Absorption pharmacokinetics of clonidine nasal drops in children

Paediatric Anaesthesia

Volumn 19, Issue 3, 2009, Pages 257-261

  Almenrader, Nicole ^a   Larsson, Peter ^b   Passariello, Maurizio ^a   Haiberger, Roberta ^a   Pietropaoli, Paolo ^a   Lönnqvist, Per Arne ^b   Eksborg, Staffan ^c  

^a POLICLINICO UMBERTO I   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Children; Clonidine; Pharmacokinetics

Indexed keywords

CLONIDINE; NOSE DROPS;

ANESTHESIA INDUCTION; ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; COMPUTER AIDED DESIGN; CONFIDENCE INTERVAL; CONTROLLED STUDY; CURVE FITTING; DRUG ADSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; GENERAL ANESTHESIA; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NOSE MUCOSA; PREMEDICATION; PRESCHOOL CHILD; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ADMINISTRATION, INTRANASAL; ADRENERGIC ALPHA-AGONISTS; ANESTHESIA, GENERAL; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONIDINE; FEMALE; HUMANS; INFANT; MALE; NASAL MUCOSA; PHARMACEUTICAL SOLUTIONS; PREANESTHETIC MEDICATION; SPECTRUM ANALYSIS;

EID: 60349097545     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2008.02886.x     Document Type: Article

References (12)

1. Mikawa K, Maekawa N, Nishina K et al. Efficacy of oral clonidine premedication in children. Anesthesiology 1993 79 : 926 931.
2. Bergendahl HTG, Lonnqvist PA, Eksborg S et al. Clonidine vs midazolam as premedication in children undergoing adeno-tonsillectomy: a prospective, randomized, controlled clinical trial. Acta Anaesthesiol Scand 2004 48 : 1292 1300.
3. Davies DS, Wing LMH, Reid JL et al. Pharmacokinetics and concentration-effect relationship of intravenous and oral clonidine. Clin Pharmacol Ther 1977 21 : 593 601.
4. Lonnqvist PA, Bergendahl HTG, Eksborg S. Pharmacokinetics of clonidine after rectal administration in children. Anesthesiology 1994 81 : 1097 1101.
5. Potts AL, Larsson P, Eksborg S et al. Clonidine disposition in children: a population analysis. Paediatr Anaesth 2007 17 : 924 933.
6. Almenrader N, Passariello M, Coccetti B et al. Steal-induction after clonidine premedication: a comparison of the oral and nasal route. Paediatr Anaesth 2007 17 : 230 234.
7. Babhair SA, Tariq M, Abdullah ME. Comparison of intravenous and nasal bioavailability of clonidine in rats. Res Commun Mol Pathol Pharmacol 1990 67 : 241 248.
8. Behl CR, Pimplaskar HK, Sileno AP et al. Effects of physicochemical properties and other factors on systemic drug delivery. Adv Drug Deliv Rev 1998 29 : 89 116.
9. Galinkin JL, Fazi LM, Cuy RM et al. Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia. Anesthesiology 2000 93 : 1378 1383.
10. Ivani G, Bergendahl HTG, Lampugnani E et al. Plsama levels of clonidine following epidural bolus injection in children. Acta Anaesthesiol Scand 1998 42 : 306 311.
11. Lowenthal DT. Pharmacokinetics of clonidine. J Cardiovasc Pharmacol 1980 2 (Suppl. 1 S29 S37.
12. Keränen a, Nykänen S, Taskinen J. Pharmacokinetics and side-effects of clonidine. Eur J Clin Pharmacol 1978 13 : 97 101.