Nonmelanoma skin cancer of the head and neck I: histopathology and clinical behavior

American Journal of Otolaryngology - Head and Neck Medicine and Surgery

Volumn 30, Issue 2, 2009, Pages 121-133

  McGuire, John F ^a   Ge, Norman N ^a   Dyson, Senait ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINIC KERATOSIS; BASAL CELL CARCINOMA; CANCER GROWTH; CANCER INCIDENCE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; DERMATOFIBROSARCOMA PROTUBERANS; HEAD AND NECK CANCER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE DISSECTION; MERKEL CELL TUMOR; METASTASIS; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SKIN CANCER; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME;

CARCINOMA; DERMATOFIBROSARCOMA; HEAD AND NECK NEOPLASMS; HUMANS; NEOPLASM METASTASIS; ORGAN TRANSPLANTATION; SKIN NEOPLASMS;

EID: 60449092062     PISSN: 01960709     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjoto.2008.03.002     Document Type: Review

References (124)

1. John Chen G., Yelverton C.B., Polisetty S.S., et al. Treatment patterns and cost of non-melanoma skin cancer management. Dermatol Surg 32 10 (2006) 1266-1271
2. Levi F., La Vecchia C., Te V.-C., et al. Descriptive epidemiology of skin cancer in the Swiss Canton of Vaud. Int J Cancer 42 (1988) 811-816
3. Leman J.A., and McHenry P.M. Basal cell carcinoma still an enigma. Arch Dermatol 137 (2001) 1239-1240
4. Bastiaens M.T., Hoefnagel J.J., Bruijn J.A., et al. Differences in age, site distribution, and sex between nodular and superficial basal cell carcinoma indicate different types of tumors. J Invest Dermatol 110 6 (1998) 880-884
5. Hutcheson A.C., Fisher A.H., and Lang Jr. P.G. Basal cell carcinomas with unusual histological patterns. J Am Acad Dermatol 53 5 (2005) 833-837
6. DeFaria J.L. Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma?. J Clin Pathol 38 (1985) 1273-1277
7. Borel D.M. Cutaneous basosquamous carcinoma. Review of the literature and report of 35 cases. Arch Pathol 95 (1973) 293-297
8. Burg G., Hirsch R.D., Konz B., et al. Histographic surgery: accuracy of visual assessment of the margins of basal-cell epithelioma. J Dermoatol Surg 1 (1975) 21
9. Salasche S.H., and Ammonette R.A. Morpheiform basal cell epitheliomas: a study of subclinical extensions in a series of 51 cases. J Dermatol Surg Oncol 7 (1981) 387
10. Jacobs G.H., Rippey J.J., and Altini M. Prediction of aggressive behavior in basal cell carcinoma. Cancer 49 (1982) 533-537
11. Lang Jr. P.G., and Maize J.C. Histological evolution of recurrent basal cell carcinoma and treatment implications. J Am Acad Dermatol 14 (1986) 186-196
12. Wade T.R., and Ackerman A.B. The many faces of basal cell carcinoma. J Dermatol Surg Oncol 4 (1978) 23-28
13. Emmett A.J.J., and Weedon D. Basal cell carcinoma. In: Emmett A.J.J., and O'Rourke M.G.E. (Eds). Malignant Skin Tumours (1982), Churchill Livingstone, New York 30-66
14. Siegle R.J., MacMillan J., and Pollack S.V. Infiltrative basal cell carcinoma: a nonsclerosing subtype. J Dermatol Surg Oncol 12 (1986) 830-836
15. Weedon D. Tumours of the epidermis. In: Weedon D. (Ed). The Skin (1992), Churchill Livingstone, Edinburgh 729-776
16. Ackerman A.B., DeViragh P.A., and Chongchitnant N. Neoplasms with follicular differentiation (1993), Lea & Febiger, Philadelphia 605-658
17. Scrivener Y., Grosshans E., and Cribier B. Variations of basal cell carcinomas according to gender, age, location and histopathological subtype. Br J Dermatol 147 1 (2002) 41-47
18. Scrivener Y., Grosshans E., and Cribier B. Variations of basal cell carcinomas according to gender, age, location and histopathological subtype. Cancer 98 12 (2003) 2708-2714
19. Von Domarus H., and Steven P.J. Metastatic basal cell carcinoma report of five cases and review of 170 cases in the literature. J Am Acad Dermatol 10 (1984) 1043-1060
20. Levine H.L., and Bailin P.L. Basal cell carcinoma of the head and neck: identification of the high risk patient. Laryngoscope 90 6 (1980) 955-961
21. Levin H.L. Cutaneous carcinoma of the head and neck: management of massive and previously uncontrolled lesions. Laryngoscope 93 1 (1983) 87-105
22. Bart R.S., Kopf A.W., and Petratos M.A. X-ray therapy of skin cancer: evaluation of a "standardized" method for treating basal-cell epitheliomas. Sixth National Cancer Conference Proceedings (1970), JP Lippincott, Philadelphia
23. Zagrodnik B, Kempf W, Seifert B, Muller B, Burg G, Urosevic M, Dummer R. Superficial radiotherapy for patients with basal cell carcinoma: recurrence rates, histologic subtypes, and expression of p53 and Bcl-2.
24. Marcil I., and Stern R.S. Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 136 12 (2000) 1524-1530
25. Miller D.L., and Weinstock M.A. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 30 5 Pt 1 (1994) 774-778
26. Armstrong B.K., and Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63 1-3 (2001) 8-18
27. de Gruijl F.R. Photocarcinogenesis: UVA vs UVB. Methods Enzymol 319 (2000) 359-366
28. Drolet B.A., Neuburg M., and Sanger J. Role of human papillomavirus in cutaneous oncogenesis. Ann Plast Surg 33 3 (1994) 339-347
29. Esther R.J., Lamps L., and Schwartz H.S. Marjolin ulcers: secondary carcinomas in chronic wounds. J South Orthop Assoc 8 3 (1999) 181-187
30. Perry P.K., and Silverberg N.B. Cutaneous malignancy in albinism. Cutis 67 5 (2001) 427-430
31. Czarnecki D., Meehan C.J., Bruce F., et al. The majority of cutaneous squamous cell carcinomas arise in actinic keratoses. J Cutan Med Surg 6 3 (2002) 207-209
32. Cassarino D.S., Derienzo D.P., and Barr R.J. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol 33 3 (2006) 191-206 [Review]
33. Wick M.R., Fitzgibbon J.F., and Swanson P.E. Cutaneous sarcomas and sarcomatoid neoplasms of the skin. Semin Diagn Pathol 10 (1993) 148-158
34. Bernstein S.C., Lim K.K., Brodland D.G., et al. The many faces of squamous cell carcinoma. Dermatol Surg 22 (1996) 243-254
35. Heintz P.W., and White Jr. C.R. Diagnosis-atypical fibroxanthoma or not? Evaluating spindle cell malignancies on sun damaged skin: a practical approach. Semin Cutan Med Surg 18 (1999) 78-83
36. Cassarino D.S., Derienzo D.P., and Barr R.J. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification-part two. J Cutan Pathol 33 4 (2006) 261-279 [Review]
37. Leibovitch I., Huilgol S.C., Selva D., et al. Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia II. Perineural invasion. J Am Acad Dermatol 53 2 (2005) 261-266
38. Levine H., Bailin P., Wood B., et al. Tissue conservation in treatment of cutaneous neoplasms of the head and neck: combined use of Mohs' chemosurgical and conventional surgical techniques. Arch Otolaryngol 105 (1979) 140-144
39. Levine J.L., and Bailin P.L. Basal cell carcinoma of the head and neck: identification of the high-risk patient. Laryngoscope 90 (1980) 955-961
40. Dinehart S.M., and Pollack S.V. Metastases from squamous cell carcinoma of the skin and lip. J Am Acad Dermatol 21 (1989) 241-248
41. Rowe D.E., Carroll R.H., and Day C.L. Prognostic factor for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. J Am Acad Dermatol 26 (1992) 976-990
42. Williams L.S., Mancuso A.A., and Mendenhall W.M. Perineural spread of cutaneous squamous and basal cell carcinoma: CT and MR detection and its impact on patient management and prognosis. Int J Radiat Oncol Biol Phys 49 4 (2001) 1061-1069
43. Ratner D., Lowe L., Johnson T.M., et al. Perineural spread of basal cell carcinomas treated with Mohs micrographic surgery. Cancer 88 7 (2000) 1605-1613
44. Backous D.D., DeMonte F., El-Naggar A., et al. Craniofacial resection for nonmelanoma skin cancer of the head and neck. Laryngoscope 115 6 (2005) 931-937
45. McCord M.W., Mendenhall W.M., Parsons J.T., et al. Skin cancer of the head and neck with clinical perineural invasion. Int J Radiat Oncol Biol Phys 47 1 (2000) 89-93
46. McCord M.W., Mendenhall W.M., Parsons J.T., et al. Skin cancer of the head and neck with incidental microscopic perineural invasion. Int J Radiat Oncol Biol Phys 43 3 (1999) 591-595
47. Hruza G.J. Mohs micrographic surgery. Otolaryngol Clin North Am 23 5 (1990) 845-864
48. Shriner D.L., McCoy D.K., Goldberg D.J., et al. Mohs micrographic surgery. J Am Acad Dermatol 39 1 (1998) 79-97
49. Khurana V.G., Mentis D.H., O'Brien C.J., et al. Parotid and neck metastases from cutaneous squamous cell carcinoma of the head and neck. Am J Surg 170 5 (1995) 446-450
50. Hong T.S., Kriesel K.J., Hartig G.K., et al. Parotid area lymph node metastases from cutaneous squamous cell carcinoma: implications for diagnosis, treatment, and prognosis. Head Neck 27 10 (2005) 851-856
51. Vauterin T.J., Veness M.J., Morgan G.J., et al. Patterns of lymph node spread of cutaneous squamous cell carcinoma of the head and neck. Head Neck 28 9 (2006) 785-791
52. O'Brien C.J., McNeil E.B., McMahon J.D., et al. Incidence of cervical node involvement in metastatic cutaneous malignancy involving the parotid gland. Head Neck 23 9 (2001) 744-748
53. Veness M.J., Morgan G.J., Palme C.E., et al. Surgery and adjuvant radiotherapy in patients with cutaneous head and neck squamous cell carcinoma metastatic to lymph nodes: combined treatment should be considered best practice. Laryngoscope 115 5 (2005) 870-875
54. Rowe D.E., Carroll R.J., and Day Jr. C.L. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol 26 6 (1992) 976-990 [Review]
55. Bentz B.G., Singh B., Woodruff J., et al. Head and neck soft tissue sarcomas: a multivariate analysis of outcomes. Ann Surg Oncol 11 6 (2004) 619-628
56. Stojadinovic A., Karpoff H.M., Antonescu C.R., et al. Dermatofibrosarcoma protuberans of the head and neck. Ann Surg Oncol 7 9 (2000) 696-704
57. Bowne W.B., Antonescu C.R., Leung D.H., et al. Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution. Cancer 88 12 (2000) 2711-2720
58. Tom W.D., Hybarger C.P., and Rasgon B.M. Dermatofibrosarcoma protuberans of the head and neck: treatment with Mohs surgery using inverted horizontal paraffin sections. Laryngoscope 113 8 (2003) 1289-1293
59. Ratner D., Thomas C.O., Johnson T.M., et al. Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans. Results of a multiinstitutional series with an analysis of the extent of microscopic spread. J Am Acad Dermatol 37 4 (1997) 600-613
60. Prieto V.G., Reed J.A., and Shea C.R. CD34 immunoreactivity distinguishes between scar tissue and residual tumor in re-excisional specimens of dermatofibrosarcoma protuberans. J Cutan Pathol 21 4 (1994) 324-329
61. Abbott J.J., Oliveira A.M., and Nascimento A.G. The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans. Am J Surg Pathol 30 4 (2006) 436-443
62. Mentzel T., Beham A., Katenkamp D., et al. Fibrosarcomatous ("high-grade") dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance. Am J Surg Pathol 22 5 (1998) 576-587
63. Khatri V.P., Galante J.M., Bold R.J., et al. Dermatofibrosarcoma protuberans: reappraisal of wide local excision and impact of inadequate initial treatment. Ann Surg Oncol 10 9 (2003) 1118-1122
64. Simman R., DeFranzo A., Sanger C., et al. Dermatofibrosarcoma protuberans of the face: surgical management. J Craniofac Surg 16 3 (2005) 439-443
65. Ballo M.T., Zagars G.K., Pisters P., et al. The role of radiation therapy in the management of dermatofibrosarcoma protuberans. Int J Radiat Oncol Biol Phys 40 4 (1998) 823-827
66. Suit H., Spiro I., Mankin H.J., et al. Radiation in management of patients with dermatofibrosarcoma protuberans. J Clin Oncol 14 8 (1996) 2365-2369
67. Toker C. Trabecular carcinoma of the skin. Arch Dermatol 105 (1972) 107-110
68. Hodgson N.C. Merkel cell carcinoma: changing incidence trends. J Surg Oncol 89 1 (2005) 1-4
69. Nolan R.C., Chan M.T., and Heenan P.J. A clinicopathologic review of lethal nonmelanoma skin cancers in Western Australia. J Am Acad Dermatol 52 1 (2005) 101-108
70. Eng T.Y., Boersma M.G., Fuller C.D., et al. Treatment of Merkel cell carcinoma. Am J Clin Oncol 27 5 (2004) 510-515
71. Agelli M., and Clegg L.X. Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol 49 5 (2003) 832-841
72. Buell J.F., Trofe J., Hanaway M.J., et al. Immunosuppression and Merkel cell cancer. Transplant Proc 34 5 (2002) 1780-1781
73. Sidhu G.S., Chandra P., and Cassai N.D. Merkel cells, normal and neoplastic: an update. Ultrastruct Pathol 29 3-4 (2005) 287-294 [Review]
74. Koljonen V.S. Merkel cell carcinoma. World J Surg Oncol 4 1 (2006) 7 [electronic publication ahead of print]
75. Sandel IV H.D., Day T., Richardson M.S., et al. Merkel cell carcinoma: does tumor size or depth of invasion correlate with recurrence, metastasis, or patient survival?. Laryngoscope 116 5 (2006) 791-795
76. Boyer J.D., Zitelli J.A., Brodland D.G., et al. Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol 47 6 (2002) 885-892 [Review]
77. Brissett A.E., Olsen K.D., Kasperbauer J.L., et al. Merkel cell carcinoma of the head and neck: a retrospective case series. Head Neck 24 11 (2002) 982-988
78. Sian K.U., Wagner J.D., Sood R., et al. Lymphoscintigraphy with sentinel lymph node biopsy in cutaneous Merkel cell carcinoma. Ann Plast Surg 42 6 (1999) 679-682
79. Gupta S.G., Wang L.C., Penas P.F., et al. Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature. Arch Dermatol 142 6 (2006) 685-690
80. Allen P.J., Bowne W.B., Jaques D.P., et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol 23 10 (2005) 2300-2309
81. Schmalbach C.E., Lowe L., Teknos T.N., et al. Reliability of sentinel lymph node biopsy for regional staging of head and neck Merkel cell carcinoma. Arch Otolaryngol Head Neck Surg 131 7 (2005) 610-614
82. Veness M.J. Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): an overview on management. Australas J Dermatol 47 3 (2006) 160-165
83. Alsaad K.O., Obaidat N.A., and Ghazarian D. Skin adnexal neoplasms-part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol (2006) [electronic publication ahead of print]
84. Obaidat N.A., Alsaad K.O., and Ghazarian D. Skin adnexal neoplasms-part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol (2006) [electronic publication ahead of print]
85. Crowson A.N., Magro C.M., and Mihm M.C. Malignant adnexal neoplasms. Mod Pathol 19 Suppl 2 (2006) S93-S126 [Review]
86. Leibovitch I., Huilgol S.C., Richards S., et al. Periocular microcystic adnexal carcinoma: management and outcome with Mohs' micrographic surgery. Ophthalmologica 220 2 (2006) 109-113
87. Durairaj V.D., Hink E.M., Kahook M.Y., et al. Mucinous eccrine adenocarcinoma of the periocular region. Ophthal Plast Reconstr Surg 22 1 (2006) 30-35
88. Tierney E., Ochoa M.T., Rudkin G., et al. Mohs' micrographic surgery of a proliferating trichilemmal tumor in a young black man. Dermatol Surg 31 3 (2005) 359-363
89. Cowden A., Dans M., Militello G., et al. Eccrine porocarcinoma arising in two African American patients: distinct presentations both treated with Mohs micrographic surgery. Int J Dermatol 45 2 (2006) 146-150
90. Hodgson T.A., Haricharan A.K., Barrett A.W., et al. Microcystic adnexal carcinoma: an unusual cause of swelling and paraesthesia of the lower lip. Oral Oncol 39 2 (2003) 195-198 [Review]
91. Friedman P.M., Friedman R.H., Jiang S.B., et al. Microcystic adnexal carcinoma: collaborative series review and update. J Am Acad Dermatol 41 2 Pt 1 (1999) 225-231 [Review]
92. Snow S., Madjar D.D., Hardy S., et al. Microcystic adnexal carcinoma: report of 13 cases and review of the literature. Dermatol Surg 27 4 (2001) 401-408 [Review]
93. Chu A., and Osguthorpe J.D. Nonmelanoma cutaneous malignancy with regional metastasis. Otolaryngol Head Neck Surg 128 5 (2003) 663-673
94. Lai S.Y., Weinstein G.S., Chalian A.A., et al. Parotidectomy in the treatment of aggressive cutaneous malignancies. Arch Otolaryngol Head Neck Surg 128 5 (2002) 521-526
95. Audet N., Palme C.E., Gullane P.J., et al. Cutaneous metastatic squamous cell carcinoma to the parotid gland: analysis and outcome. Head Neck 26 8 (2004) 727-732
96. Andruchow J.L., Veness M.J., Morgan G.J., et al. Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes. Cancer 106 5 (2006) 1078-1083
97. Palme C., O'Brien C., Veness M., et al. Extent of parotid disease influences outcome in patients with metastatic cutaneous squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 129 (2003) 750-753
98. Yoon M., Chougule P., Dufresne R., et al. Localized carcinoma of the external ear is an unrecognized aggressive disease with a high propensity for local regional recurrence. Am J Surg 164 6 (1992) 574-577 [Review]
99. Choi J.Y., Choi E.C., Lee H.K., et al. Mode of parotid involvement in external auditory canal carcinoma. J Laryngol Otol 117 12 (2003) 951-954
100. Moore B.A., Weber R.S., Prieto V., et al. Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Laryngoscope 115 9 (2005) 1561-1567
101. Ch'ng S., Maitra A., Lea R., et al. Parotid metastasis-an independent prognostic factor for head and neck cutaneous squamous cell carcinoma. J Plast Reconstr Aesthet Surg 59 12 (2006) 1288-1293
102. Barzilai G., Greenberg E., Cohen-Kerem R., et al. Pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck. Otolaryngol Head Neck Surg 132 6 (2005) 852-856
103. Ying Y.L., Johnson J.T., and Myers E.N. Squamous cell carcinoma of the parotid gland. Head Neck 28 7 (2006) 626-632
104. Lee K., McKean M.E., and McGregor I.A. Metastatic patterns of squamous carcinoma in the parotid lymph nodes. Br J Plast Surg 38 1 (1985) 6-10
105. Dona E., Veness M.J., Cakir B., et al. Metastatic cutaneous squamous cell carcinoma to the parotid: the role of surgery and adjuvant radiotherapy to achieve best outcome. ANZ J Surg 73 9 (2003) 692-696
106. Taylor Jr. B.W., Brant T.A., Mendenhall N.P., et al. Carcinoma of the skin metastatic to parotid area lymph nodes. Head Neck 13 5 (1991) 427-433
107. Lindelof B., Sigurgeirsson B., Gabel H., et al. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol 143 3 (2000) 513-519
108. Jensen P., Hansen S., Moller B., et al. Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol 40 2 Pt 1 (1999) 177-186
109. Euvrard S., Kanitakis J., and Claudy A. Skin cancers after organ transplantation. N Engl J Med 348 17 (2003) 1681-1691
110. Berg D., and Otley C.C. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol 47 1 (2002) 1-17 [quiz 18-20]
111. Moloney F.J., Comber H., O'Lorcain P., et al. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol 154 3 (2006) 498-504
112. Stasko T., Brown M.D., Carucci J.A., et al. Guidelines for the management of squamous cell carcinoma in organ transplant recipients. Dermatol Surg 30 4 Pt 2 (2004) 642-650
113. Hoglund P. DNA damage and tumor surveillance: one trigger for two pathways. Sci STKE 2006 317 (2006) pe2 [Review]
114. Harwood C.A., Proby C.M., McGregor J.M., et al. Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series. J Am Acad Dermatol 54 2 (2006) 290-300
115. Bouwes Bavinck J.N., Feltkamp M., Struijk L., et al. Human papillomavirus infection and skin cancer risk in organ transplant recipients. J Investig Dermatol Symp Proc 6 3 (2001) 207-211 [Review]
116. Stockfleth E., Nindl I., Sterry W., et al. Human papillomaviruses in transplant-associated skin cancers. Dermatol Surg 30 4 Pt 2 (2004) 604-609
117. de Graaf Y.G., Basdew V.R., van Zwan-Kralt N., et al. The occurrence of residual or recurrent squamous cell carcinomas in organ transplant recipients after curettage and electrodesiccation. Br J Dermatol 154 3 (2006) 493-497
118. Martinez J.C., Otley C.C., Stasko T., et al. Defining the clinical course of metastatic skin cancer in organ transplant recipients: a multicenter collaborative study. Arch Dermatol 139 3 (2003) 301-306
119. Lindelof B., Jarnvik J., Ternesten-Bratel A., et al. Mortality and clinicopathological features of cutaneous squamous cell carcinoma in organ transplant recipients: a study of the Swedish cohort. Acta Derm Venereol 86 3 (2006) 219-222
120. Smith K.J., Hamza S., and Skelton H. Histologic features in primary cutaneous squamous cell carcinomas in immunocompromised patients focusing on organ transplant patients. Dermatol Surg 30 4 Pt 2 (2004) 634-641
121. Carucci J.A., Martinez J.C., Zeitouni N.C., et al. In-transit metastasis from primary cutaneous squamous cell carcinoma in organ transplant recipients and nonimmunosuppressed patients: clinical characteristics, management, and outcome in a series of 21 patients. Dermatol Surg 30 4 Pt 2 (2004) 651-655
122. De Graaf Y.G., Euvrard S., and Bouwes Bavinck J.N. Systemic and topical retinoids in the management of skin cancer in organ transplant recipients. Dermatol Surg 30 4 Pt 2 (2004) 656-661 [Review]
123. Ulrich C., Busch J.O., Meyer T., et al. Successful treatment of multiple actinic keratoses in organ transplant patients with topical 5% imiquimod: a report of six cases. Br J Dermatol 155 2 (2006) 451-454
124. Martinez J.C., Otley C.C., Okuno S.H., et al. Chemotherapy in the management of advanced cutaneous squamous cell carcinoma in organ transplant recipients: theoretical and practical considerations. Dermatol Surg 30 4 Pt 2 (2004) 679-686 [Review]