Protective effect of Rinax, a herbal formulation, against CCl4-induced liver injury and survival in rats

Journal of Ethnopharmacology

Volumn 56, Issue 2, 1997, Pages 159-164

  Dhuley, J N ^a   Naik, S R ^a  

^a Hindustan Antibiotics Ltd   (India)

Author keywords

CCl4; Hepatoprotection; Rats; Rhinax

Indexed keywords

CARBON TETRACHLORIDE; CYTOCHROME P450; LIVER PROTECTIVE AGENT; ASPARTATE AMINOTRANSFERASE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HERB; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SURVIVAL; ANIMAL; AYURVEDA; BLOOD; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; LIVER; LIVER DISEASE; LIVER MICROSOME; MEDICINAL PLANT; METABOLISM; MORTALITY; PATHOLOGY; RANDOMIZATION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; LIVER; LIVER DISEASES; MALE; MEDICINE, AYURVEDIC; MICROSOMES, LIVER; PLANT EXTRACTS; PLANTS, MEDICINAL; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 0030612504     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(97)01524-9     Document Type: Article

References (18)

1. Barber, A.A. (1963) Addendum: mechanisms of lipid peroxide formation in rat tissue homogenates. Radiation Research 3, 33-43.
2. 4 induced toxicity in isolated hepatocytes, the importance of direct solvent injury. Hepatology 6, 36-45.
3. Bergmeyer, S.U., Buttner, H. and Hillmann, G. (1972) Recommendations of the German society for clinical chemistry standardisation of methods for the estimation of enzyme activities in biological fluids. Zeitschrift Klinische Chemistry Biochemistry 10, 281-288.
4. Buege, J.A. and Aust, S.D. (1977) Microsomal lipid peroxidation. Methods in Enzymology 52, 302-310.
5. Cheng, K.L. and McCay, P.B. (1972) Liposome disruption by a free radical like component generated during microsomal NADPH oxidase activity. Biochemical Biophysical Research Communications 48, 1412-1418.
6. 4 liver cell injury. Archives of Biochemistry and Biophysics 264, 561-599.
7. Fong, F.L., McCay, P.B., Poyer, L., Keele, B.B. and Misra, R.R. (1973) Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavine enzyme activity. Journal of Biological Chemistry 248, 7792 -7797.
8. Goeptar, A.R., Scheerens, H. and Vermeulen, N.P.E. (1995) Oxygen and xenobiotic reductase activities of cytochrome P450. Critical Reviews of Toxicology 25, 25-65.
9. Halpert, J.R., Guengerich, F.P., Bend, J.R. and Correia, M.A. (1994) Contemporary issues in toxicology. Selective inhibitors of cytochromes P450. Toxicology and Applied Pharmacology 125, 163-175.
10. Johansson, I. and Ingleman-Sundberg, M. (1985) Carbon tetrachloride induced lipid peroxidation dependent on an ethanol inducible form of rabbit liver microsomal cytochrome P450. Federation of European Biochemical Societies Letters 183, 265-269.
11. Koop, D.R. (1992) Oxidative and reductive metabolism by cytochrome P450 2E1. Federation of the American Societies for Experimental Biology Journal 6, 724-730.
12. Kornbrust, D.J. and Mavis, R.D. (1980) Microsomal lipid peroxidation II. Stimulation by carbon tetrachloride. Molecular Pharmacology 17, 408-414.
13. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin-phenol reagent. Journal of Biological Chemistry 193, 265-275.
14. Marini-Bettolo, G.B. (1980) Present aspects of the use of medicinal plants in traditional medicine. Journal of Ethnopharmacology 2, 5-7.
15. Omura, T. and Sato, R. (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry 239, 2370-2378.
16. Recknagel, R.O., Glende, E.A., Dolak, J.A. and Waller, R.L. (1989) Mechanisms of carbon tetrachloride toxicity. Pharmacology and Therapeutics 43, 139-154.
17. Uehleke, H., Hellmer, K.H. and Tabarelli, S. (1973) Binding of carbon-14-labeled-carbon tetrachloride to microsomal proteins in-vitro and formation of chloroform by reduced liver microsomes. Xenobiotica 3, 1-11.
18. Yamazoe, Y., Kamataki, T. and Kato, R. (1981) Species difference in N-hydroxylation of a tryptophan pyrolysis product in relation to mutagenic activation. Cancer Research 41, 4518-4523.