Dexmedetomidine as the primary sedative during invasive procedures in infants and toddlers with congenital heart disease

Pediatric Critical Care Medicine

Volumn 9, Issue 6, 2008, Pages 612-615

  Barton, Kristin P ^a,d   Munoz, Ricardo ^b,d   Morell, Victor O ^c,d   Chrysostomou, Constantinos ^b,d  

^a Department of Pediatrics

^b Department of Critical Care Medicine

^c Heart Diabetes and Week Lost Centers of New York   (United States)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; KETAMINE; OXYGEN; HYPNOTIC SEDATIVE AGENT;

ABDOMINAL DISTENSION; ADD ON THERAPY; ANESTHETIC RECOVERY; ARTICLE; BLOOD PRESSURE; BODY TEMPERATURE; BREATHING; CHILD; CLINICAL ARTICLE; CONGENITAL DIAPHRAGM HERNIA; CONGENITAL HEART DISEASE; FEMORAL VEIN; FIBEROPTIC BRONCHOSCOPY; HEART RATE; HUMAN; HYPERSALIVATION; INFANT; INTENSIVE CARE UNIT; INVASIVE PROCEDURE; LOW DRUG DOSE; MEDICAL RECORD REVIEW; OXYGEN TENSION; OXYGEN THERAPY; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEDATION; SUBCLAVIAN VEIN; TREATMENT DURATION; TUBE; VOMITING; BRONCHOSCOPY; CENTRAL VENOUS CATHETERIZATION; CONGENITAL HEART MALFORMATION; FEMALE; MALE; NEWBORN;

BRONCHOSCOPY; CATHETERIZATION, CENTRAL VENOUS; CHEST TUBES; CHILD, PRESCHOOL; DEXMEDETOMIDINE; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; HYPNOTICS AND SEDATIVES; INFANT; INFANT, NEWBORN; MALE; RETROSPECTIVE STUDIES;

EID: 60549084186     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31818d320d     Document Type: Article

References (20)

1. Chrysostomou C, Di Filippo S, Manrique AM, et al: Use of dexmedetomidine in children after cardiac and thoracic surgery. Pediatr Crit Care Med 2006; 7:126-131
2. Berkenbosch JW, Wnkum PC, Tobias JD: Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatr Crit Care Med 2005; 6:435-439
3. Venn RM, Hell J, Grounds RM: Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care Med 2000; 4:302-308
4. Krauss B, Green SM: Procedural sedation and analgesia in children. Lancet 2006; 367: 766-780
5. Malviya S, Voepel-Lewis T, Tait A: Adverse events and risk factors associated with the sedation of children by nonanesthesiologists. Anesth Analg 1997; 85:1207-1213
6. Chrysostomou C, Avolio T, Orr R, et al: Dexmedetomidine use in a pediatric cardiac intensive care unit: Can we safely use it in infants after cardiac surgery? Pediatr Crit Care Med 2007; 8:A308
7. Shukry M, Kennedy K: Dexmedetomidine as a total intravenous anesthetic in infants. Pediatr Anesth 2007; 17:581-583
8. Hamish MM, Tirotta CF, Felix DE, et al: Initial experience with dexmedetomidine for diagnostic and interventional cardiac catheterization in children. Pediatr Anesth 2007; 17:109-112
9. Oklu E, Bulutcu FS, Yalcin Y, et al: Which anesthetic agent alters the hemodynamic status during pediatric catheterization? Comparison of Propofol versus Ketamine. J Cardiothorac Vasc Anesth 2003; 17: 686-690
10. Gupta PK, Sehgal R, Gupta M, et al: Attenuation of cardiovascular responses to ket-amine: Comparative evaluation of lignocaine and clonidine. Indian J Anesth 2002; 46: 457-459
11. Munro HM, Sleigh JW, Paxton LD: The cardiovascular response to ketamine: The effects of clonidine and lignocaine. Abstr. Acta An-aesthesiologica Scandinavica 1993; 37: 75-78
12. Petroz GC, Sikich N, James M, et al: A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology 2006; 105: 1098-1110
13. Mukhtar AM, Obayah EM, Hassona AM: The use of dexmedetomidine in pediatric cardiac surgery. Anesth Analg 2006; 103:52-56
14. Szumita PM, Baroletti SA, Anger KE, et al: Sedation and analgesia in the intensive care unit: Evaluating the role of dexmedetomi-dine. Am J Health Syst Pharm 2007; 64: 37-44
15. Levanen J, Makela ML, Scheinin H: Dexme-detomidine premedication attenuates ket-amine-induced cardiostimulatory effects and postanesthetic delirium. Anesthesiology 1995; 82:1117-1125
16. Suzuki M, Tsueda K, Lansig P, et al: Small-dose ketamine enhances morphine-induced analgesia after outpatient surgery. Anesth Analg 1999; 89:98-103
17. Scheinin H, Aantaa R, Anttila M, et al: Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific al-pha2-adrenoceptor antagonist atipamezole: A pharmacodynamic and kinetic study in healthy volunteers. Abstr. Anesthesiology 1998; 89:574-584
18. Fanini D, Poglio M, Marci MC, et al: Oral premedication with clonidine as an alternative in dental practice. The effects on the pain threshold, blood pressure and salivary flow. Abstr. Minerva Stomatol 1998; 47:453-464
19. Precedex (Dexmedetomidine Hydrochloride) [package insert]. Lake Forest, IL, Hospira, 2004
20. Dyck JB, Maze M, Haack C, et al: The phar-macokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomi-dine hydrochloride in adult human volunteers. Anesthesiology 1993; 78: 813-820