Antibody titers predict clinical features of autoimmune autonomic ganglionopathy

Autonomic Neuroscience: Basic and Clinical

Volumn 146, Issue 1-2, 2009, Pages 8-12

  Gibbons, Christopher H ^a   Freeman, Roy ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Autoimmune autonomic ganglionopathy; Autonomic failure; Autonomic testing

Indexed keywords

IMMUNOGLOBULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NICOTINIC RECEPTOR; PREDNISONE;

ADULT; ANHIDROSIS; ANTIBODY TITER; ARTICLE; AUTOIMMUNE AUTONOMIC GANGLIONOPATHY; AUTOIMMUNE DISEASE; AUTONOMIC DYSFUNCTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONSTIPATION; EXPIRATORY FLOW; FEMALE; HUMAN; MALE; ORTHOSTATIC HYPOTENSION; PEAK INSPIRATORY FLOW; PRIORITY JOURNAL; PUPIL REFLEX; SJOEGREN SYNDROME; STANDING; SYSTOLIC BLOOD PRESSURE; URINARY DYSFUNCTION; VALSALVA MANEUVER;

ADULT; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CONSTIPATION; DISEASE PROGRESSION; FEMALE; GANGLIA, AUTONOMIC; HUMANS; HYPOHIDROSIS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; PHENOTYPE; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; PREDNISONE; PRIMARY DYSAUTONOMIAS; PUPIL DISORDERS; RECEPTORS, NICOTINIC; SHY-DRAGER SYNDROME; SJOGREN'S SYNDROME; URINATION DISORDERS;

EID: 60349122757     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2008.11.013     Document Type: Article

References (14)

1. Gibbons C., and Freeman R. The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol. Clin. 22 (2004) 683-702 vii
2. Gibbons C.H., Vernino S.A., Kaufmann H., and Freeman R. L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology 65 (2005) 1104-1106
3. Gibbons C.H., Vernino S.A., and Freeman R. Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch. Neurol. 65 (2008) 213-217
4. Goldstein D.S., Holmes C., Dendi R., Li S.T., Brentzel S., and Vernino S. Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor. Clin. Auton. Res. 12 (2002) 281-285
5. Klein C.M., Vernino S., Lennon V.A., Sandroni P., Fealey R.D., Benrud-Larson L., Sletten D., and Low P.A. The spectrum of autoimmune autonomic neuropathies. Ann. Neurol. 53 (2003) 752-758
6. Lennon V.A., Ermilov L.G., Szurszewski J.H., and Vernino S. Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease. J. Clin. Invest. 111 (2003) 907-913
7. Low P.A. Testing the autonomic nervous system. Semin. Neurol. 23 (2003) 407-421
8. Rovit R.L. Autonomic failure: observations of a physician-patient. Clin. Auton. Res. 17 (2007) 234-237
9. Sandroni P., Vernino S., Klein C.M., Lennon V.A., Benrud-Larson L., Sletten D., and Low P.A. Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody. Arch. Neurol. 61 (2004) 44-48
10. Vernino S., Low P.A., Fealey R.D., Stewart J.D., Farrugia G., and Lennon V.A. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N. Engl. J. Med. 343 (2000) 847-855
11. Vernino S., Ermilov L.G., Sha L., Szurszewski J.H., Low P.A., and Lennon V.A. Passive transfer of autoimmune autonomic neuropathy to mice. J. Neurosci. 24 (2004) 7037-7042
12. Vernino S., Lindstrom J., Hopkins S., Wang Z., and Low P.A. Characterization of ganglionic acetylcholine receptor autoantibodies. J. Neuroimmunol. 197 (2008) 63-69
13. Wang Z., Low P.A., Jordan J., Freeman R., Gibbons C.H., Schroeder C., Sandroni P., and Vernino S. Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current. Neurology 68 (2007) 1917-1921
14. Young R.R., Asbury A.K., Corbett J.L., and Adams R.D. Pure pan-dysautonomia with recovery. Brain 98 (1975) 613-636