Concurrent chemoradiotherapy with gemcitabine plus regional hyperthermia for locally advanced pancreatic carcinoma: Initial experience

Radiation Medicine - Medical Imaging and Radiation Oncology

Volumn 26, Issue 10, 2008, Pages 587-596

  Ohguri, Takayuki ^a   Imada, Hajime ^a   Yahara, Katsuya ^a   Narisada, Hiroyuki ^b   Morioka, Tomoaki ^a   Nakano, Keita ^a   Korogi, Yukunori ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b Tobata Hospital   (Japan)

Author keywords

Chemotherapy; Gemcitabine; Hyperthermia; Pancreatic carcinoma; Radiotherapy

Indexed keywords

FLUOROURACIL; GEMCITABINE; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG DERIVATIVE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL EVALUATION; COLITIS; CONTROL GROUP; CONTROLLED STUDY; DIARRHEA; DISEASE COURSE; DISEASE FREE SURVIVAL; DRUG EFFICACY; FATIGUE; FEMALE; HEMATOLOGIC DISEASE; HUMAN; HYPERTHERMIA; LEUKOPENIA; MALE; NEUTROPENIA; OVERALL SURVIVAL; PANCREAS CARCINOMA; RADIATION DOSE; STOMACH ULCER; THROMBOCYTOPENIA; TREATMENT OUTCOME; ADENOCARCINOMA; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; EVALUATION; FOLLOW UP; HYPERTHERMIC THERAPY; METHODOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PANCREAS TUMOR; RETROSPECTIVE STUDY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, PANCREATIC DUCTAL; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HEMATOLOGIC DISEASES; HUMANS; HYPERTHERMIA, INDUCED; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 60549101219     PISSN: 02882043     EISSN: 18625274     Source Type: Journal    
DOI: 10.1007/s11604-008-0279-y     Document Type: Article

References (39)

1. D.M. Kelly I.S. Benjamin 1995 Pancreatic carcinoma Ann Oncol 6 19 28
2. S.L. Parker T. Tong S. Bolden P.A. Wingo 1996 Cancer statistics, 1996 CA CancerJ Clin 46 5 27
3. Gastrointestinal Tumor Study Group. 1988 Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone J Natl Cancer Inst 80 751 755
4. H.A. Burris 3rd M.J. Moore J. Andersen M.R. Green M.L. Rothenberg M.R. Modiano 1997 Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 2403 2413
5. D.S. Shewach T.S. Lawrence 1996 Gemcitabine and radiosensitization in human tumor cells Invest New Drugs 14 257 263
6. A.W. Blackstock S.A. Bernard F. Richards K.S. Eagle L.D. Case M.E. Poole 1999 Phase I trial of twice-weekly gemcitabine and concurrent radiation in patients with advanced pancreatic cancer J Clin Oncol 17 2208 2212
7. J.M. Pipas S.E. Mitchell R.J. Barth Jr R. Vera-Gimon J. Rathmann L.P. Meyer 2001 Phase I study of twice-weekly gemcitabine and concomitant external-beam radiotherapy in patients with adenocarcinoma of the pancreas Int J Radiat Oncol Biol Phys 50 1317 1322
8. Epelbaum R, Rosenblatt E, Nasrallah S, Faraggi D, Gaitini D, Mizrahi S, et al. A phase II study of gemcitabine (GEM) combined with radiation therapy (RT) in patients with localized, unresectable pancreatic cancer. Proc Am Soc Clin Oncol 2000;19:A1029 (abstract).
9. M.S. Talamonti P.J. Catalano D.J. Vaughn R. Whittington R.D. Beauchamp J. Berlin 2000 Eastern Cooperative Oncology Group phase I trial of protracted venous infusion fluorouracil plus weekly gemcitabine with concurrent radiation therapy in patients with locally advanced pancreas cancer: a regimen with unexpected early toxicity J Clin Oncol 18 3384 3389
10. A.A. Yavuz F. Aydin M.N. Yavuz E. Ilis F. Ozdemir 2001 Radiation therapy and concurrent fixed dose amifostine with escalating doses of twice-weekly gemcitabine in advanced pancreatic cancer Int J Radiat Oncol Biol Phys 51 974 981
11. G.V. Kornek R. Potter E. Selzer A. Schratter H. Ulrich-Pur M. Rogy 2001 Combined radiochemotherapy of locally advanced unresectable pancreatic adenocarcinoma with mitomycin C plus 24-hour continuous infusional gemcitabine Int J Radiat Oncol Biol Phys 49 665 671
12. C.J. McGinn M.M. Zalupski I. Shureiqi J.M. Robertson F.E. Eckhauser D.C. Smith 2001 Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer J Clin Oncol 19 4202 4208
13. S.M. De Lange C.J. van Groeningen O.W. Meijer M.A. Cuesta J.A. Langendijk J.M. van Riel 2002 Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer Eur J Cancer 38 1212 1217
14. C.P. Li Y. Chao K.H. Chi W.K. Chan H.C. Teng R.C. Lee 2003 Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine versus 5-fluorouracil, a randomized controlled study Int J Radiat Oncol Biol Phys 57 98 104
15. 2 gemcitabine can be administered using limited-field radiotherapy Strahlenther Onkol 183 301 306
16. Jones EL, Samulski TV, Vujaskovic Z, Leonard RP, Dewhirst MW. Hyperthermia. In: Perez CA, Brady LW, Halperin EC, Schmidt-Ullrich RK, editors. Principles and practice of radiation oncology. 4th edition. Philadelphia: Lippincott Williams & Wilkins; 2003. p. 699-735.
17. M. Urano M. Kuroda Y. Nishimura 1999 For the clinical application of thermochemotherapy given at mild temperatures Int J Hyperthermia 15 79 107
18. F. Mohamed P. Marchettini O.A. Stuart M. Urano P.H. Sugarbaker 2003 Thermal enhancement of new chemotherapeutic agents at moderate hyperthermia Ann Surg Oncol 10 463 468
19. J. Haveman R.C. Rietbroek A. Geerdink J. Van Rijn P.J. Bakker 1995 Effect of hyperthermia on the cytotoxicity of 2′,2′- difluorodeoxycytidine (gemcitabine) in cultured SW1573 cells Int J Cancer 62 627 630
20. R.A. Vertrees G.C. Das V.L. Popov A.M. Coscio T.J. Goodwin R. Logrono 2005 Synergistic interaction of hyperthermia and gemcitabine in lung cancer Cancer Biol Ther 4 1144 1153
21. S. Miyazaki M. Izukura J. Nishizima 2004 Clinical appraisal of hyperthermic treatment combined with low dose of gemcitabine hydrochloride for the unresectable pancreas cancer Jpn J Hyperthermic Oncol 20 161 169
22. Sobin LH, Wittekind CH. UICC TNM classification of malignant tumors. 5th edition. Berlin: Springer; 1997.
23. C.W. Song J.G. Rhee C.K. Lee S.H. Levitt 1986 Capacitive heating of phantom and human tumors with an 8 MHz radiofrequency applicator (Thermotron RF-8) Int J Radiat Oncol Biol Phys 12 365 372
24. C.K. Lee C.W. Song J.G. Rhee J.A. Foy S.H. Levitt 1995 Clinical experience using 8 MHz radiofrequency capacitive hyperthermia in combination with radiotherapy: results of a phase I/II study Int J Radiat Oncol Biol Phys 32 733 745
25. R. Hamazoe M. Maeta A. Murakami H. Yamashiro N. Kaibara 1991 Heating efficiency of radiofrequency capacitive hyperthermia for treatment of deep-seated tumors in the peritoneal cavity J Surg Oncol 48 176 179
26. Imada H. Development of new heating technique. In: Matsuda T, Sugawara T, Abe M, Tanaka Y, editors. Hyperthermia No Rinsho. Tokyo: Iryokagaku; 1999. p. 394-402.
27. B. Rau P. Wust P. Hohenberger J. Löffel M. Hünerbein C. Below 1998 Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: a phase II clinical trial Ann Surg 227 380 389
28. E.L. Jones T.V. Samulski M.W. Dewhirst A. Alvarez-Secord A. Berchuck D. Clarke-Pearson 2003 A pilot phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma Cancer 98 277 282
29. V.E. Kouloulias J.R. Kouvaris K.S. Nikita B.C. Golematis N.K. Uzunoglu K. Mystakidou 2002 Intraoperative hyperthermia in conjunction with multi-schedule chemotherapy (pre-, intra- and post-operative), by-pass surgery, and postoperative radiotherapy for the management of unresectable pancreatic adenocarcinoma Int J Hyperthermia 18 233 252
30. E. Ashayeri G. Bonney R.L. DeWitty A.L. Goldson L.D. Leffall J.N. Thomas 1993 Preliminary survivorship report on combined intraoperative radiation and hyperthermia treatments for unresectable pancreatic adenocarcinoma J Natl Med Assoc 85 36 40
31. M. Kakehi K. Ueda T. Mukojima M. Hiraoka O. Seto A. Akanuma 1990 Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs Int J Hyperthermia 6 719 740
32. C.G. Moertel D.S. Childs Jr R.J. Reitemeier M.Y. Colby Jr M.A. Holbrook 1969 Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer Lancet 2 865 867
33. C.G. Moertel S. Frytak R.G. Hahn M.J. O'Connell R.J. Reitemeier J. Rubin 1981 Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads +5- fluorouracil), and high dose radiation +5-fluorouracil: the Gastrointestinal Tumor Study Group Cancer 48 1705 1710
34. H.J. Feldmann M.H. Seegenschmiedt M. Molls 1995 Hyperthermia-its actual role in radiation oncology. Part III. Clinical rationale and results in deep seated tumors Strahlenther Onkol 171 251 264
35. J. Van der Zee D. Gonzalez Gonzalez G.C. Van Rhoon J.D. Van Dijk W.L. Van Putten A.A. Hart 2000 Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial; Dutch Deep Hyperthermia Group Lancet 355 1119 1125
36. R.D. Issels S. Abdel-Rahman C. Wendtner M.H. Falk V. Kurze H. Sauer 2001 Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study Eur J Cancer 37 1599 1608
37. R. De Wit J. van der Zee M.E. van der Burg W.H. Kruit A. Logmans G.C. van Rhoon 1999 A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix Br J Cancer 80 1387 1391
38. C.W. Song H. Park R.J. Griffin 2001 Improvement of tumor oxygenation by mild hyperthermia Radiat Res 155 515 528
39. E.L. Jones L.R. Prosnitz M.W. Dewhirst P.K. Marcom P.H. Hardenbergh L.B. Marks 2004 Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer Clin Cancer Res 10 4287 4293