Short-term electrophysiological effects of losartan, bisoprolol, amlodipine, and hydrochlorothiazide in hypertensive men

Annals of Medicine

Volumn 41, Issue 1, 2009, Pages 29-37

  Porthan, Kimmo ^a   Viitasalo, Matti ^a   Hiltunen, Timo P ^a   Väänänen, Heikki ^a   Dabek, Juhani ^a   Suonsyrjä, Timo ^a   Hannila Handelberg, Tuula ^a   Virolainen, Juha ^a   Nieminen, Markku S ^a   Toivonen, Lauri ^a   Kontula, Kimmo ^a   Oikarinen, Lasse ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Antihypertensive drugs; Electrocardiography; Hypertension; Repolarization

Indexed keywords

AMLODIPINE; BISOPROLOL; HYDROCHLOROTHIAZIDE; LOSARTAN; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELECTROCARDIOGRAM; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; T WAVE;

ACTION POTENTIALS; AMLODIPINE; ANTIHYPERTENSIVE AGENTS; BISOPROLOL; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; LOSARTAN; MALE; MIDDLE AGED; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION;

EID: 60549096880     PISSN: 07853890     EISSN: 16512219     Source Type: Journal    
DOI: 10.1080/07853890802195211     Document Type: Article

References (41)

1. Haider AW, Larson MG, Benjamin EJ, Levy D. Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol. 1998;32:1454-9.
2. Kowey PR, Friechling TD, Sewter J, Wu Y, Sokil A, Paul J, et al. Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade. Circulation. 1991;83:2067-75.
3. Ben-David J, Zipes DP, Ayers GM, Pride HP. Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644. J Am Coll Cardiol. 1992;20:1576-84.
4. Yan GX, Rials SJ, Wu Y, Liu T, Xu X, Marinchak RA, et al. Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization. Am J Physiol Heart Circ Physiol. 2001;281:H1968-75.
5. Kozhevnikov DO, Yamamoto K, Robotis D, Restivo M, El-Sherif N. Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns. Circulation. 2002;105:1128-34.
6. Porthan K, Virolainen J, Hiltunen TP, Viitasalo M, Väänä nen H, Dabek J, et al. Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension. J Hypertens. 2007;25: 1951-7.
7. Schoenmakers M, Ramakers C, van Opstal JM, Leunissen JD, Londono C, Vos MA. Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog. Cardiovasc Res. 2003;59:351-9.
8. Perrier E, Kerfant BG, Lalevee N, Bideaux P, Rossier MF, Richard S, et al. Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction. Circulation. 2004;110:776-83.
9. Okin PM, Devereux RB, Jern S, Kjeldsen SE, Julius S, Nieminen MS, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events. JAMA. 2004;292:2343-9.
10. Oikarinen L, Nieminen MS, Toivonen L, Viitasalo M, Wachtell K, Papademetriou V, et al. Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention For Endpoint Reduction (LIFE) study. Am Heart J. 2003;145:919-25.
11. Delpon E, Caballero R, Gomez R, Nunez L, Tamargo J. Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization. Trends Pharmacol Sci. 2005;26:155-61.
12. Fischer R, Dechend R, Gapelyuk A, Shagdarsuren E, Gruner K, Gruner A, et al. Angiotensin II-induced sudden arrhythmic death and electrical remodeling. Am J Physiol Heart Circ Physiol. 2007;293:H1242-53.
13. Domenighetti AA, Boixel C, Cefai D, Abriel H, Pedrazzini T. Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation. J Mol Cell Cardiol. 2007;42:63-70.
14. Burnier M, Brunner HR. Neurohormonal consequences of diuretics in different cardiovascular syndromes. Eur Heart J. 1992;13 Suppl G:S28-33.
15. Siscovick DS, Raghunathan TE, Psaty BM, Koepsell TD, Wicklund KG, Lin X, et al. Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med. 1994;330:1852-7.
16. Hoes AW, Grobbee DE, Lubsen J, Man in 't Veld AJ, van der Does E, Hofman A. Diuretics, beta-blockers, and the risk for sudden cardiac death in hypertensive patients. Ann Intern Med. 1995;123:481-7.
17. Viitasalo M, Oikarinen L, Swan H, Väänänen H, Järvenpää J, Hietanen H, et al. Effects of beta-blocker therapy on ventricular repolarization documented by 24-h electrocardiography in patients with type 1 long-QT syndrome. J Am Coll Cardiol. 2006;48:747-53.
18. Roden DM. Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med. 2006;259:59-69.
19. Hiltunen TP, Suonsyrjä T, Hannila-Handelberg T, Paavonen KJ, Miettinen HE, Strandberg T, et al. Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (the GENRES study). Am J Hypertens. 2007;20:311-8.
20. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450-8.
21. Liu JE, Devereux RB. Clinical assessment of cardiac hypertrophy. In: Sheridan DJ, editor. Left ventricular hypertrophy. London: Churchill Livingstone; 1998. p. 11-16.
22. Oikarinen L, Karvonen M, Viitasalo M, Takala P, Kaartinen M, Rossinen J, et al. Electrocardiographic assessment of left ventricular hypertrophy with time-voltage QRS and QRST-wave areas. J Hum Hypertens. 2004;18:33-40.
23. Oikarinen L, Paavola M, Montonen J, Viitasalo M, Mäkijärvi M, Toivonen L, et al. Magnetocardiographic QT interval dispersion in postmyocardial infarction patients with sustained ventricular tachycardia: validation of automated QT measurements. Pacing Clin Electrophysiol. 1998;21:1934-42.
24. Antzelevitch C, Fish J. Electrical heterogeneity within the ventricular wall. Basic Res Cardiol. 2001;96:517-27.
25. Zabel M, Portnoy S, Franz MR. Electrocardiographic indexes of dispersion of ventricular repolarization: an isolated heart validation study. J Am Coll Cardiol. 1995;25:746-52.
26. Karjalainen J, Viitasalo M, Mänttäri M, Manninen V. Relation between QT intervals and heart rates from 40 to 120 beats/min in rest electrocardiograms of men and a simple method to adjust QT interval values. J Am Coll Cardiol. 1994;23:1547-53.
27. Okin PM, Devereux RB, Fabsitz RR, Lee ET, Galloway JM, Howard BV. Principal component analysis of the T wave and prediction of cardiovascular mortality in American Indians: the Strong Heart Study. Circulation. 2002;105:714-9.
28. Acar B, Yi G, Hnatkova K, Malik M. Spatial, temporal and wavefront direction characteristics of 12-lead T-wave morphology. Med Biol Eng Comput. 1999;37:574-84.
29. Zabel M, Malik M, Hnatkova K, Papademetriou V, Pittaras A, Fletcher RD, et al. Analysis of T-wave morphology from the 12-lead electrocardiogram for prediction of long-term prognosis in male US veterans. Circulation. 2002;105:1066-70.
30. Zabel M, Acar B, Klingenheben T, Franz MR, Hohnloser SH, Malik M. Analysis of 12-lead T-wave morphology for risk stratification after myocardial infarction. Circulation. 2000;102:1252-7.
31. Okin PM, Roman MJ, Devereux RB, Pickering TG, Borer JS, Kligfield P. Time-voltage QRS area of the 12-lead electrocardiogram: detection of left ventricular hypertrophy. Hypertension. 1998;31:937-42.
32. Surawicz B. Electrocardiographic diagnosis of chamber enlargement. J Am Coll Cardiol. 1986;8:711-24.
33. Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007;292:C82-97.
34. Gonzalez-Juanatey JR, Garcia-Acuna JM, Pose A, Varela A, Calvo C, Cabezas-Cerrato J, et al. Reduction of QTand QTc dispersion during long-term treatment of systemic hypertension with enalapril. Am J Cardiol. 1998;81:170-4.
35. Rials SJ, Xu X, Wu Y, Liu T, Marinchack RA, Kowey PR. Restoration of normal ventricular electrophysiology in renovascular hypertensive rabbits after treatment with losartan. J Cardiovasc Pharmacol. 2001;37:317-23.
36. Malmqvist K, Kahan T, Edner M, Bergfedt L. Comparison of actions of irbesartan versus atenolol on cardiac repolarization in hypertensive left ventricular hypertrophy: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation Versus Atenolol (SILVHIA). Am J Cardiol. 2002;90:1107-12.
37. Caballero R, Delpon E, Valenzuela C, Longobardo M, Tamargo J. Losartan and its metabolite E3174 modify cardiac delayed rectifier K(+) currents. Circulation. 2000;101:1199-205.
38. Zicha S, Tsuji Y, Shiroshita-Takeshita A, Nattel S. Beta-blockers as antiarrhythmic agents. Handb Exp Pharmacol. 2006:235-66.
39. Priori SG, Napolitano C, Schwartz PJ, Grillo M, Bloise R, Ronchetti E, et al. Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA. 2004;292:1341-4.
40. Blumenfeld JD, Sealey JE, Mann SJ, Bragat A, Marion R, Pecker MS, et al. Beta-adrenergic receptor blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensive and hypertensive subjects. Am J Hypertens. 1999;12:451-9.
41. Eckardt L, Kirchhof P, Breithardt G, Haverkamp W. Load-induced changes in repolarization: evidence from experimental and clinical data. Basic Res Cardiol. 2001;96:369-80.