What are the important risk factors for healthcare-associated pneumonia?

Seminars in Respiratory and Critical Care Medicine

Volumn 30, Issue 1, 2009, Pages 26-35

  Poch, David S ^a   Ost, David E ^b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Drug resistant bacteria; Healthcare associated pneumonia; MRSA; Pneumonia; Pneumonia epidemiology; Staphylococcus aureus

Indexed keywords

COTRIMOXAZOLE;

AGE DISTRIBUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; CANCER CHEMOTHERAPY; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; DAILY LIFE ACTIVITY; DECUBITUS; DRUG EXPOSURE; ENVIRONMENTAL FACTOR; FUNCTIONAL STATUS; GRAM NEGATIVE INFECTION; HEALTH CARE DELIVERY; HEALTHCARE ASSOCIATED PNEUMONIA; HEMODIALYSIS; HOSPITAL INFECTION; HUMAN; INFECTION RISK; INFECTIOUS PNEUMONIA; LENGTH OF STAY; LONG TERM CARE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRACTICE GUIDELINE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW; RISK FACTOR; VENTILATOR ASSOCIATED PNEUMONIA; WOUND;

CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY; HOSPITALS; HUMANS; LONG-TERM CARE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; NURSING HOMES; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RENAL DIALYSIS; RESPIRATION, ARTIFICIAL; RISK FACTORS; STAPHYLOCOCCAL INFECTIONS; VENTILATORS, MECHANICAL;

EID: 60549102465     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0028-1119806     Document Type: Review

References (50)

1. American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare- associated pneumonia. Am J Respir Crit Care Med 2005; 171:388-416
2. Micek ST, Lloyd AE, Ritchie DJ, et al. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother 2005;49:1306-1311
3. Ibrahim EH, Ward S, Sherman G, et al. A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting. Chest 2000;117:1434-1442
4. Kollef MH. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients. Clin Infect Dis 2000;31(Suppl 4):S131-S138
5. Luna CM, Vujacich P, Niederman MS, et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997;111:676-685
6. Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-Acquired Pneumonia Study Group. Intensive Care Med 1996;22:387-394
7. Rello J, Gallego M, Mariscal D, et al. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 1997;156:196-200
8. Kollef MH, Ward S. The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 1998;113:412-420
9. Ibrahim EH, Ward S, Sherman G, et al. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med 2001;29:1109-1115
10. Morin CA, Hadler JL. Population-based incidence and characteristics of community-onset Staphylococcus aureus infections with bacteremia in 4 metropolitan Connecticut areas, 1998. J Infect Dis 2001;184:1029-1034
11. Friedman ND, Kaye KS, Stout JE, et al. Health care- associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002;137:791-797
12. Arancibia F, Bauer TT, Ewig S, et al. Community-acquired pneumonia due to gram-negative bacteria and Pseudomonas aeruginosa: incidence, risk, and prognosis. Arch Intern Med 2002;162:1849-1858
13. Pop-Vicas AE, D'Agata EM. The rising influx of multidrug- resistant gram-negative bacilli into a tertiary care hospital. Clin Infect Dis 2005;40:1792-1798
14. Carratala J, Mykietiuk A, Fernandez-Sabe N, et al. Healthcare-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy, and clinical outcomes. Arch Intern Med 2007;167:1393-1399
15. Micek ST, Kollef KE, Reichley RM, Roubinian N, Kollef MH. Healthcare-associated pneumonia and community- acquired pneumonia: a single center experience. Antimicrob Agents Chemother 2007;51:3568-3573
16. Kollef MH, Shorr A, Tabak YP, et al. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 2005;128:3854-3862
17. Marrie TJ, Blanchard W. A comparison of nursing home- acquired pneumonia patients with patients with community- acquired pneumonia and nursing home patients without pneumonia. J Am Geriatr Soc 1997;45:50-55
18. Janssens JP, Gauthey L, Herrmann F, et al. Community- acquired pneumonia in older patients. J Am Geriatr Soc 1996;44:539-544
19. Muder RR. Pneumonia in residents of long-term care facilities: epidemiology, etiology, management, and prevention. Am J Med 1998;105:319-330
20. Loeb MB, Craven S, McGeer AJ, et al. Risk factors for resistance to antimicrobial agents among nursing home residents. Am J Epidemiol 2003;157:40-47
21. El-Solh AA, Sikka P, Ramadan F, et al. Etiology of severe pneumonia in the very elderly. Am J Respir Crit Care Med 2001;163:645-651
22. El-Solh AA, Aquilina AT, Dhillon RS, et al. Impact of invasive strategy on management of antimicrobial treatment failure in institutionalized older people with severe pneumonia. Am J Respir Crit Care Med 2002;166:1038-1043
23. Sund-Levander M, Ortqvist A, Grodzinsky E, et al. Morbidity, mortality and clinical presentation of nursing home-acquired pneumonia in a Swedish population. Scand J Infect Dis 2003;35:306-310
24. MacArthur RD, Lehman MH, Currie-McCumber CA, et al. The epidemiology of gentamicin-resistant Pseudomonas aeruginosa on an intermediate care unit. Am J Epidemiol 1988;128:821-827
25. Wingard E, Shlaes JH, Mortimer EA, et al. Colonization and cross-colonization of nursing home patients with trimethoprim-resistant gram-negative bacilli. Clin Infect Dis 1993;16:75-81
26. Washio M, Nishisaka S, Kishikawa K, et al. Incidence of methicillin-resistant Staphylococcus aureus (MRSA) isolation in a skilled nursing home: a third report on the risk factors for the occurrence of MRSA infection in the elderly. J Epidemiol 1996;6:69-73
27. Muder RR, Brennen C, Drenning SD, et al. Multiply antibiotic-resistant gram-negative bacilli in a long-term-care facility: a case-control study of patient risk factors and prior antibiotic use. Infect Control Hosp Epidemiol 1997;18:809-813
28. Terpenning MS, Bradley SF, Wan JY, et al. Colonization and infection with antibiotic-resistant bacteria in a long- term care facility. J Am Geriatr Soc 1994;42:1062-1069
29. Gaynes RP, Weinstein RA, Chamberlin W, et al. Antibiotic- resistant flora in nursing home patients admitted to the hospital. Arch Intern Med 1985;145:1804-1807
30. Trick WE, Weinstein RA, DeMarais PL, et al. Colonization of skilled-care facility residents with antimicrobial-resistant pathogens. J Am Geriatr Soc 2001;49:270-276
31. Ewig S, Torres A, El-Ebiary M, et al. Bacterial colonization patterns in mechanically ventilated patients with traumatic and medical head injury: incidence, risk factors, and association with ventilator-associated pneumonia. Am J Respir Crit Care Med 1999;159:188-198
32. Lim WS, Macfarlane JT. A prospective comparison of nursing home acquired pneumonia with community acquired pneumonia. Eur Respir J 2001;18:362-368
33. El Solh AA, Pietrantoni C, Bhat A, et al. Indicators of potentially drug-resistant bacteria in severe nursing home-acquired pneumonia. Clin Infect Dis 2004;39:474-480
34. Yakovlev SV, Stratchounski LS, Woods GL, et al. Ertapenem versus cefepime for initial empirical treatment of pneumonia acquired in skilled-care facilities or in hospitals outside the intensive care unit. Eur J Clin Microbiol Infect Dis 2006;25:633-641
35. Maruyama T, Niederman MS, Kobayashi T, et al. A prospective comparison of nursing home-acquired pneumonia with hospital-acquired pneumonia in non-intubated elderly. Respir Med 2008;102:1287-1295
36. Slinin Y, Foley RN, Collins AJ. Clinical epidemiology of pneumonia in hemodialysis patients: the USRDS waves 1, 3, and 4 study. Kidney Int 2006;70:1135-1141
37. Sarnak MJ, Jaber BL. Pulmonary infectious mortality among patients with end-stage renal disease. Chest 2001;120:1883-1887
38. Vanholder R, Ringoir S. Infectious morbidity and defects of phagocytic function in end-stage renal disease: a review. J Am Soc Nephrol 1993;3:1541-1554
39. Cendoroglo M, Jaber BL, Balakrishnan VS, et al. Neutrophil apoptosis and dysfunction in uremia. J Am Soc Nephrol 1999;10:93-100
40. von Baum H, Ober JF, Wendt C, et al. Antibiotic-resistant bloodstream infections in hospitalized patients: specific risk factors in a high-risk population? Infection 2005;33:320-326
41. Glasmacher A, von Lilienfeld-Toal M, Schulte S, et al. An evidence-based evaluation of important aspects of empirical antibiotic therapy in febrile neutropenic patients. Clin Microbiol Infect 2005;11(Suppl 5):17-23
42. Maschmeyer G, Braveny I. Review of the incidence and prognosis of Pseudomonas aeruginosa infections in cancer patients in the 1990s. Eur J Clin Microbiol Infect Dis 2000;19:915-925
43. Freifeld A, Marchigiani D, Walsh T, et al. A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy. N Engl J Med 1999;341:305-311
44. Neuburger S, Maschmeyer G. Update on management of infections in cancer and stem cell transplant patients. Ann Hematol 2006;85:345-356
45. Hachem R, Raad I. Prevention and management of long- term catheter related infections in cancer patients. Cancer Invest 2002;20:1105-1113
46. Patel PJ, Leeper KV Jr, McGowan JE Jr. Epidemiology and microbiology of hospital-acquired pneumonia. Semin Respir Crit Care Med 2002;23:415-425
47. Sopena N, Sabria M. Multicenter study of hospital-acquired pneumonia in non-ICU patients. Chest 2005;127:213-219
48. Craven DE. What is healthcare-associated pneumonia, and how should it be treated? Curr Opin Infect Dis 2006;19:153-160
49. Cook DJ, Walter SD, Cook RJ, et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 1998;129:433-440
50. Laheij RJ, Sturkenboom MC, Hassing RJ, et al. Risk of community-acquired pneumonia and use of gastric acid- suppressive drugs. JAMA 2004;292:1955-1960