A Mechanistic Investigation Into How Long-Term Resynchronization Therapy Confers Ongoing Cardiac Functional Benefits and Improved Exercise Capacity

American Journal of Cardiology

Volumn 103, Issue 5, 2009, Pages 701-708

  Schlosshan, Dominik ^a   Barker, Diane ^a   Lewis, Nigel ^a   Pepper, Chris ^b   Tan, Lip Bun ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EXERCISE; FEMALE; HEART FAILURE; HEART FUNCTION; HEART OUTPUT; HEMODYNAMIC MONITORING; HUMAN; LONG TERM CARE; MALE; MEAN ARTERIAL PRESSURE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; CARDIAC PACING, ARTIFICIAL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; RESPIRATION; VENTRICULAR FUNCTION, LEFT;

EID: 60249095796     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2008.10.041     Document Type: Article

References (30)

1. Schlosshan D., Barker D., Pepper C., Williams G., Morley C., and Tan L.B. CRT improves the exercise capacity and functional reserve of the failing heart through enhancing the cardiac flow- and pressure-generating capacity. Eur J Heart Fail 8 (2006) 515-521
2. John Sutton M.G., Plappert T., Abraham W.T., Smith A.L., Delurgio D.B., Leon A.R., Loh E., Kocovic D.Z., Fisher W.G., Ellestad M., et al. Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure. Circulation 107 (2003) 1985-1990
3. Soliman O.I., Geleijnse M.L., Theuns D.A., Nemes A., Vletter W.B., van Dalen B.M., Motawea A.K., Jordaens L.J., and Ten Cate F.J. Reverse of left ventricular volumetric and structural remodeling in heart failure patients treated with cardiac resynchronization therapy. Am J Cardiol 101 (2008) 651-657
4. Gregoratos G., Abrams J., Epstein A.E., Freedman R.A., Hayes D.L., Hlatky M.A., Kerber R.E., Naccarelli G.V., Schoenfeld M.H., Silka M.J., and Winters S.L. ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices-summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE Committee to Update the 1998 Pacemaker Guidelines). J Am Coll Cardiol 40 (2002) 1703-1719
5. Cooke G.A., Marshall P., al Timman J.K., Wright D.J., Riley R., Hainsworth R., and Tan L.B. Physiological cardiac reserve: development of a non-invasive method and first estimates in man. Heart 79 (1998) 289-294
6. Elborn J.S., Stanford C.F., and Nicholls D.P. Reproducibility of cardiopulmonary parameters during exercise in patients with chronic cardiac failure. The need for a preliminary test. Eur Heart J 11 (1990) 75-81
7. 2 rebreathing. Med Sci Sports Exerc 32 (2000) 1028-1034
8. Meaney E., Alva F., Moguel R., Meaney A., Alva J., and Webel R. Formula and nomogram for the sphygmomanometric calculation of the mean arterial pressure. Heart 84 (2000) 64
9. Tan L.B. Clinical and research implications of new concepts in the assessment of cardiac pumping performance in heart failure. Cardiovasc Res 21 (1987) 615-622
10. Tan L.B. Evaluation of cardiac dysfunction, cardiac reserve and inotropic response. Postgrad Med J 67 suppl 1 (1991) S10-S20
11. Cohen-Solal A., Tabet J.Y., Logeart D., Bourgoin P., Tokmakova M., and Dahan M. A non-invasively determined surrogate of cardiac power ('circulatory power') at peak exercise is a powerful prognostic factor in chronic heart failure. Eur Heart J 23 (2002) 806-814
12. Chua T.P., Ponikowski P., Harrington D., Anker S.D., Webb-Peploe K., Clark A.L., Poole-Wilson P.A., and Coats A.J. Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol 29 (1997) 1585-1590
13. Cooke G.A., Williams S.G., Marshall P., al Timman J.K., Shelbourne J., Wright D.J., and Tan L.B. A mechanistic investigation of ACE inhibitor dose effects on aerobic exercise capacity in heart failure patients. Eur Heart J 23 (2002) 1360-1368
14. Ennezat P.V., Gal B., Kouakam C., Marquie C., LeTourneau T., Klug D., Lacroix D., Logeart D., Cohen-Solal A., Dennetiere S., et al. Cardiac resynchronisation therapy reduces functional mitral regurgitation during dynamic exercise in patients with chronic heart failure: an acute echocardiographic study. Heart 92 (2006) 1091-1095
15. Brandt R.R., Reiner C., Arnold R., Sperzel J., Pitschner H.F., and Hamm C.W. Contractile response and mitral regurgitation after temporary interruption of long-term cardiac resynchronization therapy. Eur Heart J 27 (2006) 187-192
16. Valzania C., Gadler F., Eriksson M.J., Olsson A., Boriani G., and Braunschweig F. Electromechanical effects of cardiac resynchronization therapy during rest and stress in patients with heart failure. Eur J Heart Fail 9 (2007) 644-650
17. Yu C.M., Chau E., Sanderson J.E., Fan K., Tang M.O., Fung W.H., Lin H., Kong S.L., Lam Y.M., Hill M.R., and Lau C.P. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 105 (2002) 438-445
18. Popovic Z.B., Grimm R.A., Perlic G., Chinchoy E., Geraci M., Sun J.P., Donal E., Xu X.F., Greenberg N.L., Wilkoff B.L., and Thomas J.D. Noninvasive assessment of cardiac resynchronization therapy for congestive heart failure using myocardial strain and left ventricular peak power as parameters of myocardial synchrony and function. J Cardiovasc Electrophysiol 13 (2002) 1203-1208
19. Boriani G., Saporito D., Biffi M., Martignani C., Valzania C., Diemberger I., Ziacchi M., Artale P., Grigioni F., Bacchi L., et al. Acute and chronic haemodynamic effects of biventricular pacing and of switching to different pacing modalities in heart failure patients. Int J Cardiol 110 (2006) 318-323
20. Knaapen P., van Campen L.M., de Cock C.C., Gotte M.J., Visser C.A., Lammertsma A.A., and Visser F.C. Effects of cardiac resynchronization therapy on myocardial perfusion reserve. Circulation 110 (2004) 646-651
21. Sundell J., Engblom E., Koistinen J., Ylitalo A., Naum A., Stolen K.Q., Kalliokoski R., Nekolla S.G., Airaksinen K.E., Bax J.J., and Knuuti J. The effects of cardiac resynchronization therapy on left ventricular function, myocardial energetics, and metabolic reserve in patients with dilated cardiomyopathy and heart failure. J Am Coll Cardiol 43 (2004) 1027-1033
22. Braunschweig F., Sorensen J., von Bibra H., Olsson A., Ryden L., Langstrom B., and Linde C. Effects of biventricular pacing on myocardial blood flow and oxygen consumption using carbon-11 acetate positron emission tomography in patients with heart failure. Am J Cardiol 92 (2003) 95-99
23. Leclercq C., Cazeau S., Le Breton H., Ritter P., Mabo P., Gras D., Pavin D., Lazarus A., and Daubert J.C. Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure. J Am Coll Cardiol 32 (1998) 1825-1831
24. Kass D.A., Chen C.H., Curry C., Talbot M., Berger R., Fetics B., and Nevo E. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 99 (1999) 1567-1573
25. Cotter G., Williams S.G., Vered Z., and Tan L.B. Role of cardiac power in heart failure. Curr Opin Cardiol 18 (2003) 215-222
26. Williams S.G., Jackson M., Cooke G.A., Barker D., Patwala A., Wright D.J., Albuoaini K., and Tan L.B. How do different indicators of cardiac pump function impact upon the long-term prognosis of patients with chronic heart failure?. Am Heart J 150 (2005) 983.e1-983.e6
27. Williams S.G., Cooke G.A., Wright D.J., and Tan L.B. Disparate results of ACE inhibitor dosage on exercise capacity in heart failure: a reappraisal of vasodilator therapy and study design. Int J Cardiol 77 (2001) 239-245
28. Sullivan M.J., Higginbotham M.B., and Cobb F.R. Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects. Circulation 78 (1988) 506-515
29. Kennedy R.R., and Baker A.B. Solubility characteristics of the ideal agent for measurement of cardiac output by soluble gas uptake methods. Br J Anaesth 71 (1993) 398-402
30. Jakovljevic D.G., Nunan D., Donovan G., Hodges L.D., Sandercock G.R., and Brodie D.A. Comparison of cardiac output determined by different rebreathing methods at rest and at peak exercise. Eur J Appl Physiol 102 (2008) 593-599