Angiosarcomas arising in the viscera and soft tissue of children and young adults: A clinicopathologic study of 15 cases

American Journal of Surgical Pathology

Volumn 33, Issue 2, 2009, Pages 264-269

  Deyrup, Andrea T ^a   Miettinen, Markku ^c   North, Paula E ^d   Khoury, Joseph D ^e   Tighiouart, Mourad ^b   Spunt, Sheri L ^f   Parham, David ^g,h   Weiss, Sharon W ^a   Shehata, Bahig M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^g UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^h ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Angiosarcoma; Pediatric; Podoplanin; Soft tissue; Viscera

Indexed keywords

PODOPLANIN;

ADULT; ANGIOSARCOMA; ARTICLE; BODY REGIONS; CANCER GRADING; CANCER SURVIVAL; CELL SHAPE; CLINICAL ARTICLE; CLINICAL FEATURE; CONSULTATION; CONTROLLED STUDY; DEMOGRAPHY; EPITHELIOID CELL; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MITOSIS RATE; NECROSIS; PROTEIN EXPRESSION; SOFT TISSUE; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR VOLUME; VISCERA; ADOLESCENT; CHILD; INFANT; KAPLAN MEIER METHOD; MORTALITY; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; SOFT TISSUE TUMOR;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; HEMANGIOSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; KAPLAN-MEIERS ESTIMATE; MALE; PROGNOSIS; SOFT TISSUE NEOPLASMS; VISCERA;

EID: 60249102545     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181875a5f     Document Type: Article

References (35)

1. Alt B, Hafez GR, Trigg M, et al. Angiosarcoma of the liver and spleen in an infant. Pediatr Pathol. 1985;4:331-339.
2. Billings SD, McKenney JK, Folpe AL, et al. Cutaneous angiosar-coma following breast-conserving surgery and radiation: an analysis of 27 cases. Am J Surg Pathol. 2004;28:781-788.
3. Booth AM, LeGallo RD, Stoler MH, et al. Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern. Pediatr Dev Pathol. 2001;4:490-495.
4. Brenn T, Fletcher CD. Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol. 2005;29:983-996.
5. Burke AP, Virmani R. Tumors of the Heart and Great Vessels. Washington, DC: Armed Forces Institute of Pathology; 1996: 119-122.
6. Coffin CM, Dehner LP. Vascular tumors in children and adolescents: a clinicopathologic study of 228 tumors in 222 patients. Pathol Annu. 1993;28(Pt 1):97-120.
7. den Bakker MA, Flood SJ, Kliffen M. CD31 staining in epithelioid sarcoma. Virchows Arch. 2003;443:93-97.
8. Fayette J, Martin E, Piperno-Neumann S, et al. Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol. 2007; 18:2030-2036.
9. Ferrari A, Casanova M, Bisogno G, et al. Malignant vascular tumors in children and adolescents: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group. Med Pediatr Oncol. 2002;39:109-114.
10. Folpe AL, Chand EM, Goldblum JR, et al. Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol. 2001;25:1061-1066.
11. Fujii T, Zen Y, Sato Y, et al. Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol. 2008;21:125-130.
12. Hodgson NC, Bowen-Wells C, Moffat F, et al. Angiosarcomas of the breast: a review of 70 cases. Am J Clin Oncol. 2007;30:570-573.
13. Hsu JT, Chen HM, Lin CY, et al. Primary angiosarcoma of the spleen. J Surg Oncol. 2005;92:312-316.
14. Hsu JT, Ueng SH, Hwang TL, et al. Primary angiosarcoma of the spleen in a child with long-term survival. Pediatr Surg Int. 2007; 23:807-810.
15. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15:434-440.
16. Kim CH, Dancer JY, Coffey D, et al. Clinicopathologic study of 24 patients with primary cardiac sarcomas: a 10-year single institution experience. Hum Pathol. 2008;39:933-938.
17. Kren L, Kaur P, Goncharuk VN, et al. Primary angiosarcoma of the spleen in a child. Med Pediatr Oncol. 2003;40:411-412.
18. Kubac G, Gelfand ET, Machin GA, et al. Angiosarcoma of the heart. Can J Cardiol. 1991;7:249-252.
19. Lezama-del Valle P, Gerald WL, Tsai J, et al. Malignant vascular tumors in young patients. Cancer. 1998;83:1634-1639.
20. Lyons LL, North PE, Mac-Moune Lai F, et al. Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile heman-gioma. Am J Surg Pathol. 2004;28:559-568.
21. Malagon HD, Valdez AM, Moran CA, et al. Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol. 2007;31: 1356-1362.
22. Meis-Kindblom JM, Kindblom LG. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol. 1998;22:683-697.
23. Miettinen M, Fanburg-Smith JC, Virolainen M, et al. Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis. Hum Pathol. 1999;30:934-942.
24. Morgan MB, Swann M, Somach S, et al. Cutaneous angiosarcoma: a case series with prognostic correlation. J Am Acad Dermatol. 2004; 50:867-874.
25. Nakamichi T, Fukuda T, Suzuki T, et al. Primary cardiac angiosarcoma: 53 months' survival after multidisciplinary therapy. Ann Thorac Surg. 1997;63:1160-1161.
26. Nord KM, Kandel J, Lefkowitch JH, et al. Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics. 2006;118:e907-e913.
27. Noronha R, Gonzalez-Crussi F. Hepatic angiosarcoma in childhood. A case report and review of the literature. Am J Surg Pathol. 1984;8:863-871.
28. Pawlik TM, Paulino AF, McGinn CJ, et al. Cutaneous angiosarcoma of the scalp: a multidisciplinary approach. Cancer. 2003;98: 1716-1726.
29. Selby DM, Stocker JT, Ishak KG. Angiosarcoma of the liver in childhood: a clinicopathologic and follow-up study of 10 cases. Pediatr Pathol. 1992;12:485-498.
30. Sher T, Hennessy BT, Valero V, et al. Primary angiosarcomas of the breast. Cancer. 2007;110:173-178.
31. Simpson L, Kumar SK, Okuno SH, et al. Malignant primary cardiac tumors: review of a single institution experience. Cancer. 2008;112:2440-2446.
32. Stewart FW, Treves N. Lymphangiosarcoma in postmastectomy lymphedema. Cancer. 1949;1:64.
33. von Hochstetter AR, Meyer VE, Grant JW, et al. Epithelioid sarcoma mimicking angiosarcoma: the value of immunohistochemistry in the differential diagnosis. Virchows Arch A Pathol Anat Histopathol. 1991;418:271-278.
34. Vorburger SA, Xing Y, Hunt KK, et al. Angiosarcoma of the breast. Cancer. 2005;104:2682-2688.
35. Weiss SW, Goldblum J. Enzinger and Weiss's Soft Tissue Tumors. St Louis, MO: Mosby; 2007.