Gas bubbles may not be the underlying cause of decompression illness - The at-depth endothelial dysfunction hypothesis

Medical Hypotheses

Volumn 72, Issue 4, 2009, Pages 389-392

  Madden, Leigh A ^a   Laden, Gerard ^b  

^a UNIVERSITY OF HULL   (United Kingdom)

^b Hull and East Riding Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; OXIDIZING AGENT; OXYGEN;

ARTICLE; BLOOD VESSEL INJURY; BREATHING; CELL ACTIVATION; CELL FUNCTION; CIRCULATION; DECOMPRESSION SICKNESS; DEPTH PERCEPTION; DISEASE COURSE; DISEASE EXACERBATION; DIVER; ENDOTHELIAL MICROPARTICLE; ENDOTHELIUM CELL; GAS FLOW; HEMOSTASIS; HUMAN; HYPOTHESIS; INFLAMMATION; ISCHEMIA; LEUKOCYTE AGGREGATION; MEMBRANE MICROPARTICLE; OXIDATION; PHYSICAL ACTIVITY; POPULATION RISK; PRESSURE; PRIORITY JOURNAL; REPERFUSION; RISK FACTOR; SHEAR STRESS; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANTIOXIDANTS; DECOMPRESSION SICKNESS; ENDOTHELIUM, VASCULAR; HUMANS; OXIDATIVE STRESS;

EID: 60449087043     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.11.022     Document Type: Article

References (29)

1. Eckenhoff R.G., Olstad C.S., and Carrod G. Human Dose-Response Relationship for Decompression and Endogenous Bubble Formation. J Appl Physiol 69 3 (1990) 914-918
2. Townsley M.I., Parker J.C., Longenecker G.L., Perry M.L., Pitt R.M., and Taylor A.E. Pulmonary-embolism - analysis of endothelial pore sizes in canine lung. Am J Physiol 255 5 (1988) H1075-H1083
3. DeGorordo A., Vallejo-Manzur F., Chanin K., and Varon J. Diving emergencies. Resuscitation 59 2 (2003) 171-180
4. Eckmann D.M., and Armstead S.C. Influence of endothelial glycocalyx degradation and surfactants on air embolism adhesion. Anesthesiology 105 6 (2006) 1220-1227
5. Montcalm-Smith E., Caviness J., Chen Y., and McCarron R.M. Stress biomarkers in a rat model of decompression sickness. Aviat Space Environ Med 78 2 (2007) 87-93
6. Madden L.A., and Laden G. Endothelial microparticles in vascular disease and as a potential marker of decompression illness. Eur J Underwater Hyperbaric Med 8 1&2 (2007) 6-10
7. Alex J., Laden G., Cale A.R.J., Bennett S., Flowers K., Madden L., et al. Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial. J Thorac Cardiovasc Surg 130 6 (2005) 1623-1630
8. Martin J.D., and Thom S.R. Vascular leukocyte sequestration in decompression sickness and prophylactic hyperbaric oxygen therapy in rats. Aviat Space Environ Med 73 6 (2002) 565-569
9. Thom S.R., Mendiguren I., Hardy K., Bolotin T., Fisher D., Nebolon M., et al. Inhibition of human neutrophil beta(2)-integrin-dependent adherence by hyperbaric O-2. Am J Physiol-Cell Physiol 272 3 (1997) C770-C777
10. Landolfi A., Yang Z.J., Savani F., Camporesi E.M., Faralli F., and Bosco G. Pre-treatment with hyperbaric oxygenation reduces bubble formation and platelet activation. Sport Sci Health 1 (2006) 122-128
11. Homma S, Di Tullio MR, Sacco RL. Patent foramen ovale and ischemic stroke. In: Barnett HJM, Mohr JP, editors. Stroke, 3rd ed. Philadelphia: Churchill Livingstone; 1998. p. 1013-7.
12. Brubakk A.O., Duplancic D., Valic Z., Palada I., Obad A., Bakovic D., et al. A single air dive reduces arterial endothelial function in man. J Physiol London 566 3 (2005) 901-906
13. Bevilacqua M.P., Nelson R.M., Mannori G., Cecconi O., and Endothelial-leukocyte adhesion molecules in human d. Ann Rev Med 45 (1994) 361-378
14. Yusuf-Makagiansar H., Anderson M.E., Yakovleva T.V., Murray J.S., and Siahaan T.J. Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Medicinal Res Rev 22 (2002) 147-167
15. Eggers G.W.N., Paley H.W., Leonard J.J., and Warren J.V. Hemodynamic responses to oxygen breathing in man. J Appl Physiol 17 (1961) 75-79
16. Yogaratnam J.Z., Laden G., Madden L., Guvendik M., Cowen M., Greenman J., et al. Hyperbaric oxygen preconditioning safely improves myocardial function, promotes pulmonary vascular flow, and protects the endothelium from ischemic reperfusion injury. Cardiovasc Revascul Med 8 2 (2007) 148-151
17. Chappell M.A., and Payne S.J. A physiological model of the release of gas bubbles from crevices under decompression. Respir Physiol Neurobiol 153 2 (2006) 166-180
18. Wisloff U., and Brubakk A.O. Aerobic endurance training reduces bubble formation and increases survival in rats exposed to hyperbaric pressure. J Physiol London 537 2 (2001) 607-611
19. Madden L.A., Sandstrom M., Lovell R., and McNaughton L. Inducible heat shock protein 70 and its role in preconditioning and exercise. Amino Acids 34 4 (2008) 511-516
20. Mak S., Egre Z., Tanna G., Colman R., and Newton G.E. Vitamin C prevents hyperoxia-mediated vasoconstriction and impairment of endothelium-dependent vasodilation. Am J Physiol-Heart Circulatory Physiol 282 6 (2002) H2414-H2421
21. Obad A., Palada I., Valic Z., Icancev V., Bakovic D., Wisloff U., et al. The effects of acute oral antioxidants on diving-induced alterations in human cardiovascular function. J Physiol London 578 3 (2007) 859-870
22. Vince RV, McNaughton LR, Taylor L, Midgley AW, Laden G, Madden LA. Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives. Eur J Appl Physiol, in press.
23. Morel O., Jessel L., Hugel B., Douchet M.P., Zupan Z., Chauvin M., et al. Protective effects of Vitamin C on endothelium damage and platelet activation during myocardial infarction in patients with sustained generation of circulating microparticles. J Thromb Haem 1 1 (2003) 171-177
24. Diaz M.N., Frei B., Vita J.A., and Keaney J.F. Mechanisms of disease - Antioxidants and atherosclerotic heart disease. New Engl J Med 337 6 (1997) 408-416
25. Langlois M., Duprez D., Delanghe J., De Buyzere M., and Clement D.L. Serum Vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation 103 14 (2001) 1863-1868
26. Gokce N., Keaney J.F., Frei B., Holbrook M., Olesiak M., Zachariah B.J., et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 99 25 (1999) 3234-3240
27. Levine G.N., Frei B., Koulouris S.N., Gerhard M.D., Keaney J.F., and Vita J.A. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 93 6 (1996) 1107-1113
28. Steer P., Milligard J., Basu S., Lithell H., Vessby B., Bernce C., et al. Vitamin C, diclophenac, and l-arginine protect endothelium-dependent vasodilation against elevated circulating fatty acid levels in humans. Atherosclerosis 168 1 (2003) 65-72
29. Taddei S., Virdis A., Ghiadoni L., Maganga A., and Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97 22 (1998) 2222-2229