Stereotactic Radiosurgery for Early Stage Non-Small Cell Lung Cancer: Rationale, Patient Selection, Results, and Complications

Seminars in Thoracic and Cardiovascular Surgery

Volumn 20, Issue 4, 2008, Pages 290-297

  Christie, Neil A ^a   Pennathur, Arjun ^a   Burton, Steven A ^b   Luketich, James D ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

early stage lung cancer; high risk patients; lung cancer; medically inoperable patients; stereotactic radiosurgery

Indexed keywords

GEMCITABINE;

ARTICLE; CANCER MORTALITY; CANCER STAGING; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DYSPNEA; EXTERNAL BEAM RADIOTHERAPY; FATIGUE; HUMAN; INOPERABLE CANCER; LUNG LOBECTOMY; LUNG NON SMALL CELL CANCER; OUTCOME ASSESSMENT; PATIENT SELECTION; POSTOPERATIVE COMPLICATION; RADIATION DOSE FRACTIONATION; STEREOTACTIC RADIOSURGERY; SURGICAL TECHNOLOGY; TREATMENT PLANNING; UNITED STATES;

CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; LUNG NEOPLASMS; NEOPLASM STAGING; PATIENT SELECTION; POSTOPERATIVE COMPLICATIONS; RADIOSURGERY;

EID: 60749092764     PISSN: 10430679     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semtcvs.2008.12.001     Document Type: Article

References (55)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2008. CA Cancer J Clin 58 (2008) 71-96
2. Ginsberg R.J., Rubinstein L.V., and Lung Cancer Study Group. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Ann Thorac Surg 60 (1995) 615-622 discussion 622-623
3. Okada M., Nishio W., Sakamoto T., et al. Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection. J Thorac Cardiovasc Surg 129 (2005) 87-93
4. Yoshikawa K., Tsubota N., Kodama K., et al. Prospective study of extended segmentectomy for small lung tumors: the final report. Ann Thorac Surg 73 (2002) 1055-1058 discussion 1058-1059
5. Choong C.K., Meyers B.F., Battafarano R.J., et al. Lung cancer resection combined with lung volume reduction in patients with severe emphysema. J Thorac Cardiovasc Surg 127 (2004) 1323-1331
6. Korst R.J., Ginsberg R.J., Ailawadi M., et al. Lobectomy improves ventilatory function in selected patients with severe COPD. Ann Thorac Surg 66 (1998) 898-902
7. Chen M., Hayman J.A., Ten Haken R.K., et al. Long-term results of high-dose conformal radiotherapy for patients with medically inoperable T1-3N0 non-small-cell lung cancer: is low incidence of regional failure due to incidental nodal irradiation?. Int J Radiat Oncol Biol Phys 64 (2006) 120-126
8. Wigren T., Kellokumpu-Lehtinen P., and Ojala A. Radical radiotherapy of inoperable non-small cell lung cancer. Irradiation techniques and tumor characteristics in relation to local control and survival. Acta Oncologica (Stockholm, Sweden) 31 (1992) 555-561
9. Graham M.V., Pajak T.E., Herskovic A.M., et al. Phase I/II study of treatment of locally advanced (T3/T4) non-oat cell lung cancer with concomitant boost radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12): long-term results. Int J Radiat Oncol Biol Phys 31 (1995) 819-825
10. Dosoretz D.E., Galmarini D., Rubenstein J.H., et al. Local control in medically inoperable lung cancer: an analysis of its importance in outcome and factors determining the probability of tumor eradication. Int J Radiat Oncol Biol Phys 27 (1993) 507-516
11. Jeremic B., Classen J., and Bamberg M. Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 54 (2002) 119-130
12. McGarry R.C., Papiez L., Williams M., et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys 63 (2005) 1010-1015
13. Zimmermann F.B., Geinitz H., Schill S., et al. Stereotactic hypofractionated radiation therapy for stage I non-small cell lung cancer. Lung Cancer 48 (2005) 107-114
14. Le Q.T., Loo B.W., Ho A., et al. Results of a phase I dose-escalation study using single-fraction stereotactic radiotherapy for lung tumors. J Thorac Oncol 1 (2006) 802-809
15. Timmerman R., McGarry R., Yiannoutsos C., et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol 24 (2006) 4833-4839
16. NETTR Group. Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med 345 (2001) 1075-1083
17. Firat S., Bousamra M., Gore E., et al. Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 52 (2002) 1047-1057
18. Port J.L., Kent M., Korst R.J., et al. Surgical resection for lung cancer in the octogenarian. Chest 126 (2004) 733-738
19. Mery C.M., Pappas A.N., Bueno R., et al. Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database. Chest 128 (2005) 237-245
20. Onaitis M.W., Petersen R.P., Balderson S.S., et al. Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients. Ann Surg 244 (2006) 420-425
21. McKenna Jr. R.J., Houck W., and Fuller C.B. Video-assisted thoracic surgery lobectomy: experience with 1100 cases. Ann Thorac Surg 81 (2006) 421-425 discussion 425-426
22. Fishman A., Martinez F., Naunheim K., et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 348 (2003) 2059-2073
23. McGarry R.C., Song G., des Rosiers P., et al. Observation-only management of early stage, medically inoperable lung cancer: poor outcome. Chest 121 (2002) 1155-1158
24. Kaskowitz L., Graham M.V., Emami B., et al. Radiation therapy alone for stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys 27 (1993) 517-523
25. Qiao X., Tullgren O., Lax I., et al. The role of radiotherapy in treatment of stage I non-small cell lung cancer. Lung Cancer 41 (2003) 1-11
26. Bradley J.D., Ieumwananonthachai N., Purdy J.A., et al. Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 52 (2002) 49-57
27. Alberts W.M. The future and lung cancer: room for optimism?. Cancer Control 7 (2000) 13-14
28. Baumann M., Appold S., Petersen C., et al. Dose and fractionation concepts in the primary radiotherapy of non-small cell lung cancer. Lung Cancer 33 suppl 1 (2001) S35-S45
29. Abratt R.P., and Morgan G.W. Lung toxicity following chest irradiation in patients with lung cancer. Lung Cancer 35 (2002) 103-109
30. Byhardt R.W., Martin L., Pajak T.F., et al. The influence of field size and other treatment factors on pulmonary toxicity following hyperfractionated irradiation for inoperable non-small cell lung cancer (NSCLC)-analysis of a Radiation Therapy Oncology Group (RTOG) protocol. Int J Radiat Oncol Biol Phys 27 (1993) 537-544
31. Bradley J., Graham M.V., Winter K., et al. Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 61 (2005) 318-328
32. Kong F.M., Hayman J.A., Griffith K.A., et al. Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 65 (2006) 1075-1086
33. Lagerwaard F.J., Senan S., van Meerbeeck J.P., et al. Has 3-D conformal radiotherapy (3D CRT) improved the local tumour control for stage I non-small cell lung cancer?. Radiother Oncol 63 (2002) 151-157
34. Giraud P., De Rycke Y., Dubray B., et al. Conformal radiotherapy (CRT) planning for lung cancer: analysis of intrathoracic organ motion during extreme phases of breathing. Int J Radiat Oncol Biol Phys 51 (2001) 1081-1092
35. Shimizu S., Shirato H., Ogura S., et al. Detection of lung tumor movement in real-time tumor-tracking radiotherapy. Int J Radiat Oncol Biol Phys 51 (2001) 304-310
36. Engelsman M., Sharp G.C., Bortfeld T., et al. How much margin reduction is possible through gating or breath hold?. Phys Med Biol 50 (2005) 477-490
37. Mah D., Hanley J., Rosenzweig K.E., et al. Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. Int J Radiat Oncol Biol Phys 48 (2000) 1175-1185
38. Keall P.J., Kini V.R., Vedam S.S., et al. Potential radiotherapy improvements with respiratory gating. Australas Phys Eng Sci Med 25 (2002) 1-6
39. Willoughby T.R., Forbes A.R., Buchholz D., et al. Evaluation of an infrared camera and X-ray system using implanted fiducials in patients with lung tumors for gated radiation therapy. Int J Radiat Oncol Biol Phys 66 (2006) 568-575
40. Harada T., Shirato H., Ogura S., et al. Real-time tumor-tracking radiation therapy for lung carcinoma by the aid of insertion of a gold marker using bronchofiberscopy. Cancer 95 (2002) 1720-1727
41. Cheung P.C., Yeung L.T., Basrur V., et al. Accelerated hypofractionation for early-stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 54 (2002) 1014-1023
42. Blomgren H., Lax I., Göranson H., et al. Radiosurgery for tumors in the body: clinical experience using a new method. J Radiosurg 1 (1998) 63-74
43. Reichner C.A., Collins B.T., Gagnon G.J., et al. The placement of gold fiducials for cyberknife stereotactic radiosurgery using a modified transbronchial needle aspiration technique. J Bronchol 12 (2005) 193-195
44. Krol A.D., Aussems P., Noordijk E.M., et al. Local irradiation alone for peripheral stage I lung cancer: could we omit the elective regional nodal irradiation?. Int J Radiat Oncol Biol Phys 34 (1996) 297-302
45. Williams T.E., Thomas Jr. C.R., and Turrisi III A.T. Counterpoint: better radiation treatment of non-small cell lung cancer using new techniques without elective nodal irradiation. Semin Radiat Oncol 10 (2000) 315-323
46. Robertson J.M., Ten Haken R.K., Hazuka M.B., et al. Dose escalation for non-small cell lung cancer using conformal radiation therapy. Int J Radiat Oncol Biol Phys 37 (1997) 1079-1085
47. Slotman B.J., Antonisse I.E., and Njo K.H. Limited field irradiation in early stage (T1-2N0) non-small cell lung cancer. Radiother Oncol 41 (1996) 41-44
48. Whyte R.I., Crownover R., Murphy M.J., et al. Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial. Ann Thorac Surg 75 (2003) 1097-1101
49. Pennathur A., Luketich J.D., Burton S., et al. Stereotactic radiosurgery for the treatment of lung neoplasm: initial experience. Ann Thorac Surg 83 (2007) 1820-1824 discussion 1824-1825
50. Pennathur A, Luketich JD, Heron DE, et al: Stereotactic radiosurgery for the treatment of stage I non-small cell lung cancer in high-risk patients. J Thorac Cardiovasc Surg (in press)
51. Timmerman R., Papiez L., McGarry R., et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest 124 (2003) 1946-1955
52. Onishi H., Araki T., Shirato H., et al. Stereotactic hypofractionated high-dose irradiation for stage I non-small cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multi-institutional study. Cancer 101 (2004) 1623-1631
53. Berger B., Wood R., and Fiedler J. Initial report of cyberknife radiosurgery for non-surgical lung tumors. Presented at Cyberknife Society Users' Meeting, Carlsbad, California, January 25-28 (2006)
54. Collins B.T., Erickson K., Reichner C.A., et al. Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors. Radiat Oncol 2 (2007) 39
55. Bellairs E., Fink A., and Palmer M. Extracranial radiosurgery for lung tumors. Presented at Cyberknife Society Users' Meeting. Carlsbad, California, January 25-28 (2006)