Peripheral olfactory system for clinical and basic psychiatry: A promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia

American Journal of Psychiatry

Volumn 166, Issue 2, 2009, Pages 137-139

  Sawa, Akira ^a   Cascella, Nicola G ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYCLIC AMP;

DISEASE ASSOCIATION; DISEASE MARKER; EDITORIAL; GENETIC SUSCEPTIBILITY; HUMAN; HYPOSMIA; OLFACTORY DISCRIMINATION; OLFACTORY EPITHELIUM; OLFACTORY SYSTEM; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

BIOLOGICAL MARKERS; CYCLIC AMP; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; OLFACTION DISORDERS; OLFACTORY BULB; OLFACTORY MUCOSA; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SENSORY THRESHOLDS; SIGNAL TRANSDUCTION;

EID: 60349114748     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2008.08111702     Document Type: Editorial

References (15)

1. Cascella NG, Takaki M, Lin S, Sawa A: Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research. J Neurochem 2007; 102:587-594
2. Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL: Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 1999; 21:325-340
3. Brewer WJ, Wood SJ, McGorry PD, Francey SM, Phillips LJ, Yung AR, Anderson V, Copolov DL, Singh B, Velakoulis D, Pantelis C: Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia. Am J Psychiatry 2003: 160:1790-1794
4. Kopala LC, Good KP, Morrison K, Bassett AS, Alda M, Honer WG: Impaired olfactory identification in relatives of patients with familial schizophrenia. Am J Psychiatry 2001: 158:1286-1290
5. Roalf DR, Turetsky BI, Owzar K, Balderston CC, Johnson SC, Brensinger CM, Gur RE, Siegel SJ, Moberg PJ, Unirhinal olfactory function in schizophrenia patients and first-degree relatives. J Neuropsychiatry Clin Neurosci 2006; 18:389-396
6. Arnold SE, Han LY, Moberg PJ, Turetsky BI, Gur RE, Trojanowski JQ, Hahn CG: Dysregulation of olfactory receptor neuron lineage of schizophrenia. Arch Gen Psychiatry 2001; 58: 829-835
7. Turetsky BI, Moberg PJ: An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia. Am J Psychiatry 2009; 166:226-233
8. Coronas V, Feron F, Hen R, Sicard G, Jourdan F, Moyse E: In vitro induction of apoptosis or differentiation by dopamine in an immortalized olfactory neuronal cell line. J Neurochem 1997; 69:1870-1881
9. Feron F, Perry C, Hirning MH, Mcgrath J, Mackay-Sim A: Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia. Schizophr Res 1999; 40: 211-218
10. Borgmann-Winter KE, Rawson NE, Wang HY, Wang H, Macdonald ML, Ozdener MH, Yee KK, Gomez G, Xu J, Bryant B, Adamek G, Mirza N, Pribitkin E, Hanh CG: Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics. Neuroscience 2008 (E-Pub ahead of print)
11. Sawa A, Wiegand GW, Cooper J, Margolis RL, Sharp AH, Lawler JF Jr, Greenamycre JT, Snyder SH, Ross CA: Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial dopolarization. Nat Med 1999; 5:1194-1198
12. Ishizuka K, Paek M, Kamiya A, Sawa A: A review of Disrupted-In- Schizophrenia-1 (DISC1): Neurodevelopment, cognition, and mental conditions. Biol Psychiatry 2006: 59:1189-1197
13. Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK: The DICS locus in psychiatric illness. Mol Psychiatry 2008; 13:36-64
14. Minoretti P, Politi P, Coen E, Di Vito C, Bertona M, Bianchi M, Emanuele E: The T393C polymorphism of the GNAS1 gene is associated with deficit schizophrenia in an Italian population sample. Neurosci Lett 2006: 397:159-163
15. Malaspina D, Coleman E, Goetz RR, Harkavy-Friedman J, Corcoran E, Amador X, Yale S, Gorman JM, Odor identification, eye tracking and deficit syndrome schizophrenia. Biol Psychiatry 2002; 51:809-815