Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice

Journal of Pathology

Volumn 217, Issue 3, 2009, Pages 362-371

  Xu, H ^a   Noria, F ^a   Sandoval Cooper, M J ^a   Menchen, H ^a   Donahue, D L ^a   Ploplis, V A ^a   Castellino, F J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Animal models of human disease; Cardiac failure; Cardiomyopathy; Coagulation; Cytokines; Endothelium; Factor VII; Fibrosis; Gene altered mice; Left ventricle; Metalloproteinases; Systolic dysfunction; Vascular leakage

Indexed keywords

BLOOD CLOTTING FACTOR 7; COLLAGEN; HEMOSIDERIN; MATRIX METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING FACTOR 7 DEFICIENCY; COLLAGEN SYNTHESIS; CONTROLLED STUDY; HEART MUSCLE FIBROSIS; HEART MUSCLE NECROSIS; HEART VENTRICLE REMODELING; HEART VENTRICLE SIZE; LEUKOCYTE AGGREGATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESTRICTIVE CARDIOMYOPATHY; ANIMAL; BLEEDING; C57BL MOUSE; CHEMISTRY; DOPPLER ECHOCARDIOGRAPHY; FIBROSIS; HEART DISEASE; HEART MUSCLE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; COLLAGEN; ECHOCARDIOGRAPHY, DOPPLER; FACTOR VII DEFICIENCY; FIBROSIS; HEART DISEASES; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MYOCARDIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 60549099175     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2454     Document Type: Article

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