7-Difluoromethyl-5,4′-dimethoxygenistein inhibits oxidative stress induced adhesion between endothelial cells and monocytes via NF-κB

European Journal of Pharmacology

Volumn 605, Issue 1-3, 2009, Pages 31-35

  Wang, Li ^a   Zheng, Xing ^a   Xiang, Hong lin ^b   Fu, Xiao hua ^b   Cao, Jian guo ^b  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

7 Difluoromethyl 5,4 dimethoxygenistein; Adhesion; Endothelial cell; Inflammation; Monocyte; NF B; Oxidative stress

Indexed keywords

7 DIFLUOROMETHYL 5,4 DIMETHOXYGENISTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL INTERACTION; CELL SECRETION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL ADHESION; CELL LINE; DOWN-REGULATION; E-SELECTIN; ENDOTHELIAL CELLS; GENISTEIN; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MONOCYTES; NF-KAPPA B; OXIDATIVE STRESS; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL CORD;

EID: 60349083949     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.019     Document Type: Article

References (28)

1. Ahn K.S., and Aggarwal B.B. Transcription factor NF-{kappa}B: a sensor for smoke and stress signals. Ann. N. Y. Acad. Sci. 10 (2005) 218-233
2. Ando J., and Kamiya A. Blood flow and vascular endothelial cell function. Front. Med. Biol. Eng. 5 (1993) 245-264
3. Barton B.E. IL-6: insights into novel biological activities. Clin. Immunol. Immunopathol. 85 (1997) 16-20
4. Bourteele S., Oesterle K., Weinzierl A.O., Paxian S., Riemann M., Schmid R.M., and Planz O. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Cell. Microbiol. 9 (2007) 2202-2217
5. Devaux C., Varin R., Mulder P., Richard V., and Thuillez C. Oxidative stress and endothelial dysfunction in heart failure. Therapie 56 (2001) 575-581
6. Fu X.H., Wang L., Zhao H., Xiang X.L., and Cao J.G. Synthesis of genistein derivatives and determination of their protective effects against vascular endothelial cell damages caused by hydrogen peroxide. Bioorg. Med. Chem. Lett. 18 (2008) 513-517
7. Fuchs D., Erhard P., Rimbach G., Daniel H., and Wenzel U. Genistein blocks homocysteine-induced alterations in the proteome of human endothelial cells. Proteomics 5 (2005) 2808-2818
8. Hernandez-Montes E., Pollard S.E., Vauzour D., Jofre-Montseny L., Rota C., Rimbach G., Weinberg P.D., and Spencer J.P. Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury. Biochem. Biophys. Res. Commun. 346 (2006) 851-859
9. Huang R., Shi F., Lei T., Song Y., Hughes C.L., and Liu G. Effect of the isoflavone genistein against galactose-induced cataracts in rats. Exp. Biol. Med. 232 (2007) 118-125
10. Kroom P.A., Clifford M.N., Crozier A., Day A.J., Donovan J.L., Manach C., and Williamson G. How should we assess the effects of exposure to dietary polyphenols in vitro?. Am. J. Clin. Nutr. 80 (2004) 15-21
11. Kurowska E.M. Nitric oxide therapies in vascular diseases. Curr. Pharm. Des. 8 (2002) 155-166
12. Kuzu N., Metin K., Dagli A.F., Akdemir F., Orhan C., Yalniz M., Ozercan I.H., Sahin K., and Bahcecioglu I.H. Protective role of genistein in acute liver damage induced by carbon tetrachloride. Mediat. Inflamm. 2007 (2007) 36381
13. Kwan H.Y., Huang Y., and Yao X. TRP channels in endothelial function and dysfunction. Biochim. Biophys. Acta. 1772 (2007) 907-914
14. Kwon S.H., Kang M.J., Huh J.S., Ha K.W., Lee J.R., Lee S.K., Lee B.S., Han I.H., Lee M.S., Lee M.W., Lee J., and Choi Y.W. Comparison of oral bioavailability of genistein and genistin in rats. Int. J. Pharm. 337 (2007) 148-154
15. Lee C.S., Kwon S.J., Na S.Y., Lim S.P., and Lee J.H. Genistein supplementation inhibits atherosclerosis with stabilization of the lesions in hypercholesterolemic rabbits. J. Korean Med. Sci. 19 (2004) 656-661
16. Liu S.F., and Malik A.B. NF-{kappa}B activation as a pathological mechanism of septic shock and inflammation. Am. J. Physiol., Lung Cell. Mol. Physiol. 290 (2006) L622-645
17. Ma G., Khan S.I., Benavides G., Schuhly W., Fischer N.H., Khan I.A., and Pasco D.S. Inhibition of NF-kappaB-mediated transcription and induction of apoptosis by melampolides and repandolides. Cancer Chemother. Pharmacol. 60 (2007) 35-43
18. Martin J., Collot-Teixeira S., McGregor L., and McGregor J.L. The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. Curr. Pharm. Des. 13 (2007) 1751-1759
19. Nakabe N., Kokura S., Shimozawa M., Katada K., Sakamoto N., Ishikawa T., Handa O., Takagi T., Naito Y., Yoshida N., and Yoshikawa T. Hyperthermia attenuates TNF-alpha-induced up regulation of endothelial cell adhesion molecules in human arterial endothelial cells. Int. J. Hypertherm. 23 (2007) 217-224
20. Perrault L.P., Manlberq F., Breuqnot C., Bidouard J.P., Villeneuve N., Vilaine J.P., and Vanhoutte P.M. Hypercholesterolemia increases coronary endothelial dysfunction, lipid content, and accelerated atherosclerosis after heart transplantation. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 728-736
21. Piao M., Mori D., Satoh T., Sugita Y., and Tokunaga O. Inhibition of endothelial cell proliferation, in vitro angiogenesis, and the down-regulation of cell adhesion-related genes by genistein. Combined with a cDNA microarray analysis. Endothelium 13 (2006) 249-266
22. Sainani G.S., and Sainani R. Homocysteine and its role in the pathogenesis of atherosclerotic vascular disease. J. Assoc. Phys. India 50 (2002) 16-23 (Suppl)
23. Taddei S., Virdis A., Ghiadoni L., Versari D., and Salvetti A. Endothelium, aging, and hypertension. Curr. Hypertens. Rep. 8 (2006) 84-89
24. Tuo Q.H., Wang C., Yan F.X., and Liao D.F. MAPK pathway mediates the protective effects of onychin on oxidative stress-induced apoptosis in ECV304 endothelial cell. Life Sci. 76 (2004) 487-497
25. Wang X., Hussain S., Wang E.J., Wang X., Li M.O., Garcia-Sastre A., and Beg A.A. Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression. J. Immunol. 178 (2007) 6770-6776
26. Yoon H., and Liu R.H. Effect of selected phytochemicals and apple extracts on NF-kappaB activation in human breast cancer MCF-7 cells. J. Agric. Food Chem. 55 (2007) 3167-3173
27. Yung L.M., Leung F.P., Yao X., Cheng Z.Y., and Huang Y. Reactive oxygen species in vascular wall. Cardiovasc. Hematol. Disord. Drug. Targets 6 (2006) 1-19
28. Zhang J.Y., Cao Y.X., Xu C.B., and Edvinsson L. Lipid-soluble smoke particles damage endothelial cells and reduce endothelium-dependent dilatation in rat and man. BMC Cardiovasc. Disord. 6 (2006) 3