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European Biophysics Journal

Volumn 38, Issue 3, 2009, Pages 273-278

High throughput functional screening of an ion channel library for drug safety and efficacy

(1) Brown, Arthur M a

a ChanTest Corporation (United States)

Author keywords

Automated fluorescence; Automated patch clamp; Cardiac channel panel ; High throughput screening; Ion channel library

Indexed keywords

ANIMALS; AUTOMATION; CELL LINE; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; ION CHANNELS; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY;

EID: 60549097707 PISSN: 01757571 EISSN: None Source Type: Journal
DOI: 10.1007/s00249-008-0356-2 Document Type: Review

Times cited : (12)

References (7)

1
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- Drug-induced long QT syndrome: Is HERG the root of all evil?
- AM Brown D Rampe 2000 Drug-induced long QT syndrome: is HERG the root of all evil? Pharm News 7 15 20
- (2000) Pharm News , vol.7 , pp. 15-20
- Brown, A.M.¹ Rampe, D.²

2
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- Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulation patterns
- 10.1016/j.vascn.2004.06.003
- GE Kirsch ES Trepakova JC Brimecombe SS Sidach HD Erickson MC Kochan 2004 Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulation patterns J Pharmacol Toxicol Methods 50 93 101 10.1016/j.vascn.2004.06.003
- (2004) J Pharmacol Toxicol Methods , vol.50 , pp. 93-101
- Kirsch, G.E.¹ Trepakova, E.S.² Brimecombe, J.C.³ Sidach, S.S.⁴ Erickson, H.D.⁵ Kochan, M.C.⁶

3
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- Alfuzosin delays cardiac repolarization by a novel mechanism
- 10.1124/jpet.107.128405
- AE Lacerda YA Kuryshev Y Chen M Renganathan H Eng SJ Danthi 2008 Alfuzosin delays cardiac repolarization by a novel mechanism J Pharmacol Exp Ther 324 427 433 10.1124/jpet.107.128405
- (2008) J Pharmacol Exp Ther , vol.324 , pp. 427-433
- Lacerda, A.E.¹ Kuryshev, Y.A.² Chen, Y.³ Renganathan, M.⁴ Eng, H.⁵ Danthi, S.J.⁶

4
- 60549089464
- NIH scientist session
- Lacerda AE, Matsumoto N, Khrestian CM, Ryu K, Yan GX, Waldo AL, et al. (2005) Effects of CT-1 on cardiac ion channels. NIH scientist session
- (2005) Effects of CT-1 on Cardiac Ion Channels
- Lacerda, A.E.¹ Matsumoto, N.² Khrestian, C.M.³ Ryu, K.⁴ Yan, G.X.⁵ Waldo, A.L.⁶

5
- 60549095723
- W•H. Freeman & Co New York
- th edn. W•H. Freeman & Co, New York
- (2000)
- Lodish, H.¹ Berk, A.² Zipursky, S.L.³ Matsudaira, P.⁴ Baltimore, D.⁵ Darnell, J.E.⁶

6
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- Variability of the QTc interval: Impact on defining drug effect and low-frequency cardiac event
- 10.1016/0002-9149(93)90037-D
- J Morganroth AM Brown S Critz WJ Crumb DL Kunze AE Lacerda 1993 Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event Am J Cardiol 72 26B 31B 10.1016/0002-9149(93)90037-D
- (1993) Am J Cardiol , vol.72
- Morganroth, J.¹ Brown, A.M.² Critz, S.³ Crumb, W.J.⁴ Kunze, D.L.⁵ Lacerda, A.E.⁶

7
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- HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
- ML Roy R Dumaine AM Brown 1996 HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine Circulation 94 817 823
- (1996) Circulation , vol.94 , pp. 817-823
- Roy, M.L.¹ Dumaine, R.² Brown, A.M.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.