Serum Fetuin A in Hemodialysis: A Link Between Derangement of Calcium-Phosphorus Homeostasis and Progression of Atherosclerosis?

American Journal of Kidney Diseases

Volumn 53, Issue 3, 2009, Pages 467-474

  Pertosa, Giovanni ^a   Simone, Simona ^a   Ciccone, Marco ^a   Porreca, Silvia ^a   Zaza, Gianluigi ^a   Dalfino, Giuseppe ^a   Memoli, Bruno ^b   Procino, Alfredo ^b   Bonomini, Mario ^c   Sirolli, Vittorio ^c   Castellano, Giuseppe ^a   Gesualdo, Loreto ^d   Ktena, Maria ^d   Schena, Francesco Paolo ^a   Grandaliano, Giuseppe ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d UNIVERSITY OF FOGGIA   (Italy)

Author keywords

calcium phosphorus; Fetuin A; hemodialysis; intima media thickness

Indexed keywords

C REACTIVE PROTEIN; CALCIUM; FETUIN A; PHOSPHORUS;

ADULT; AGED; ANTHROPOMETRY; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BLOOD LEVEL; CALCIFICATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; COHORT ANALYSIS; DISEASE COURSE; DOWN REGULATION; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HOMEOSTASIS; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OUTCOME ASSESSMENT; PATIENT SELECTION; PROPORTIONAL HAZARDS MODEL; TREATMENT OUTCOME;

AGED; ALPHA-FETOPROTEINS; ATHEROSCLEROSIS; CALCIUM; CARDIOVASCULAR DISEASES; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HOMEOSTASIS; HUMANS; MALE; MIDDLE AGED; PHOSPHORUS; RENAL DIALYSIS;

EID: 60349108344     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2008.10.046     Document Type: Article

References (27)

1. Foley R.N., Parfrey P.S., and Sarak M.J. Clinical epidemiology of cardiovascular disease in chronic renal failure. Am J Kidney Dis 32 suppl 5 (1998) S112-S119
2. London G.M. Cardiovascular calcifications in uremic patients: Clinical impact on cardiovascular function. J Am Soc Nephrol 14 suppl 4 (2003) S305-S309
3. Rost N.S., Wolf P.A., Kase C.S., et al. Plasma concentration of CRP and risk of ischemic stroke and transient ischemic attack: The Framingham Study. Stroke 32 (2001) 2575-2579
4. Albert C., Ma J., Rifai N., et al. Prospective study of CRP, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 105 (2002) 2574-2576
5. Moe S.M., Reslerova M., Ketteler M., et al. Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 67 (2005) 2295-2304
6. Ketteler M., Bongartz P., Westenfeld R., et al. Association of low fetuin-A concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study. Lancet 361 (2003) 827-833
7. Hermans M.M.H., Brandenburg V., Ketteler M., et al. Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int 72 (2007) 202-207
8. Heiss A., DuChesne A., Denecke B., et al. Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem 278 (2003) 13333-13341
9. de Groot E., van Leuven S.I., Duivenvoorden R., et al. Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis. Nat Clin Pract Cardiovasc Med 5 (2008) 280-288
10. O'Leary D.H., Polak J.F., Kronmal R.A., et al. Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. Stroke 23 (1992) 1752-1760
11. Zoccali C., Benedetto F.A., Maas R., et al. Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol 13 (2002) 490-496
12. Nishizawa Y., Shoji T., Maekawa K., et al. Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 41 suppl 1 (2003) S76-S79
13. Wang T.J., Larson M.G., Levy D., et al. C-Reactive protein is associated with subclinical epicardial coronary calcification in men and women: The Framingham Heart Study. Circulation 106 (2002) 1189-1191
14. Lebreton J.P., Joisel F., Raoult J.P., et al. Serum concentration of human α2HS glycoprotein during inflammatory process. Evidence that α2HS glycoprotein is a negative acute-phase reactant. J Clin Invest 64 (1978) 1118-1129
15. Memoli B., Bartolo L., Favia P., et al. Fetuin-A gene expression, synthesis and release in primary human hepatocytes cultured in a galactosylated membrane bioreactor. Biomaterials 28 (2007) 4836-4844
16. Wang A.Y., Woo J., Lam C.W., et al. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant 20 (2005) 1676-1685
17. Stenvinkel P., Wang K., Qureshi A.R., et al. Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int 67 (2005) 2383-2392
18. Benedetto F.A., Mallamaci F., Tripepi G., et al. Prognostic value of ultrasonographic measurement of carotid intima media thickness in dialysis patients. J Am Soc Nephrol 12 (2001) 2458-2464
19. Mathews S.T., Singh G.P., Ranalletta M., et al. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes 51 (2002) 2450-2458
20. Haasemann M., Nawratil P., and Muller-Esterl W. Rat tyrosine kinase inhibitor shows sequence similarity to human alpha 2-HS glycoprotein and bovine fetuin. Biochem J 274 (1991) 899-902
21. Heldin C.H. Signal transduction: Multiple pathways, multiple options for treatment. Stem Cells 19 (2001) 295-303
22. Levitzki A. PDGF receptor tyrosine kinase inhibitors for the treatment of restenosis. Cardiovasc Res 65 (2005) 581-586
23. Clemmons D.R. Modifying IGF-1 activity: An approach to treat endocrine diseases, atherosclerosis and cancer. Nat Rev Drug Discov 6 (2007) 821-833
24. Szweras M., Liu D., Partridge E.A., et al. Alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. J Biol Chem 277 (2002) 19991-19997
25. Singh N.N., and Ramji D.P. The role of transforming growth factor-beta in atherosclerosis. Cytokine Growth Factor Rev 17 (2006) 487-499
26. Mehrotra R. Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int 72 (2007) 137-140
27. Price P.A., and Lim J.E. The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem 278 (2003) 22144-22152