Sophorolipids as Antibacterial Agents

Annals of Clinical and Laboratory Science

Volumn 39, Issue 1, 2009, Pages 60-63

  Sleiman, Joseph N ^a   Kohlhoff, Stephan A ^a   Roblin, Patricia M ^a   Wallner, Sabine ^a   Gross, Richard ^a   Hammerschlag, Margaret R ^a   Zenilman, Michael E ^b   Bluth, Martin H ^c  

^a SUNY Downstate Medical Center   (United States)

^b POLYTECHNIC UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti bacterial agents; Anti inflammatory agents; Glycolipids; Sophorolipids

Indexed keywords

ACIDIC SOPHOROLIPID; ANTIBIOTIC AGENT; CEFOTAXIME; CEFTAZIDIME; ETHYL ESTER DIACETATE; ETHYL ESTER MONOACETATE; LACTONIC SOPHOROLIPID DIACETATE; METHYL ESTER; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL FLORA; BACTERIUM ISOLATE; BROTH DILUTION; CANDIDA; CANDIDA BOMBICOLA; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SYNTHESIS; ESCHERICHIA COLI; HOST; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIA; GLYCOLIPIDS; MICROBIAL SENSITIVITY TESTS;

ANIMALIA; BACTERIA (MICROORGANISMS); RATTUS;

EID: 60249099586     PISSN: 00917370     EISSN: 15508080     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Shah, V, Doncel GF, Seyoum T, Eaton KM, Zalenskaya I, Hagver R, Azim A, Gross R. Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities. Antimicrob Agents Chemother 2005;49:4093-4100.
2. Fu SL, Wallner SR, Bowne WB, Hagler MD, Zenilman ME, Gross R, Bluth MH. Sophorolipids and their derivatives are lethal against human pancreatic cancer cells. J Surg Res 2008;148:77-82.
3. Chen J, Song X, Zhang H, Qu YB, Miao JY. Sophorolipid produced from the new yeast strain Wickerhamiella domercqiae induces apoptosis in H7402 human liver cancer cells. Appl Microbiol Biotechnol 2006;72:52-59.
4. Bluth MH, Kandil E, Mueller CM, Shah V, Lin YY, Zhang H, Dresner L, Lempert L, Nowakowski M, Gross R, Schulze R, Zenilman ME. Sophorolipids block lethal effects of septic shock in rats using a cecal ligation and puncture model of experimental sepsis. Crit Care Med 2006;34:188-195.
5. Hardin R, Pierre J, Schulze R, Mueller CM, Fu S, Wallner S, Stanek A, Shah V, Gross R, Weedon J, Nowakowski M, Zenilman M, Bluth MH. Sophorolipids improve sepsis survival: Effects of dosing and derivatives. J Surg Res 2007;142:314-319.
6. Fu SL, Mueller MC, Lin YY, Viterbo D, Pierre J, Shah V, Gross R, Schulze R, Zenilman ME, Bluth MH. Sophorolipid treatment decreases LPS induced inflammatory responses and NO production in macrophages. J Am Col Surg 2007;S44:205.
7. Bluth MH, Hardin R, Pierre J, Chapman M, Viterbo D, Lin YY, Mueller CM, Chice S, Schulze R, Smith-Norowitz TA, Nowakowski M, Kandil E, Shah V, Gross RA, Zenilman ME. Sophorolipid treatment modulates leukocyte adhesion molecule profiles in intra-abdominal sepsis. FASEB J 2005;19:A352.
8. Hagler M, Smith-Norowitz TA, Chice S, Wallner, S, Viterbo D, Mueller CM, Gross R, Nowakowski M, Schulze R, Zenilman ME, Bluth MH. Sophorolipids decrease IgE production in U266 cells by downregulation of BSAP (Pax5), TLR2, STAT3 and IL-6. J Allergy Clin Immunol 2007;119:S263.
9. Clinical and Laboratory Standards Institute. Standard methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved Standard M7-A6. CLSI, Wayne, Pa, USA, 2003.
10. Shah V, Badia D, Ratsep P. Sophorolipids having enhanced antibacterial activity. Antimicrob Agents Chemother 2007;51:397-400.
11. Kim KJ, Yoo D, Kim Y, Lee B, Shin D, Kim EK. Characteristics of sophorolipids as an antimicrobial agent. J Microbiol Biotechnol 2002;12:235-241.
12. Labro MT. Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother 1998;41:37-46.
13. Sapadin AN, Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006;54:258-265.