Design and evaluation of ethyl cellulose based matrix tablets of ibuprofen with pH modulated release kinetics

Indian Journal of Pharmaceutical Sciences

Volumn 70, Issue 5, 2008, Pages 596-602

  Chandran, S ^a   Asghar, Laila ^a   Mantha, Neelima ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Cellulose acetate phthalate; Ethyl cellulose; Ibuprofen; Matrix tablet

Indexed keywords

CELLACEFATE; ETHYL CELLULOSE; IBUPROFEN;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DESIGN; DRUG RELEASE; DRUG SOLUBILITY; PH; STOMACH; TABLET;

EID: 60249089466     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.45397     Document Type: Article

References (24)

1. Dhikav V, Sindhu S, Anand KS. Newer non-steroidal anti-inflammatory drugs: A review of their therapeutic potential and adverse drug reactions. J Indian Acad Clinical Med 2002;3:332-8
2. Lain L. Serious lower gastrointestinal clinical events with non-selective NSAIDs and COXIB use. Gastroenterology 2003;124:288-92.
3. Burke A, Smyth EM, FitzGerald GA. Analgesics-Antipyretics and Antiinflammatory agents: Pharmacotherapy of Gout. In: Brunton LL, Lazo KS, Parker KL, editors. The Pharmacological Basis of Therapeutics, 11th ed. New York: McGraw-Hill Professional; 2005. p. 671.
4. Singh G. Recent considerations in non-steroidal anti-inflammatory drug gastropathy. Am J Med 1998;105:31S-8S.
5. Khan GM, Zhu JB. Controlled release coprecipitates of Ibuprofen and Carbopol 934- Preparation, characterization and In vitro release. Sciences 2001;1:355-60.
6. Vueba ML, Batista de Carvalho LA, Veiga F, Sousa JJ, Pina ME. Role of cellulose ether polymers on ibuprofen release from matrix tablets. Drug Develop Ind Pharm 2005;31:653-65.
7. Rekhi GS, Jambekhar SS. Ethylcellulose: A polymer review. Drug Develop Ind Pharm 1995;21:61-77.
8. Vueba ML, Batista de Carvalho LA, Veiga F, Sousa JJ, Pina ME Influence of cellulose ether mixtures on ibuprofen release: MC25, HPC and HPMC K100M. Pharm Dev Technol 2006;11:213-28.
9. Sajeev C, Saha RN. Formulation and comparative evaluation of controlled release diclofenac tablets prepared by matrix- embedding technique, membrane barrier technique and combination of the two. Drug Dev Res 2001;53:1-8.
10. De Brabander C, Vervaet C, Remon JP. Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion. J Control Release 2003;89:235-47.
11. Lopes C, Manuel S, Lobo J, Costa P, Pinto J. Directly compressed mini matrix tablets containing ibuprofen- preparation and evaluation of sustained release. Drug Develop Ind Pharm 2006;32:95-106.
12. Roxin P, Karlsson A, Singh SK. Characterization of cellulose acetate phthalate (CAP). Drug Dev Ind Pharm 1998;24:1025-41.
13. Obeidat WM, Price JC. Evaluation of enteric matrix microspheres prepared by emulsion-solvent evaporation using scanning electron microscopy. J Microencap 2004;21:47-57.
14. Beyger JW, Nairn JG. Some factors affecting the microencapsulation of pharmaceuticals with cellulose acetate phthalate. J Pharm Sci 1986;75:573-8.
15. Silva JP, Ferreira JP. Effect of drug properties on the release from CAP microspheres prepared by a solvent evaporation method. J Microencap 1999;16:95-103.
16. Palmieri GF, Michelini S, Di Martino P, Martelli S. Polymers with pH-dependent solubility: Possibility of use in the formulation of gastroresistant and controlled-release matrix tablets. Drug Develop Ind Pharm 2000;26:837-45.
17. Lindenberg M, Kopp S, Dressman JB. Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. Eur J Pharm Biopharm 2004;58:265-78.
18. Ritger PL, Peppas NA. A simple equation for the description of solute release, I: Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J Control Rel 1987;5:23-36.
19. Saha RN, Sajeev C, Sahoo J. A comparative study of controlled release matrix tablets of diclofenac sodium, ciprofloxacin hydrochloride and theophylline. Drug Deliv 2001;8:149-54.
20. Khan GM, Meidan VK. Drug release kinetics from tablet matrices based upon ethylcellulose ether-derivatives: A comparison between different formulations. Drug Develop Ind Pharm 2007;33:627-39.
21. Nokhodchi A, Zakeri-Milani P, Valizadeh H, Hassan-Zadeh D. Evaluation of microcapsules of acetyl salicylic acid prepared with cellulose acetate phthalate, ethycellulose or their mixtures by an emulsion non-solvent addition technique. Ars Pharmaceutica 2002;43:135-47.
22. Shah PV, Noory A, Noory C, McCullough B, Clarke S, Everett R, et al. In vitro dissolution of a sparingly water soluble drug dosage forms. Int J Pharm 1995;125:99-106.
23. Jamzad S, Fassihi R. Role of surfactant and pH on dissolution properties of fenofibrate and glipizide. AAPS Pharm Sci Tech 2006;7:33.
24. Chen LR, James A, Bhattachar S, Ruiz B, Bahash K, Babu S. Dissolution behavior of a poorly water soluble compound in the presence of tween 80. Pharm Res 2003;20:797-801.