Escitalopram: A unique mechanism of action

International Journal of Psychiatry in Clinical Practice

Volumn 8, Issue SUPPL. 1, 2004, Pages 11-13

  Bræstrup, Claus ^a   Sanchez, Connie ^a  

^a H LUNDBECK A S   (Denmark)

Author keywords

Antidepression; Citalopram; Depression; Enantiomers; Escitalopram; R citalopram; Serotonin; SSRI; Stereochemistry; Transporter

Indexed keywords

CITALOPRAM; ESCITALOPRAM; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

ALLOSTERISM; CONFERENCE PAPER; DEPRESSION; DOSE RESPONSE; DRUG BINDING SITE; DRUG MECHANISM; FRONTAL CORTEX; HUMAN; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE; STRESS;

EID: 6044231902     PISSN: 13651501     EISSN: None     Source Type: Journal    
DOI: 10.1080/13651500410005496     Document Type: Conference Paper

References (7)

1. Montgomery SA, Loft H, Sánchez C et al (2001) Escitalopram (S-enantiomer of citalopram): clinical efficacy and onset of action predicted from a rat model. Pharmacol Toxicol 88: 282-6.
2. Sanchez C, Gruca P, Papp M (2003) R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model. Behav Pharmacol 14: 465-70.
3. Mørk A, Kreilgaard M, Sánchez C (2003) The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats. Neuropharmacology 45: 167-73.
4. Owens MJ, Knight DL, Nemeroff CB (2001) Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50: 345-50.
5. 3H] citalopram binding to the 5-HT transporter from brain and platelets. Eur J Pharmacol 206: 243-50.
6. Chen F, Larsen MB, Sánchez C, Wiborg O (2003) The S-enantiomer of citalopram increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Poster presented at the 16th European College of Neuropsychopharmacology (ECNP), 20-24 September 2003, Prague, Czech Republic.
7. Sanchez C, Bøgesø K, Ebert B et al (2004) Escitalopram versus citalopram: the surprising role of the R-enantiomer. Psychopharmacol 174: 163-76.