Sophorolipids and Their Derivatives Are Lethal Against Human Pancreatic Cancer Cells

Journal of Surgical Research

Volumn 148, Issue 1, 2008, Pages 77-82

  Fu, Sophia L ^a   Wallner, Sabine R ^b   Bowne, Wilbur B ^a   Hagler, Michael D ^a   Zenilman, Michael E ^a   Gross, Richard ^b   Bluth, Martin H ^a  

^a SUNY Downstate Medical Center   (United States)

^b POLYTECHNIC UNIVERSITY   (United States)

Author keywords

adenocarcinoma; cytotoxicity; glycolipid; necrosis; pancreatic cancer; sophorolipid

Indexed keywords

GLYCOLIPID; LACTATE DEHYDROGENASE; SOPHOROLIPID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; ENZYME MODIFICATION; ENZYME RELEASE; HUMAN; HUMAN CELL; NORMAL HUMAN; PANCREAS CARCINOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOLIPIDS; HUMANS; PANCREATIC NEOPLASMS;

EID: 51749090435     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.03.005     Document Type: Article

References (20)

1. Shaib Y., Davila J., Naumann C., et al. The impact of curative intent surgery on the survival of pancreatic cancer patients: A U.S. population-based study. Am J Gastroenterol 102 (2007) 1377
2. Saif MW. Pancreatic cancer: are we moving forward yet? Highlights from the Gastrointestinal Cancers Symposium. Orlando, FL, USA. January 20th, 2007. JOP 2007;8:166.
3. Zamai M., VandeVen M., Farao M., et al. Camptothecin poly[n-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: intratumor release and antitumor efficacy. Mol Cancer Ther 2 (2003) 29
4. Aung K.L., Smith D.B., and Neoptolemos J.P. Adjuvant therapy for pancreatic cancer. Exp Opin Pharmacother 8 (2007) 2533
5. Isoda H., Shinmoto H., Matsumura M., et al. Succinoyl trehalose lipid induced differentiation of human monocytoid leukemic cell line U937 into monocyte-macrophages. Cytotechnology 19 (1995) 79
6. Preetha A., Banerjee R., and Huilgol N. Surface activity, lipid profiles and their implications in cervical cancer. J Cancer Res Ther 1 (2005) 180
7. Van Brocklyn J.R. Sphingolipid signaling pathways as potential therapeutic targets in gliomas. Mini Rev Med Chem 7 (2007) 984
8. Wu P., Qi B., Zhu H., et al. Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1. Cancer Lett 256 (2007) 64
9. Matsubara K., Matsumoto H., Mizushina Y., et al. Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis. Oncol Rep 14 (2005) 157
10. Zhu X.F., Zhang X.S., Li Z.M., et al. Apoptosis induced by ceramide in hepatocellular carcinoma Bel7402 cells. Acta Pharmacol Sin 21 (2000) 225
11. Singh S.K., Felse A.P., Nunez A., et al. Regioselective enzyme-catalyzed synthesis of sophorolipid esters, amides, and multifunctional monomers. J Org Chem 68 (2003) 5466
12. Bluth M.H., Kandil E., Mueller C.M., et al. Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis. Crit Care Med 34 (2006) 188
13. Hardin R., Pierre J., Schulze R., et al. Sophorolipids improve sepsis survival: Effects of dosing and derivatives. J Surg Res 142 (2007) 314
14. Shah V., Doncel G.F., Seyoum T., et al. Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities. Antimicrob Agents Chemother 49 (2005) 4093
15. Sun X.X., Lee Y.J., Choi J.K., et al. Synergistic effect of sophorolipid and loess combination in harmful algal blooms mitigation. Mar Pollut Bull 48 (2004) 863
16. Chen J., Song X., Zhang H., et al. Sophorolipid produced from the new yeast strain Wickerhamiella domercqiae induces apoptosis in H7402 human liver cancer cells. Appl Microbiol Biotechnol 72 (2006) 52
17. Bowne W.B., Michl J., Bluth M.H., et al. Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer. Cancer Ther 5B (2007) 331
18. Bluth M.H., Robin J., Ruditsky M., et al. IgE anti-Borrelia burgdorferi components (p18, p31, p34, p41, p45, p60) and increased blood CD8+CD60+ T cells in children with Lyme disease. Scand J Immunol 65 (2007) 376
19. Shah V., Jurjevic M., and Badia D. Utilization of restaurant waste oil as a precursor for sophorolipid production. Biotechnol Prog 23 (2007) 512
20. Miyamoto Y., Hosotani R., Doi R., et al. Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells. Anticancer Res 21 (2001) 2449