Cancer screenings, diagnostic technology evolution, and cancer control

Methods in Molecular Biology

Volumn 471, Issue , 2009, Pages 107-136

  Stracci, Fabrizio ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Cancer control; Diagnostic test; Evaluation; Overdiagnosis; Public health; Screening

Indexed keywords

CANCER DIAGNOSIS; FEMALE; HUMAN; MALE; MASS SCREENING; METHODOLOGY; NEOPLASM; REVIEW; STANDARD;

EARLY DETECTION OF CANCER; FEMALE; HUMANS; MALE; MASS SCREENING; NEOPLASMS;

EID: 60349116491     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-416-2_6     Document Type: Review

References (132)

1. Kaposi, M. (1872) Idiopathisches multiples Pigmentsarkom Der Haut. Arch Dermatol Syph 3, 265-273.
2. Iscovich, J., Boffetta, P., Franceschi, S., et al. (2000) Classic Kaposi sarcoma: epidemiology and risk factors. Cancer 88, 500-517.
3. Cohen, A., Wolf, D. G., Guttman-Yassky, E., et al. (2005) Kaposi's sarcoma-associated herpesvirus: clinical, diagnostic, and epidemiological aspects. Crit Rev Cl Lab Sci 42, 101-153.
4. Dourmishev, L. A., Dourmishev, A. L., Palmeri, D., et al. (2003) Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev 67, 175-212.
5. Cook-Mozaffari, P., Newton, R., Beral, V., et al. (1998) The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic. Br J Cancer 78, 1521-1528.
6. Sitas, F., Newton, R. (2001) Kaposi's sarcoma in South Africa. J Natl Cancer Inst Monogr 1-4.
7. Sissolak, G., Mayaud, P. (2005) AIDS-related Kaposi's sarcoma: epidemiological, diagnostic, treatment and control aspects in sub-Saharan Africa. Trop Med Int Health 10, 981-992.
8. Zmonarski, S. C., Boratynska, M., Puziewicz-Zmonarska, A., et al. (2005) Kaposi's sarcoma in renal transplant recipients. Ann Transplant 10, 59-65.
9. Marcelin, A. G., Calvez, V., Dussaix, E. (2007) KSHV after an organ transplant: should we screen? Curr Top Microbiol Immunol 312, 245-262.
10. Goedert, J. J. (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 27, 390-401.
11. Cheung, T. W. (2004) AIDS-related cancer in the era of highly active antiretroviral therapy (HAART): a model of the interplay of the immune system, virus, and cancer. "On the offensive - the Trojan Horse is being destroyed" - Part A: Kaposi's sarcoma. Cancer Invest 22, 774-786.
12. Bower, M., Palmieri, C., Dhillon, T. (2006) AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy. Curr Opin Infect Dis 19, 14-19.
13. Cheung, M. C., Pantanowitz, L., Dezube, B. J. (2005) AIDS-related malignancies: emerging challenges in the era of highly active antiretroviral therapy. Oncologist 10, 412-426.
14. Beral, V., Peterman, T. A., Berkelman, R. L., et al. (1990) Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335, 123-128.
15. Archibald, C. P., Schechter, M. T., Le, T. N., et al. (1992) Evidence for a sexually transmitted cofactor for AIDS-related Kaposi's sarcoma in a cohort of homosexual men. Epidemiology 3, 203-209.
16. Vogel, J., Hinrichs, S. H., Reynolds, R. K., et al. (1988) The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice. Nature 335, 606-611.
17. Ensoli, B., Salahuddin, S. Z., Gallo, R. C. (1989) AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis. Cancer Cells 1, 93-96.
18. Chang, Y., Cesarman, E., Pessin, M. S., et al. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869.
19. Russo, J. J., Bohenzky, R. A., Chien, M. C., et al. (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 93, 14862-14867.
20. Moore, P. S., Chang, Y. (1995) Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med 332, 1181-1185.
21. Cesarman, E., Chang, Y., Moore, P. S., et al. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332, 1186-1191.
22. Soulier, J., Grollet, L., Oksenhendler, E., et al. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86, 1276-1280.
23. Codish, S., Abu-Shakra, M., Ariad, S., et al. (2000) Manifestations of three HHV-8-related diseases in an HIV-negative patient: immunoblastic variant multicentric Castleman's disease, primary effusion lymphoma, and Kaposi's sarcoma. Am J Hematol 65, 310-314.
24. Ascoli, V., Signoretti, S., Onetti-Muda, A., et al. (2001) Primary effusion lymphoma in HIV-infected patients with multicentric Castleman's disease. J Pathol 193, 200-209.
25. Sukpanichnant, S., Sivayathorn, A., Visudhiphan, S., et al. (2002) Multicentric Castleman's disease, non-Hodgkin's lymphoma, and Kaposi's sarcoma: a rare simultaneous occurrence. Asian Pac J Allergy Immunol 20, 127-133.
26. Kasolo, F. C., Mpabalwani, E., Gompels, U. A. (1997) Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. J Gen Virol 78(Pt 4), 847-855.
27. Sarmati, L. (2004) HHV-8 infection in African children. Herpes 11, 50-53.
28. Andreoni, M., El-Sawaf, G., Rezza, G., et al. (1999) High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: evidence of nonsexual transmission. J Natl Cancer Inst 91, 465-469.
29. Wang, Q. J., Jenkins, F. J., Jacobson, L. P., et al. (2001) Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins. Blood 97, 2366-2373.
30. Luppi, M., Barozzi, P., Schulz, T. F., et al. (2000) Bone marrow failure associated with human herpesvirus 8 infection after transplantation. N Engl J Med 343, 1378-1385.
31. Sarid, R., Pizov, G., Rubinger, D., et al. (2001) Detection of human herpesvirus-8 DNA in kidney allografts prior to the development of Kaposi's sarcoma. Clin Infect Dis 32, 1502-1505.
32. Marcelin, A. G., Roque-Afonso, A. M., Hurtova, M., et al. (2004) Fatal disseminated Kaposi's sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients. Liver Transpl 10, 295-300.
33. Renne, R., Zhong, W., Herndier, B., et al. (1996) Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 2, 342-346.
34. Sarid, R., Flore, O., Bohenzky, R. A., et al. (1998) Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J Virol 72, 1005-1012.
35. Krishnan, H. H., Naranatt, P. P., Smith, M. S., et al. (2004) Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78, 3601-3620.
36. Grundhoff, A., Ganem, D. (2004) Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest 113, 124-136.
37. Chen, J., Ueda, K., Sakakibara, S., et al. (2001) Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc Natl Acad Sci USA 98, 4119-4124.
38. Chang, J., Renne, R., Dittmer, D., et al. (2000) Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology 266, 17-25.
39. Davis, D. A., Rinderknecht, A. S., Zoeteweij, J. P., et al. (2001) Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood 97, 3244-3250.
40. Deutsch, E., Cohen, A., Kazimirsky, G., et al. (2004) Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol 78, 10187-10192.
41. Sgarbanti, M., Arguello, M., tenOever, B. R., et al. (2004) A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions. Oncogene 23, 5770-5780.
42. McAllister, S. C., Hansen, S. G., Messaoudi, I., et al. (2005) Increased efficiency of phorbol ester-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus during S phase. J Virol 79, 2626-2630.
43. Brown, H. J., McBride, W. H., Zack, J. A., et al. (2005) Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus. Antivir Ther 10, 745-751.
44. Chang, M., Brown, H. J., Collado-Hidalgo, A., et al. (2005) Beta-adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J Virol 79, 13538-13547.
45. Morris, T. L., Arnold, R. R., Webster-Cyriaque, J. (2007) Signaling cascades triggered by bacterial metabolic end-products during KSHV reactivation. J Virol 81, 6032-6042.
46. Staudt, M. R., Dittmer, D. P. (2007) The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Curr Top Microbiol Immunol 312, 71-100.
47. Whitby, D., Marshall, V. A., Bagni, R. K., et al. (2007) Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions. Int J Cancer 120, 321-328.
48. Aoki, Y., Tosato, G. (2007) Interactions between HIV-1 Tat and KSHV. Curr Top Microbiol Immunol 312, 309-326.
49. Parravicini, C., Olsen, S. J., Capra, M., et al. (1997) Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Blood 90, 2826-2829.
50. Campbell, T. B., Borok, M., Gwanzura, L., et al. (2000) Relationship of human herpesvirus 8 peripheral blood virus load and Kaposi's sarcoma clinical stage. AIDS 14, 2109-2116.
51. Quinlivan, E. B., Zhang, C., Stewart, P. W., et al. (2002) Elevated virus loads of Kaposi's sarcoma-associated human herpesvirus 8 predict Kaposi's sarcoma disease progression, but elevated levels of human immunodeficiency virus type 1 do not. J Infect Dis 185, 1736-1744.
52. Tedeschi, R., Enbom, M., Bidoli, E., et al. (2001) Viral load of human herpesvirus 8 in peripheral blood of human immunodeficiency virus-infected patients with Kaposi's sarcoma. J Clin Microbiol 39, 4269-4273.
53. Polstra, A. M., Cornelissen, M., Goudsmit, J., et al. (2004) Retrospective, longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis. J Med Virol 74, 390-396.
54. Pellet, C., Chevret, S., Frances, C., et al. (2002) Prognostic value of quantitative Kaposi sarcoma-associated herpesvirus load in posttransplantation Kaposi sarcoma. J Infect Dis 186, 110-113.
55. Gessain, A., Duprez, R. (2005) Spindle cells and their role in Kaposi's sarcoma. Int J Biochem Cell Biol 37, 2457-2465.
56. Montaner, S., Sodhi, A., Molinolo, A., et al. (2003) Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3, 23-36.
57. Guo, H. G., Sadowska, M., Reid, W., et al. (2003) Kaposi's sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. J Virol 77, 2631-2639.
58. Grisotto, M. G., Garin, A., Martin, A. P., et al. (2006) The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest 116, 1264-1273.
59. Mutlu, A. D., Cavallin, L. E., Vincent, L., et al. (2007) In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell 11, 245-258.
60. Brown, E. E., Whitby, D., Vitale, F., et al. (2006) Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma. Cancer 107, 2282-2290.
61. Hengge, U. R., Ruzicka, T., Tyring, S. K., et al. (2002) Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphoma. Lancet Infect Dis 2, 344-352.
62. Cesarman, E., Mesri, E. A. (2007) Kaposi sarcoma-associated herpesvirus and other viruses in human lymphomagenesis. Curr Top Microbiol Immunol 312, 263-287.
63. Casper, C. (2005) The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol 129, 3-17.
64. Whitby, D., Howard, M. R., Tenant-Flowers, M., et al. (1995) Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 346, 799-802.
65. Widmer, I. C., Erb, P., Grob, H., et al. (2006) Human herpesvirus 8 oral shedding in HIV-infected men with and without Kaposi sarcoma. J Acquir Immune Defic Syndr 42, 420-425.
66. Boldogh, I., Szaniszlo, P., Bresnahan, W. A., et al. (1996) Kaposi's sarcoma herpesvirus-like DNA sequences in the saliva of individuals infected with human immunodeficiency virus. Clin Infect Dis 23, 406-407.
67. Blackbourn, D. J., Lennette, E. T., Ambroziak, J., et al. (1998) Human herpesvirus 8 detection in nasal secretions and saliva. J Infect Dis 177, 213-216.
68. Pauk, J., Huang, M. L., Brodie, S. J., et al. (2000) Mucosal shedding of human herpesvirus 8 in men. N Engl J Med 343, 1369-1377.
69. Pellett, P. E., Spira, T. J., Bagasra, O., et al. (1999) Multicenter comparison of PCR assays for detection of human herpesvirus 8 DNA in semen. J Clin Microbiol 37, 1298-1301.
70. Diamond, C., Brodie, S. J., Krieger, J. N., et al. (1998) Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma. J Virol 72, 6223-6227.
71. Cerimele, F., Curreli, F., Ely, S., et al. (2001) Kaposi's sarcoma-associated herpesvirus can productively infect primary human keratinocytes and alter their growth properties. J Virol 75, 2435-2443.
72. Akula, S. M., Wang, F. Z., Vieira, J., et al. (2001) Human herpesvirus 8 interaction with target cells involves heparan sulfate. Virology 282, 245-255.
73. Krishnan, H. H., Sharma-Walia, N., Zeng, L., et al. (2005) Envelope glycoprotein gB of Kaposi's sarcoma-associated herpesvirus is essential for egress from infected cells. J Virol 79, 10952-10967.
74. Martin, J. N., Ganem, D. E., Osmond, D. H., et al. (1998) Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 338, 948-954.
75. Blackbourn, D. J., Osmond, D., Levy, J. A., et al. (1999) Increased human herpesvirus 8 seroprevalence in young homosexual men who have multiple sex contacts with different partners. J Infect Dis 179, 237-239.
76. Grulich, A. E., Kaldor, J. M., Hendry, O., et al. (1997) Risk of Kaposi's sarcoma and oroanal sexual contact. Am J Epidemiol 145, 673-679.
77. Smith, N. A., Sabin, C. A., Gopal, R., et al. (1999) Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex. J Infect Dis 180, 600-606.
78. Osmond, D. H., Buchbinder, S., Cheng, A., et al. (2002) Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. JAMA 287, 221-225.
79. Mayama, S., Cuevas ,L. E., Sheldon, J., et al. (1998) Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 77, 817-820.
80. Gessain, A., Mauclere, P., van Beveren, M., et al. (1999) Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa. Int J Cancer 81, 189-192.
81. Bourboulia, D., Whitby, D., Boshoff, C., et al. (1998) Serologic evidence for mother-to-child transmission of Kaposi sarcoma- associated herpesvirus infection [letter]. JAMA 280, 31-32.
82. Plancoulaine, S., Abel, L., van Beveren, M., et al. (2000) Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population. Lancet 356, 1062-1065.
83. Sarmati, L., Carlo, T., Rossella, S., et al. (2004) Human herpesvirus-8 infection in pregnancy and labor: lack of evidence of vertical transmission. J Med Virol 72, 462-466.
84. Angeloni, A., Heston, L., Uccini, S., et al. (1998) High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia. J Infect Dis 177, 1715-1718.
85. Guttman-Yassky, E., Kra-Oz, Z., Dubnov, J., et al. (2005) Infection with Kaposi's sarcoma-associated herpesvirus among families of patients with classic Kaposi's sarcoma. Arch Dermatol 141, 1429-1434.
86. Davidovici, B., Karakis, I., Bourboulia, D., et al. (2001) Seroepidemiology and molecular epidemiology of Kaposi's Sarcoma-associated herpesvirus among Jewish population groups in Israel. J Natl Cancer Inst 93, 194-202.
87. Plancoulaine, S., Abel, L., Tregouet, D., et al. (2004) Respective roles of serological status and blood specific antihuman herpesvirus 8 antibody levels in human herpesvirus 8 intra-familial transmission in a highly endemic area. Cancer Res 64, 8782-8787.
88. Mbulaiteye, S. M., Biggar, R. J., Bakaki, P. M., et al. (2003) Human herpesvirus 8 infection and transfusion history in children with sickle-cell disease in Uganda. J Natl Cancer Inst 95, 1330-1335.
89. Hladik, W., Dollard, S. C., Mermin, J., et al. (2006) Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med 355, 1331-1338.
90. Barozzi, P., Luppi, M., Facchetti, F., et al. (2003) Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nat Med 9, 554-561.
91. Parkin, D. M., Whelan, S. L., Ferlay, J., et al. (2003) Cancer Incidence in Five Continents, Vol. VIII. IARC Scientific Publications, Lyon, France.
92. Gao, S. J., Kingsley, L., Li, M., et al. (1996) KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 2, 925-928.
93. Gao, S. J., Kingsley, L., Hoover, D. R., et al. (1996) Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med 335, 233-241.
94. Kedes, D. H., Operskalski, E., Busch, M., et al. (1996) The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 2, 918-924.
95. Simpson, G. R., Schulz, T. F., Whitby, D., et al. (1996) Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 348, 1133-1138.
96. Laney, A. S., Peters, J. S., Manzi, S. M., et al. (2006) Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J Clin Microbiol 44, 3734-3741.
97. Dukers, N. H., Rezza, G. (2003) Human herpesvirus 8 epidemiology: what we do and do not know. AIDS 17, 1717-1730.
98. Mohanna, S., Maco, V., Bravo, F., et al. (2005) Epidemiology and clinical characteristics of classic Kaposi's sarcoma, seroprevalence, and variants of human herpesvirus 8 in South America: a critical review of an old disease. Int J Infect Dis 9, 239-250.
99. Dedicoat, M., Newton, R. (2003) Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma. Br J Cancer 88, 1-3.
100. Plancoulaine, S., Gessain, A., van Beveren, M., et al. (2003) Evidence for a recessive major gene predisposing to human herpesvirus 8 (HHV-8) infection in a population in which HHV-8 is endemic. J Infect Dis 187, 1944-1950.
101. Ariyoshi, K., Schim, V. D. L., Cook, P., et al. (1998) Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. J Hum Virol 1, 193-199.
102. He, F., Wang, X., He, B., et al. (2007) Human herpesvirus 8: serovprevalence and correlates in tumor patients from Xinjiang, China. J Med Virol 79, 161-166.
103. Biggar, R. J., Whitby, D., Marshall, V., et al. (2000) Human herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype. J Infect Dis 181, 1562-1568.
104. Grossman, Z., Iscovich, J., Schwartz, F., et al. (2002) Absence of Kaposi sarcoma among Ethiopian immigrants to Israel despite high seroprevalence of human herpesvirus 8. Mayo Clin Proc 77, 905-909.
105. Cottoni, E., Masia, I. M., Masala, M. V., et al. (1996) Familial Kaposi's sarcoma: case reports and review of the literature. Acta Derm Venereol 76, 59-61.
106. Guttman-Yassky, E., Cohen, A., Kra-Oz, Z., et al. (2004) Familial clustering of classic Kaposi sarcoma. J Infect Dis 189, 2023-2026.
107. Hayward, G. S., Zong, J. C. (2007) Modern evolutionary history of the human KSHV genome. Curr Top Microbiol Immunol 312, 1-42.
108. Sarid, R., Olsen, S. J., Moore, P. S. (1999) Kaposi's sarcoma-associated herpesvirus epidemiology, virology, and molecular biology. Adv Virus Res 52, 139-232.
109. Vitale, F., Briffa, D. V., Whitby, D., et al. (2001) Kaposi's sarcoma herpes virus and Kaposi's sarcoma in the elderly populations of 3 Mediterranean islands. Int J Cancer 91, 588-591.
110. Woodle, E. S., Hanaway, M., Buell, J., et al. (2001) Kaposi sarcoma: an analysis of the US and international experiences from the Israel Penn International Transplant Tumor Registry. Transplant Proc 33, 3660-3661.
111. Renwick, N., Halaby, T., Weverling, G. J., et al. (1998) Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. AIDS 12, 2481-2488.
112. Dorak, M. T., Yee, L. J., Tang, J., et al. (2005) HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. J Med Virol 76, 302-310.
113. Gaya, A., Esteve, A., Casabona, J., et al. (2004) Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients. AIDS 18, 199-204.
114. Cottoni, F., Masala, M. V., Santarelli, R., et al. (2004) Susceptibility to human herpesvirus-8 infection in a healthy population from Sardinia is not directly correlated with the expression of HLA-DR alleles. Br J Dermatol 151, 247-249.
115. Foster, C. B., Lehrnbecher, T., Samuels, S., et al. (2000) An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. Blood 96, 2562-2567.
116. Lehrnbecher, T. L., Foster, C. B., Zhu, S., et al. (2000) Variant genotypes of FcgammaRIIIA influence the development of Kaposi's sarcoma in HIV-infected men. Blood 95, 2386-2390.
117. Brown, E. E., Fallin, D., Ruczinski, I., et al. (2006) Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity. Cancer Epidemiol Biomarkers Prev 15, 926-934.
118. Simonart, T. (2006) Role of environmental factors in the pathogenesis of classic and African-endemic Kaposi sarcoma. Cancer Lett 244, 1-7.
119. Montella, M., Serraino, D., Crispo, A., et al. (2000) Is volcanic soil a cofactor for classic Kaposi's sarcoma? Eur J Epidemiol 16, 1185-1186.
120. Nawar, E., Mbulaiteye, S. M., Gallant, J. E., et al. (2005) Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDS. Int J Cancer 115, 296-300.
121. Goedert, J. J., Vitale, F., Lauria, C., et al. (2002) Risk factors for classical Kaposi's sarcoma. J Natl Cancer Inst 94, 1712-1718.
122. Guttman-Yassky, E., Dubnov, J., Kra-Oz, Z., et al. (2006) Classic Kaposi sarcoma. Which KSHV-seropositive individuals are at risk? Cancer 106, 413-419.
123. Pfeffer, S., Sewer, A., Lagos-Quintana, M., et al. (2005) Identification of microRNAs of the herpesvirus family. Nat Methods 2, 269-276.
124. Cai, X., Lu, S., Zhang, Z., et al. (2005) Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci USA 102, 5570-5575.
125. Samols, M. A., Hu, J., Skalsky, R. L., et al. (2005) Cloning and identification of a micro-RNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J Virol 79, 9301-9305.
126. Grundhoff, A., Sullivan, C. S., Ganem, D. (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12, 733-750.
127. Moore, P. S., Chang, Y. (2003) Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin? Annu Rev Microbiol 57, 609-639.
128. Schulz, T. F. (2006) The pleiotropic effects of Kaposi's sarcoma herpesvirus. J Pathol 208, 187-198.
129. Jarviluoma, A., Ojala, P. M. (2006) Cell signaling pathways engaged by KSHV. Biochim Biophys Acta 1766, 140-158.
130. Rezaee, S. A., Cunningham, C., Davison, A. J., et al. (2006) Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J Gen Virol 87, 1781-1804.
131. Sodhi, A., Montaner, S., Gutkind, J. S. (2004) Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? FASEB J 18, 422-427.
132. Boshoff, C. (2003) Kaposi virus scores cancer coup. Nat Med 9, 261-262.