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60149111673
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note
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The reaction of 1a and 2a also produced 5a without Pd catalyst, however, the yield was lower (51%) and required long time (10 h) at higher temperature (110 °C). The explanation on the mechanism of the last step, dealkoxycarbonylation and concomitant aerobic oxidation, is not clear at this stage and needs further study.
-
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34
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33845783704
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For the introduction of active methylene compounds at the primary position of Baylis-Hillman adducts and their synthetic applications, see
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60149100748
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note
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°C).
-
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37
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60149105927
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note
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Compound 5a was also generated from 4a without the influence of Pd catalyst in a similar yield (63%). The results state that the last step is a base-mediated process not Pd-mediated one, actually.
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39
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