PPP1R9B (Neurabin 2): Involvement and dynamics in the NK immunological synapse

European Journal of Immunology

Volumn 39, Issue 2, 2009, Pages 552-560

  Meng, Xiaobo ^a,b   Kanwar, Namita ^a,b   Du, Qiujiang ^a,b   Goping, Ing S ^c   Bleackley, R Chris ^c   Wilkins, John A ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

CD18; CD28; NK; PPP1R9B; Synapse

Indexed keywords

ACTIN; CD18 ANTIGEN; CD28 ANTIGEN; F ACTIN; SPINOPHILIN; ACTIN BINDING PROTEIN; NERVE PROTEIN; NEURABIN;

ARTICLE; CELL LINE; CELL STIMULATION; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOSKELETON; DYNAMICS; EXPRESSION VECTOR; HUMAN; HUMAN CELL; IMAGING; IMMUNE SYSTEM; IMMUNOBLOTTING; KINETICS; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA INTERFERENCE; STAINING; SYNAPSE; VIRUS TITRATION; CYTOLOGY; IMMUNOLOGICAL SYNAPSE; IMMUNOLOGY; METABOLISM; TUMOR CELL LINE;

ACTINS; ANTIGENS, CD18; ANTIGENS, CD28; CELL LINE, TUMOR; CYTOSKELETON; HUMANS; IMMUNOLOGICAL SYNAPSES; KILLER CELLS, NATURAL; MICROFILAMENT PROTEINS; NERVE TISSUE PROTEINS;

EID: 60749093351     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838474     Document Type: Article

References (30)

1. Billadeau, D. D., Nolz, J. C. and Gomez, T. S., Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 2007. 7: 131-143.
2. Cemerski, S. and Shaw, A., Immune synapses in T-cell activation. Curr. Opin. Immunol. 2006. 18: 298-304.
3. Lettau, M., Schmidt, H., Kabelitz, D. and Janssen, O., Secretory lysosomes and their cargo in T and NK cells. Immunol. Lett. 2007. 108: 10-19.
4. Montoya, M. C., Sancho, D., Vicente-Manzanares, M. and Sanchez-Madrid F., Cell adhesion and polanty during immune interactions. Immunol. Rev. 2002. 186: 68-82.
5. Campbell, K. S. and Colonna, M., Human natural killer cell receptors and signal transduction. Int. Rev. Immunol. 2001. 20: 330-370.
6. Chen, X., Trivedi, P. P., Ge, B. X., Krzewski, K. and Strominger, J. L., Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity. Proc. Natl. Acad. Sci. USA 2007. 104: 6329-6334.
7. Chiesa, S., Tomasello, E., Vivier, E. and Vely, F., Coordination of activating and inhibitory signals in natural killer cells. Mol. Immunol. 2005. 42: 477-484.
8. MacFarlane, A. W. and Campbell, K.S., Signal transduction in natural killer cells, in: Vivier, E. and Colonna, M. (Eds), Immunobiology Of Natural Killer Cell Receptors (Current Topics in Microbiology and immunology), Springer, Berlin Heidelberg 2006, pp. 23-57.
9. Orange, J. S., Harris, K. E., Andzelm, M. M., Valter, M. M., Geha, R. S. and Strominger, J. L., The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc. Natl. Acad. Sci. USA 2003. 1OO: 14151-14156.
10. Billadeau, D. D. and Burkhardt, J. K., Regulation of cytoskeletal dynamics at the immune synapse: New stars join the, actin troupe. Traffic 2006. 7: 1451-1460.
11. Menager, M. M., Menasche, G., Romap, M., Knapnougel, P., Ho, C. H., Garfa, M., Raposo, G. et al., Secretory cytotoxic granule maturation and exocytosis require the effector protein hMuncl3-4. Nat. Immunol. 2007. 8: 257-267.
12. Stinchcombe, J. C., Majorovits, E., Bossi, G., Fuller, S. and Griffiths, G.M. Centrosome polarization delivers secretory granules to the immunological synapse. Nature 2006. 443: 462-465.
13. Chen, X., Allan, D. S. J., Krzewski, K., Ge, B. X., Kopcow, H. and Strominger, J. L., CD28-stimulated ERK2 phospho'rylation is required for polarization of the microtubule organizing center and granules in YTS NK cells. Proc. Natl. Acad. Sci. USA 2006. 103: 10346-10351.
14. Graham, D. B., Cella, M., Giurisato, E., Fujikawa, K., Miletic, A. V., Kloeppel, T., Brim, K. et al., Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J. Immunol. 2006. 177: 2349-2355.
15. Standeven, L. J., Carlin, L. M., Borszcz, P., Davis, D. M. and Burshtyn, D. N., The actin cytoskeleton controls the efficiency of killer Ig-like receptor accumulation at inhibitory NK cell immune synapses. J. Immunol. 2004. 173: 5617-5625.
16. Meng, X. B. and Wilkins, J. A., Compositional characterization of the cytoskeleton of NK-like cells. J. Proteome Res. 2005. 4: 2081-2087.
17. Meng, X. B., Krokhin, 0., Cheng, K. D., Ens, W. and Wilkins, J. A., Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion. J. Proteome Res. 2007. 6: 744-750.
18. Satoh, A., Nakanishi, H., Obaishi, H., Wada, M., Takahashi, K., Satoh, K., Hirao, K. et al., Neurabin-II/spinophilin - an actin filament-binding protein with one PDZ domain localized at cadherin-based cell-cell adhesion sites. J. Biol. Chem. 1998. 273: 3470-3475.
19. Sarrouilhe, D., di Tommaso, A., Metaye, T. and Ladeveze, V., Spinophilin: From partners to functions. Biochimie 2006. 88: 1099-1113.
20. Nakanishi, H., Obaishi, H., Satoh, A., Wada, M., Mandai, K., Satoh, K., Nishioka, H. et al., Neurabin: A novel neural tissue-specific actin filament-binding protein involved in neurite formation. J. Cell Biol. 1997. 139: 951-961.
21. Terry-Lorenzo, R. T., Roadcap, D. W., Otsuka, T., Blanpied, T. A., Zamoranq, P. L., Garner, C. C., Shenolikar, S, and Ehlers, M. D., Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. Mol. Biol. Cell 2005. 16: 2349-2362.
22. Colbran, R. J., Carmody, L. C., Bauman, P. A., Wadzinski, B. E. and Bass, M. A., Analysis of specific interactions of native protein phosphatase 1 isoforms with targeting subunits. Methods Enzymol. 2003. 366: 156-175.
23. Yamada, S. and Nelson, W. J., Synapses: Sites of cell recognition, adhesion, and functional specification. Annu. Rev. Biochem. 2007. 76: 267-294.
24. Chen, X., Trivedi, P. P., Ge. X., Krzewski, K. and Strominger, J. L., Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity. Proc. Natl. Acad. Sci. USA 2007. 104: 6329-6334.
25. Feng, J., Yan, Z., Ferreira, A., Tomizawa, K., Liauw, J. A., Zhuo, M., Allen, P. B. et al., Spinophilin regulates the formation and function of dendritic spines. Proc. Natl. Acad. Sci. USA 2000. 97: 9287-9292.
26. Bielas, S. L., Serneo, F. F., Chechlacz, M., Deerinck, T. J., Perkins, G. A., Allen, P. B., Ellisman, M. H. and Gleeson, J. G., Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell 2007. 129: 579-591.
27. Allen, P. B., Ouimet, C. C. and Greengard, P., Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Proc. Natl. Acad. Sci. USA 1997. 94: 9956-9961.
28. Giannoni, E., Chiarugi, P., Cozzi, G., Magnelli, L., Taddei, M. L., Fiaschi, T., Buricchi, F. et al., Lymphocyte function-associated antigen-1-mediated T cell adhesion is impaired by low molecular weight phosphotyrosine phosphatase-dependent inhibition of FAK activity. J. Biol. Chem. 2003. 278: 36763-36776.
29. Riteau, B., Barber, D. F. and Long, E. 0., Vav1 phosphorylation is induced by beta 2 integrin engagement an natural killer cells upstream of actin cytoskeleton and lipid raft reorganization. J. Exp. Med. 2003. 198: 469-474.
30. Allen, P. B., Zachariou, V., Svenningsson, P., Lepore, A. C., Centonze, D., Costa, C., Rossi, S. et al., Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neuroscience 2006. 140: 897-911.