The butanol extract of Mitragyna ciliata root: Potential as a trypanocide

International Journal of Pharmacology

Volumn 4, Issue 2, 2008, Pages 102-107

  Ogbunugafor, H A ^a   Okochi, V I ^b   Okpuzor, J ^b   Odesanmi, O S ^b   Ebigwe, F J ^a  

^a NNAMDI AZIKIWE UNIVERSITY   (Nigeria)

^b UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Bioactive; Calcium; Mitragyna ciliata; Trypanocidal

Indexed keywords

ALKALOID DERIVATIVE; ANTITRYPANOSOMAL AGENT; BUTANOL; CALCIUM; MITRAGYNA CILIATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CALCIUM METABOLISM; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LEUKOPENIA; MALE; MITRAGYNA; MITRAGYNA CILIATA; NONHUMAN; PLANT ROOT; RAT; THROMBOCYTOPENIA; TOXICITY TESTING; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

EID: 60249094983     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.102.107     Document Type: Article

References (30)

1. Aji, B.M., P.A. Onyelili and U.A. Osunkwo, 2001. The central nervous effects of Mitragyna africanus (Willd.) stem bark extract in rats. J. Ethnopharmacol., 77 (2-3): 143-149.
2. Atawodi, S.E., T. Bulus, S. Ibrahim, D.A. Ameh, A.J. Nok, M. Mamman and M. Galadima, 2003. In vitro trypanocidal effect of methanolic extract of some Nigerian savannah plants. Afr. J. Biotechol., 2 (9): 317-321.
3. Atawodi, S.E., 2005. Comparative in vitro trypanocidal activities of petroleum ether, chloroform, methanol and aqueous extracts of some Nigerian savannah plants. Afr. J. Biotechnol., 4 (2): 177-182.
4. Atidehou, K.K., C. Schmid, R. Brun, M.W. Kone and D. Traore, 2004. Antitrypanosomal and antiplasmodial activity of medicinal plants from Cote d'Ivoire. J. Ethnopharmacol., 90 (2-3): 221-227.
5. Buchanan, K.T., J.B. Ames, S.H. Asfaw, A. Wingard, C.L. Oslon, P.T. Capana, A.U. Araujo and D. Egman, 2005. A flagellum-specific calcium sensor. J. Biol. Chem., 280 (48): 40104-40111.
6. Burchmore, R.J.S., P.O.J. Ogbunude, B. Enanga and M.P. Barrett, 2002. Chemotherapy of human African trypanosomiasis. Curr. Pharm. Des., 8 (4): 257-267.
7. Decampo, R. and S.N.J. Morenso, 2001. The acidocalsisomes. Mol. Biochem. Parasitol., 114 (2): 151-159.
8. De Koning, H.P., 2001. Transporter in African trypanosomes: Role in drug action and resistance. Int. J. Parasitol., 31 (5): 512-522.
9. Dongmo, A.B., A. Kamanyi, G. Dzikouk, N.B. Chungag-Anye, P.V. Tan, T. Nguelefack T. Nole, M. Bopellet and H. Wagner, 2003. Anti-inflammatory and analgesic properties of stem bark extract of Mitragyna ciliata (Rubiaceae) Aubrev. and Pellegr. J. Ethnopharmacol., 84 (1): 17-21.
10. Edeoga, H.O., D.E. Okwu and B.O. Mbaebie, 2005. Phytochemical constituents of some Nigerian plants. Afr. J. Biotechnol., 4 (7): 6885-6888.
11. Gustavo, B. and C. Vincenza, 2000. Intracellular calcium homeostasis and signaling in trypanosomatids. Elect. J. Path History, 6 (1): 423-426.
12. Gyamfi, M.A., M. Yonamine and Y. Aniya, 1999. Free radical scavenging action of medicinal herbs from Ghana: Thomingia sangulnea on experimentally induced liver injiries. Gen. Pharmacol., 32 (6): 661-667.
13. Hoet, S., Opperdoes, B. Brun and J. Quetin-Leclereq, 2004. Natural products active against African trypanosomes: A step towards new drugs. Nat. Prod. Rep., 21 (3): 353-364.
14. Hool, L.C. and B. Corry, 2007. Radox control of calcium channels: From mechanism to therapeutic opportunities. Antioxidants and Redox Signaling, 9 (4): 409-435.
15. Kagira, J., J.K. Thuita, M. Ngotho, R. Ndachi, D.M. Mwangangi and J.M. Ndung'u, 2006. Heamatology of experimental Trypanosoma rhodesiense infection in vervet monkeys. Afr. J. Health Sci., 13 (3-4): 59-65.
16. Ledwaba, M.F. and K.D. Roberson, 2003. Effectiveness of Twenty-five hydroxycholecalciferol in prevention of Tibial dyschondroplasia in Ross cockrels depends on dietary calcium level. Poult. Sci. 82 (11): 1769-1777.
17. Maldonado, R.A., S. Mirzoera, L.M. Godsel, T.J. Lukas, S. Goldenberg, D.M. Watterson and D. Egman, 1999. Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch proteins. [ABST] www.ncbi.nlm.nih.gov/pubmed.
18. Matsumoto, K., LT. Yamamoto, K. Watanabe, S. Yano, J. Shan, P.K.T. Pang, H. Takayama and S. Horie, 2005. Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens. Life Sci., 78 (2): 187-194.
19. Mishina, Y.V., S. Krishna, R.K. Haynes and J.C. Meade, 2007. Artemisinin inhibits Trypanosomal cruzi and Trypanosoma brucei rhodensiense in vitro growth. Antimicrob. Agents Chemother., 51 (15): 1852-1854.
20. Mottram, J.C. and G.H. Coombs, 1999. Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. Trends Microbiol., 7 (2): 82-87.
21. Moura, K.C.G., F.S. Emery, C. Pinto-Neves, F.R.M. Pinto, A.P. Dantas, K. Saloma, S.L. Castro and A.V. Pinto, 2001. Trypanocidal activity of isolated naphthaquinones from Tabebuia and some heterocyclic derivatives: A review from an interdisplinary study. J. Braz. Chem. Soc., 12 (3): 325-338.
22. Naessens, J., H. Kitani, Y. Nakamura, Y. Yagi, Sekikawa and F. Iraq, 2005. TNF-a mediated the development of anaemia in a murine Trypanosome brucei rhodensiense infection, but not the anemia associated with a murine trypanosome congolense infection. Clin Exp. Immunol., 139 (3): 405-410.
23. Nikolskaia, O.U., A.P.C. Lima, Y.V. Kim, J.D. Lonsdal-Eccles, T. Fukuma, B. Scarfstein and D.J. Grab, 2006. Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease. J. Clin. Invest., 116 (10): 2739-2747.
24. Ogbunugafor, H.A., V.I. Okochi, J. Okpuzor, S. Ogbonna and P. Emeka, 2005. Antitrypanosomal activity of Mitragyna ciliata and Ritchea longipedicellata. Society for Medicinal Plant Research (GA). 53rd Annual Meeting and International Congress, Florence, pp: 171.
25. Ogbunugafor, H.A., V.I. Okochi, J. Okpuzor, S. Esue and T. Adedayo, 2007. Mitragyna ciliata and its trypanocidal activity. Afr. J. Biotechnol., 6 (20): 2303-2309.
26. Scovil, J., E. Blank, M. Konnick E. Nenortas and T. Shapiro, 2001. Antitrypanosomal activities of tryptanthrins. Antimicrob. Agents Chemother., 46(3): 882.
27. TDR, 2005. Making health research for poor people. Seventeenth Programme Progress Report, 2003-2005.
28. WHO, 2000. Report on global surveillance of epidemic-prone infectious disease. www.who.int/osr/resources/publications/surveillance/s_tryps.
29. Wu, J., Y. Tung, S. Wang, L. Shyur, Y. Kwo and S. Chang, 2005. Phenolic antioxidant from the heartwood of Acacia confusa. J. Agric. Food Chem., 53(15): 5917-5921.
30. Wurochekke, A.U. and A.J. Nok, 2004. In vitro antitrypanosomal activity of some medicinal plants used in the treatment of trypanosomiasis in Northern Nigeria. Afr. J. Biotechol., 3 (9): 481-483.