Prevalence of genes for aminoglycoside-modifying enzymes in Staphylococcus epidermidis isolates from orthopedic postsurgical and implant-related infections

Journal of Biomedical Materials Research - Part A

Volumn 88, Issue 3, 2009, Pages 654-663

  Campoccia, Davide ^a   Montanaro, Lucio ^a,b   Pirini, Valter ^a   Ravaioli, Stefano ^a   Arciola, Carla Renata ^a,b  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Aminoglycoside modifying enzymes; Antibiotic resistance genes; Orthopedi: Implant; Ribotyping; Staphylococcus epidermidis

Indexed keywords

AMINOGLYCOSIDE-MODIFYING ENZYMES; ANTIBIOTIC RESISTANCE GENES; ORTHOPEDI: IMPLANT; RIBOTYPING; STAPHYLOCOCCUS EPIDERMIDIS;

AIRCRAFT LANDING SYSTEMS; CATALYSTS; ENZYMES; GENES;

ANTIBIOTICS;

AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; BIOMATERIAL; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BONE INFECTION; CLONE; ENZYME MODIFICATION; GENE IDENTIFICATION; IMPLANT; NONHUMAN; ORTHOPEDIC SURGERY; POSTOPERATIVE INFECTION; RIBOTYPING; SEROPREVALENCE; STAPHYLOCOCCUS EPIDERMIDIS;

AMINOGLYCOSIDES; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ORTHOPEDICS; PHENOTYPE; PROSTHESIS IMPLANTATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOGRAMIN B;

EID: 60549106051     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31754     Document Type: Article

References (34)

1. Arciola CR, An YH, Campoccia D, Donati ME, Montanaro L. Etiology of implant orthopedic infections: A survey on 1027 clinical isolates. Int J Artif Organs 2005;28:1091-1100.
2. Mohanty SS, Kay PR. Infection in total joint replacements. Why we screen MRSA when MRSE is the problem? lone Joint Surg Br 2004;86:266-268.
3. Arciola CR, Campoccia D, Gamberini S, Donati ME, Pirini V, Visai L, Speziale P, Montanaro L. Antibiotic resistance in exopolysaccharide-forming Staphylococcus epidermidis clinical isolates from orthopaedic implant infections. Biomaterials 2005; 26:6530-6535.
4. Presterl E, Lassnigg A, Parschalk B, Yassin F, Adametz H, Graninger W. Clinical behavior of implant infections due to Staphylococcus epidermidis. Int J Artif Organs 2005;28:1110-1118.
5. Campoccia D, Montanaro L, Arciola CR. The significance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials 2006;27:2331-2339.
6. Lyon BR, Skurray R. Antimicrobial resistance of Staphylococcus aureus: Genetic basis. Microbiol Rev 1987;51:88-134.
7. Schmitz F-J, Jones ME. Antibiotics for treatment of infections caused by MRSA and elimination of MRSA carriage. What are the choices? Int J Antimicrob Agents 1997;9:1-19.
8. Mader JT, Cantrell JS, Calhoun J. Oral ciprofloxacin compared with standard parenteral antibiotic therapy for chronic osteomyelitis in adults. J Bone Joint Surg Am 1990;72:104-110.
9. Bint AT Gentamicin-resistant Staphylococcus aureus. J Antimicrob Chemother 1976;2:225-226.
10. Culebras E, Martinez JL. Aminoglycoside resistance mediated by the bifunctional enzyme 6′-N-aminoglycoside acetyl trans-ferase-2″-0- aminoglycoside phosphotransferase. Front Biosci 1999;4:D1-D8.
11. Gillespie MT, Lyon BR, Messerotti LJ, Skurray RA. Chromosome-and plasmid-mediated gentamicin resistance in Staphylococcus aureus encoded by Tn4001. J Med Microbiol 1987;24: 139-144.
12. Udo EE, Grubb WB. Transposition of genes encoding kana-mycin, neomycin and streptomycin resistance in Staphylococcus aureus. J Antimicrob Chemother 1991;27:713-720
13. Derbise A, Dyke KG, el Solh N. Characterization of a Staphylococcus aureus transposon, Tn5405, located within Tn5404 and carrying the aminoglycoside resistance genes, aphA-3 and aadE. Plasmid 1996;35:174-188.
14. Byrne ME, Gillespie MT, Skurray RA. 4′,4″ Adenyltransferase activity on conjugative plasmids isolated from Staphylococcus aureus is encoded on an integrated copy of pUBHO. Plasmid 1991;25:70-75.
15. Schmitz FJ, Sadurski R, Kray A, Boos M, Geisel R, Kohrer K, Verhoef J, Fluit AC. Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals. J Antimicrob Chemother 2000;45:891-894.
16. Weisblum B, Demohn V. Erythromycin-inducible resistance in Staphylococcus aureus: Survey of antibiotic classes involved. J Bacteriol 1969;98:447-452.
17. Westh H, Hougaard DM, Vuust J, Rosdahl VT. Prevalence of erm gene classes in erythromycin-resistant Staphylococcus aureus strains isolated between 1959 and 1988. Antimicrob Agents Chemother 1995;39:369-373.
18. Lina G, Quaglia A, Reverdy ME, Leclercq R, Vandenesch F, Etienne J. Distribution of genes encoding resistance to rnacro-lides, lincosamides, and streptogramins among staphylococci. Antimicrob Agents Chemother 1999;43:1062-1066.
19. NCCLS.Performance standards for antimicrobial susceptibility testing: 12th informational supplement. NCCLS Document M100-S14. NCCLS, 2004, Wayne, PA.
20. Arciola CR, Baldassarri L, Montanaro L. Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections. J Clin Microbiol 2001;39:2151-2156.
21. Ida T, Okamoto R, Shimauchi C, Okubo T, Kuga A, Inoue M. Identification of aminoglycoside-modifying enzymes by susceptibility testing: Epidemiology of methicillin-resistant Staphylococcus aureus in Japan. J Clin Microbiol 2001;39:3115-3121.
22. Strommenger B, Kettlitz C, Werner G, Witte W. Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus. J Clin Microbiol 2003;41:4089-4094.
23. Phillips I, King A, Shannon K. Prevalence and mechanisms of aminoglycoside resistance. A ten-year study. Am I Med B 1986;80:48-55.
24. Ardic N, Sareyyupoglu B, Ozyurt M, Haznedaroglu T, Ilga U. Investigation of aminoglycoside modifying enzyme genes in methicillin-resistant staphylococci. Microbiol Res 2006;161: 49-54.
25. Schmitz FJ, Fluit AC, Gondolf M, Beyrau R, Lindenlauf E, Verhoef J, Heinz HP, lones ME. The prevalence of aminoglycoside resistance and corresponding resistance genes in clinical isolates of staphylococci from 19 European hospitals. J Antimicrob Chemother. 1999;43:253-259.
26. Klingenberg C, Sundsfjord A, Ronnestad A, Mikalsen J, Gaustad P, Flaegstad T. Phenotypic and genotypic aminoglycoside resistance in blood culture isolates of coagulase-nega-tive staphylococci from a single neonatal intensive care unit, 1989-2000. J Antimicrob Chemother 2004;54:889-896.
27. Campoccia D, Montanaro L, Baldassarri L, An YH, Arciola CR. Antibiotic resistance in Staphylococcus aureus and Staphylococcus epidermidis clinical isolates from implant orthopedic infections. Int J Artif Organs 2005;28:1186-1191.
28. Choi SM, Kim SH, Kim HJ, Lee DG, Choi JH, Yoo JH, Kang JH, Shin WS, Kang MW. Multiplex PCR for the detection of genes encoding aminoglycoside modifying enzymes and methicillin resistance among Staphylococcus species. J Korean Med Sci 2003;18:631-636.
29. Vanhoof R, Godard C, Content }, Nyssen HJ, Hannecart-Pokorni E. Detection by polymerase chain reaction of genes encoding aminoglycoside-modifying enzymes in methicillin-resistant Staphylococcus aureus isolates of epidemic phage types. Belgian Study Group of Hospital Infections (GDEPIH/ GOSPIZ). J Med Microbiol 1994;41:282-290.
30. Martineau F, Picard FJ, Grenier L, Roy PH, Ouellette M, Bergeron MG. Multiplex PCR assays for the detection of clinically relevant antibiotic resistance genes in staphylococci isolated from patients infected after cardiac surgery. The ESPRIT trial. J Antimicrob Chemother 2000;46:527-534.
31. Eady EA, Ross JI, Tipper JL, Walters CE, Cove JH, Noble WC. Distribution of genes encoding erythromycin ribosomal methylases and an erythromycin efflux pump in epidemio-logically distinct groups of staphylococci. J Antimicrob Chemother 1993;31:211-217.
32. Tunney MM, Dunne N, Einarsson G, McDowell A, Kerr A, Patrick S. Biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis. J Orthop Res 2007; 25:2-10.
33. Arciola CR, Alvi FI, An YH, Campoccia D, Montanaro L. Implant infection and infection resistant materials: A mini review. Int J Artif Organs 2005;28:1119-1125.
34. von Eiff C, Arciola CR, Montanaro L, Becker K, Campoccia D. Emerging Staphylococcus species as new pathogens in implant infections. Int J Artif Organs 2006;29:360-367.