kriticky nemocných. Anest. intenziv. Med. 2006;17(3):164-70.
52. Eberhard OK, Langefeld I, Kuse ER, et al. Procalcitonin in the early phase after renal transplantation-will it add to diagnostic accuracy? Clin Transplant. 1998;12(3):206-11.
53. Hammer C, Fraunberger P, Meiser B, et al. Procalcitonin: a new marker for diagnosis of acute rejection and nonviral infection of heart and lung transplant patients. Transplant Proc. 2001;33(3):2204-6.