Fetuin-A gene expression, synthesis and release in primary human hepatocytes cultured in a galactosylated membrane bioreactor

Biomaterials

Volumn 28, Issue 32, 2007, Pages 4836-4844

  Memoli, Bruno ^a   De Bartolo, Loredana ^b   Favia, Pietro ^c   Morelli, Sabrina ^b   Lopez, Linda C ^c   Procino, Alfredo ^a   Barbieri, Giuseppe ^b   Curcio, Efrem ^d   Giorno, Lidietta ^b   Esposito, Pasquale ^a   Cozzolino, Mario ^e   Brancaccio, Diego ^e   Andreucci, Vittorio E ^a   d'Agostino, Riccardo ^c   Drioli, Enrico ^b,d  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b INSTITUTE ON MEMBRANE TECHNOLOGY   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITY OF CALABRIA   (Italy)

^e SAN PAOLO HOSPITAL   (Italy)

Author keywords

Bioreactor; Fetuin A; Galactosylated membrane; Hepatocytes; IL 6; Inflammation

Indexed keywords

GALACTOSYLATED MEMBRANE BIOREACTORS; HEPATOCYTES; INFLAMMATION;

BIOLOGICAL ORGANS; BIOREACTORS; GENE EXPRESSION; SYNTHESIS (CHEMICAL);

CELL CULTURE;

C REACTIVE PROTEIN; FETUIN; FETUIN A; GALACTOSE; INTERLEUKIN 6; UNCLASSIFIED DRUG;

ACUTE PHASE RESPONSE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME MEMBRANE BIOREACTOR; ENZYME RELEASE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LIVER CELL; LIVER CELL CULTURE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION;

BIOREACTORS; BLOOD PROTEINS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; GALACTOSE; GENE EXPRESSION; HEPATOCYTES; HUMANS; INTERLEUKIN-6; LIVER, ARTIFICIAL; MEMBRANES, ARTIFICIAL; TISSUE ENGINEERING;

EID: 34548022299     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.05.043     Document Type: Article

References (40)

1. Memoli B., Libetta C., Rampino T., Dal Canton A., Conte G., Scala G., et al. Hemodialysis related induction of interleukin-6 production by peripheral blood mononuclear cells. Kidney Int 42 (1992) 320-326
2. Libetta C., De Nicola L., Rampino T., De Simone W., and Memoli B. Inflammatory effects of peritoneal dialysis: evidence of systemic monocyte activation. Kidney Int 49 (1996) 506-511
3. Memoli B., Postiglione L., Cianciaruso B., Bisesti V., Cimmaruta C., Marzano L., et al. Role of different dialysis membranes in the release of interleukin 6 soluble receptor in uremic patients. Kidney Int 58 (2000) 417-424
4. Memoli B., Minutolo R., Bisesti V., Postiglione L., Conti A., Marzano L., et al. Changes of serum albumin and C-reactive protein are related to changes of interleukin 6 release by peripheral blood mononuclear cells in hemodialysis patients treated with different membranes. Am J Kidney Dis 39 (2002) 266-273
5. Memoli B., Grandaliano G., Soccio M., Postiglione L., Guida B., Bisesti V., et al. In vivo modulation of soluble "antagonist" IL-6 receptor synthesis and release in end stage renal disease. J Am Soc Nephrol 16 (2005) 1099-1107
6. Stenvinkel P., Barany P., Heimburger O., Pecoits-Filho R., and Lindholm B. Mortality, malnutrition, and atherosclerosis in ESRD: what is the role of interleukin 6?. Kidney Int 61 Suppl 80 (2002) S103-S108
7. Stenvinkel P., Ketteler M., Johnson R.J., Lindholm B., Pecoits-Filho R., Riella M., et al. IL-10, IL-6, and TNF-α: central factors in the altered cytokine network of uremia-the good, the bad, and the ugly. Kidney Int 67 (2005) 1216-1233
8. Nishimoto N., and Kishimoto T. Inhibition of IL-6 for the treatment of inflammatory diseases. Curr Opin Pharmacol 4 (2004) 386-391
9. Ito H., Takazoe M., Fukuda Y., Hibi T., Kusugami K., Andoh A., et al. A pilot randomized trial of a human anti-interleukin 6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126 (2004) 989-996
10. De Bartolo L., and Bader A. Review of a flat membrane as a bioartificial liver. Ann Transpl 6 (2001) 40-46
11. Strain A.J., and Neuberger J.M. A bioartificial liver-state of the art. Science 295 (2002) 1005-1009
12. De Bartolo L., Salerno S., Morelli S., Giorno L., Rende M., Memoli B., et al. Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor. Biomaterials 27 (2006) 4794-4803
13. Curcio E., De Bartolo L., Barbieri G., Rende M., Giorno L., Morelli S., et al. Diffusive and convective transport through hollow fiber membranes for liver cell culture. J Biotechnol 117 (2005) 309-321
14. Flendrig L.M., La Soe J.W., Joerning G.G.A., Steenbeck A., Karlsen O.T., Bovée W.M.M., et al. In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates. J Hepatol 26 (1997) 1379-1392
15. Gerlach J., Schnoy N., Smith M.D., and Neuhaus P. Hepatocyte culture between woven capillary networks-a microscopy study. Artif Organs 18 (1994) 226-230
16. Jauregui H.O., Mullon C.J.P., Trenkler D., Naik S., Santangini H., Press P., et al. In vivo evaluation of a hollow fiber liver assist device. Hepatology 21 (1995) 460-469
17. Nyberg S.L., Shirabe K., Peshwa M.W., Sielaff T.D., Crotty P.L., Mann H.J., et al. Extracorporeal application of a gel-entrapment, bioartificial liver: demonstration of drug metabolism and other biochemical functions. Cell Transplant 2 6 (1993) 441-452
18. Patzer J.F. Advances in bioartificial liver assist devices. Ann N Y Acad Sci 944 (2001) 320-333
19. De Bartolo L., Jarosch-Von Schweder G., Haverich A., and Bader A. A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions. Biotechnol Prog 16 (2000) 102-108
20. Dunn J.C., Tompkins R.G., and Yarmush M.L. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 7 3 (1991) 237-245
21. Sanchez A., Alvarez Pagan R., Roncero C., Vilaro S., Benito M., and Fabregat I. Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture. J Hepatol 32 2 (2000) 242-250
22. Lu H.F., Lim W.S., Wang J., Tang Z.Q., Zhang P.C., Leong K.W., et al. Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance. Biomaterials 24 27 (2003) 4893-4903
23. De Bartolo L., Morelli S., Lopez L., Giorno L., Campana C., Salerno S., et al. Biotransformation and liver specific functions of human hepatocytes in culture on RGD-immobilised plasma-processed membranes. Biomaterials 26 21 (2005) 4432-4441
24. Park T.G. Perfusion culture of hepatocytes within galactose-derivatized biodegradable poly(lactide-co-glycolide) scaffolds prepared by gas foaming of effervescent salts. J Biomed Mater Res 59 (2002) 127-135
25. De Bartolo L., Morelli S., Rende M., Salerno S., Giorno L., Lopez L.C., et al. Galactose derivative immobilized glow discharge processed PES membranes maintain the metabolic activity of human and pig liver cells. J Nanosci Nanotech 6 (2006) 2344-2353
26. Ketteler M., Bongartz P., Westenfeld R., Wildberger J.E., Mahnken A.H., Bohm R., et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 361 (2003) 827-833
27. Honda H., Qureshi A.R., Heimburger O., Barany P., Wang K., Pecoits-Filho R., et al. Serum albumin, C-reactive protein, interleukin 6, and fetuin-A as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis 47 (2006) 139-148
28. Detomaso L., Gristina R., Senesi G.S., d'Agostino R., and Favia P. Stable plasma-deposited acrylic acid surfaces for cell culture applications. Biomaterials 26 (2005) 3831-3841
29. De Bartolo L., Salerno S., Giorno L., Morelli S., Barbieri G., Curcio E., et al. Membrane bioreactor using pig hepatocytes for in vitro evaluation of antinflammatory drug. Catal Today 118 (2006) 172-180
30. Griffith L.G., and Naughton G. Tissue engineering-current challenges and expanding opportunities. Science 295 (2002) 1009-1014
31. Bader A., Fruhauf N., Tiedge M., Drinkgern M., De Bartolo L., Borlak J.T., et al. Enhanced oxygen delivery reverses anaerobic metabolic states in prolonged sandwich rat hepatocyte culture. Exp Cell Res 246 (1999) 221-232
32. Reynolds J.L., Skepper J.N., McNair R., Kasama T., Gupta K., Weissberg P.L., et al. Multifunctional roles for serum protein fetuin-A in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 16 (2005) 2920-2930
33. Triffitt J.T., Gebauer U., Ashton B.A., and Owen M.E. Origin of plasma α2HS-glycoprotein and its accumulation in bone. Nature 262 (1976) 226-227
34. Lebreton J.P., and Joisel F. Serum concentration of human alpha2 HS glycoprotein during the inflammatory process. J Clin Invest 64 (1979) 1118-1129
35. Ohnishi T., Nakamura O., Arakaki N., Miyazaki H., and Daikuhara Y. Effects of cytokines and growth factors on phosphorylated fetuin biosynthesis by adult rat hepatocytes in primary culture. Biochem Biophys Res Commun 200 (1994) 598-605
36. Daveau M., Davrinche C., Julen N., Hiron M., Arnaud P., and Lebreton J.P. The synthesis of human α2-HS glycoprotein is down-regulated by cytokines in hepatoma HepG2 cells. FEBS Lett 241 (1988) 191-194
37. Gangneux C., Daveau M., Hiron M., Derambure C., Papaconstantinou J., and Salier J.-P. the inflammation-induced down-regulation of plasma fetuin-A (α2HS-glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites. Nucleic Acid Res 31 20 (2003) 5957-5970
38. Wilkening S., Stahl F., and Bader A. Comparison of primary human hepatocytes and hepatoma cell line HEPG2 with regard to their biotransformation properties. Drug Metab Dispos 31 (2003) 1035-1042
39. Guillozo A., Morel F., Langouet S., Maheo K., and Rissel M. Use of hepatocyte cultures for study of hepatotoxic compounds. J Hepatol 26 Suppl 2 (1997) 23-80
40. Stenvinkel P., Wang K., Qureshi A.R., Axelsson J., Pecoits-Filho R., Gao P., et al. Low fetuin-A are associated with cardiovascular death: impact of variations in the gene encoding fetuin. Kidney Int 67 (2005) 2383-2392