Report of the working group 'Overall blood supply strategy with regard to variant Creutzfeldt-Jakob disease (vCJD)': Statement on the development and implementation of test systems suitable for the screening of blood donors for vCJD - Dated September 17, 2008

Transfusion Medicine and Hemotherapy

Volumn 36, Issue 1, 2009, Pages 79-93

  Seitz, Rainer ^a   Beekes, Michael ^b   Blümel, Johannes ^a   Burger, Reinhard ^b   Von Dewitz, Christian ^c   Gröner, Albrecht ^d   Heiden, Margarethe ^a   Kretzschmar, Hans ^e   Nübling, Micha ^a   Schlenkrich, Uwe ^f   Schottstedt, Volkmar ^g   Strobel, Johanna ^h   Willkommen, Hannelore ⁱ   Von König, Erkrath Carl Heinz Wirsing ^j   Zerr, Inga ^k  

^a PAUL EHRLICH INSTITUT   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

^c State Office of Health and Social Affairs (LaGeSo)   (Germany)

^d CSL BEHRING GMBH   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f German Hemophilia Society (DHG)   (Germany)

^g Blood Services of the German Red Cross West (DRK)   (Germany)

^h Federal Ministry of Health   (Germany)

ⁱ Regulatory Affairs and Biological Safety Consulting   (Germany)

^j HELIOS Clinical Center   (Germany)

^k UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID;

BLOOD DONOR; BLOOD TRANSFUSION; CLINICAL FEATURE; DIAGNOSTIC PROCEDURE; DISEASE TRANSMISSION; HUMAN; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; PATHOPHYSIOLOGY; PHENOTYPE; PRION; REVIEW; SCREENING TEST; SPECTROSCOPY; VARIANT CREUTZFELDT JAKOB DISEASE; WESTERN BLOTTING;

EID: 60149084071     PISSN: 16603796     EISSN: None     Source Type: Journal    
DOI: 10.1159/000188082     Document Type: Review

References (56)

1. Joint press release of the Paul-Ehrlich-Institut and the Robert Koch-Institut. Gesamtstrategie Blutversorgung im Angesicht der BSE-Krise. www.pei.de/cln-115/nn-157198/DE/infos/presse/pm/archiv/2001/14.html.
2. Working Group 'Overall Blood Supply with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)': Overall Blood Supply with Regard to Variant Creutzfeldt-Jakob Disease (vCJD) - Report of the Working Group Commissioned by the German Federal Ministry of Health, April 13, 2006 (Update of the Report from August 17, 2001). Transfus Med Hemother 2006:33(suppl 2).
3. Seitz R, von Auer F, Blümel J, Burger R, Buschmann A, Dietz K, Heiden M, Hitzler WE, Klamm H, Kreil T, Kretzschmar H, Nübling M, Offergeld R, Pauli G, Schottstedt V, Volkers P, Zerr I: Impact of vCJD on blood supply. Biologicals 2007;35:79-97.
4. Creutzfeldt HG: Über eine eigenartige herdförmige Erkrankung des Zentralnervensystems. Z Ges Neurol Psychiatr 1920;57:1-18.
5. Jakob A: Über eigenartige Erkrankungen des Zentralnervensystems mit bemerkenswertem anatomischem Befund (Spastische Pseudosklerose - Encephalomyelopathie mit disseminierten Degenerationsherden). Dtsch Z Nervenheilk 1921;70:132-146.
6. Glatzel M, Abela E, Maissen M, Aguzzi A: Extraneural pathogenic prion protein in sporadic Creutzfeldt-Jakob disease. N Engl J Med 2003;349:1812-1820.
7. Bishop MT, Ritchie DL, Will RG, Ironside JW, Head MW, Thomson V, Bruce M, Manson JC: No major change in vCJD agent strain after secondary transmission via blood transfusion. PLoS ONE 2008;3:1-6.
8. The National Creutzfeldt-Jakob Disease Surveillance Unit (NCJDSU): Variant Creutzfeldt-Jakob Disease. Current data. www.cjd.ed.ac.uk/vcjdworld. htm.
9. Dietz K, Raddatz G, Wallis J, Müller N, Zerr I, Duerr H-P, Lefèvre H, Seifried E, Löwer J:. Blood transfusion and spread of variant Creutzfeldt-Jakob disease. Emerg Infect Dis 2007;13:89-96.
10. Clarke P, Will RG, Ghani AC: Is there the potential for an epidemic of variant Creutzfeldt-Jakob disease via blood transfusion in the UK? J R Soc Interface 2007;4:675-684.
11. Garske T: Presentation at the Paul-Ehrlich-Institut on May 28, 2008.
12. Mead S, Joiner S, Desbruslais M, Beck JA, O'Donoghue M, Lantos P, Wadsworth JDF, Collinge J: Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrPSc type in a young British woman. Arch Neurol 2007;64:1780-1784.
13. Coghlan A: Mysterious death reignites vCJD fears. NewScientist 2008;2637:11.
14. Gambetti P, Dong Z, Yuan J, et al: A novel human disease with abnormal prion protein sensitive to protease. Ann Neurol 2008;63:697-708.
15. Krebs B, Bader B, Klehmet J, Grasbon-Frodl E, Oertel WH, Zerr I, Stricker S, Zschenderlein R, Kretzschmar HA: A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Acta Neuropathol 2007;114:195-199.
16. Parchi P, Giese A; Capellari S, Brown P, Schulz-Schaeffer W, Windl O, Zerr I, Budka H, Kopp N, Piccardo P, Poser S, Rojiani A, Streichemberger N, Julien J, Vital C, Ghetti B, Gambetti P, Kretzschmar H: Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol 1999;46:224-233.
17. Oesch B, Westaway D, Wälchli M, McKinley MP, Kent SBH, Aebersold R, Barry RA, Tempst P, Teplow DB, Hood LE, Prusiner SB, Weissmann C: A cellular gene encodes scrapie PrP(27-30) protein. Cell 1985;40:735-746.
18. Basler K, Oesch B, Scott M, Westaway D, Wälchli M, Groth DF, McKinley MP, Prusiner SB, Weissmann C: Scrapie and cellular PrP isoforms are encoded by the same chromosomal gen. Cell 1986;46:417-428.
19. Caughey BW, Dong A, Bhat KS, Ernst D, Hayes SF, Caughey WS: Secondary structure analysis of the scrapie-associated protein PrP(27-30) in water by infrared spectroscopy. Biochemistry 1991;30:7672-7680.
20. Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE, Prusiner SB: Conversion of alpha-helices into beta-sheets features the formation of the scrapie prion proteins. Proc Natl Acac Sci U S A 1993;90:10962-10966.
21. Safar J, Wille H, Itri V, Groth D, Serban H, Torchia M, Cohen FE, Prusiner SB: Eight prion strains have PrPSc molecules with different conformations. Nat Med 1998;4:1157-1165.
22. Kascsak RJ, Rubenstein R, Merz PA, Tonna-DeMasi M, Fersko R, Carp RI, Wisniewski HM, Diringer H: Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol 1987;61:3688-3693.
23. Barry RA, Prusiner SB: Monoclonal antibodies to the cellular and scrapie prion protein. J Infect Dis 1986;154:518-521.
24. Korth C, Stierli B, Streit P, Moser M, Schaller O, Fischer R, Schulz-Schaeffer W, Kretzschmar H, Raeber A, Braun U, Ehrensperger F, Hornemann S, Gluckshuber R, Riek R, Billeter M, Wüthrich K, Oesch B: Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature 1997;390:74-77.
25. Moroncini G, Mangieri M, Morbin M, Mazzoleni G, Ghetti B, Gabrielli A, Williamson RA, Giaccone G, Tagliavini F: Pathogenic prion protein is specifically recognized in situ by a novel PrP conformational antibody. Neurobiol Dis 2006;23:717-724.
26. Ulrih NP, Skrt M, Veranic P, Galvani V, Vranac T, Curin Serbec V: Oligomeric forms of peptide fragments PrP(214-226) in solution are preferentially recognized by PrPSc-specific antibody. Biochem Biophys Res Commun 2006;344:1320-1326.
27. Salguero FJ, Diaz-San Segundo F, Brun A, Cano MJ, Torres JM: Comparison of three monoclonal antibodies for use in immunohistochemical detection of bovine spongiform encephalopathy protease-resistant prion protein. J Vet Diagn Invest 2006;18:106-109.
28. Biasini E, Seegulam ME, Patti BN, Solforosi L, Medrano AZ, Christensen HM, Senatore A, Chiesa R, Williamson RA, Harris DA: Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies. J Neurochem 2008;105:2190-2204.
29. Morel N, Simion S, Frobert Y, Volland H, Mourton-Gilles C, Negro A, Sorgato MC, Creminon C, Grassi J: Selective and efficient immunoprecipitation of the disease-associated form of the prion protein can be mediated by non-specific interactions between monoclonal antibodies and scrapie-associated fibrils. J Biochem Chem 2004;279:30143-30149.
30. Pan T, Li R, Wong B-S, Kang S-C, Ironside J, Sy M-S: Novel antibody-lectin enzyme-linked immunosorbent assay that distinguishes prion proteins in sporadic and variant cases of Creutzfeldt-Jakob disease. J Clin Microbiol 2005;43:1118-1126.
31. Safar JG, Geschwind MD, Deering C, Didorenko S, Sattavat M, Sanchez H, Serban A, Vey M, Baron H, Giles K, Miller BL, DeArmond SJ: Diagnosis of human prion disease. Proc Natl Acad Si U S A 2005;102:3501-3506.
32. Bessen RA, Marsh RF: Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent. J Virol 1992;66:2096-2101.
33. Barron RM, Campbell SL, King D, Bellon A, Chapman KE, Williamson RA, Manson JC: High titers of transmissible spongiform encephalopathy infectivity associated with extremly low levels of PrPSc in vivo. J Biol Chem 2007;282:35878-35886.
34. Berardi VA, Cardone F, Valanzano A, Lu M, Pocchiari M: Preparation of soluble infectious samples from scrapie-infected brain: new tool to study the clearance of transmissible spongiform encephalopathy agents during plasma fractionation. Transfusion 2006;46:652-658.
35. Wadsworth JDF, Joiner S, Hill AF, Campbell TA, Desbruslais M, Luthert PJ, Collinge J: Tissue distribution of protein resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet 2001;358:171-180.
36. Silveira JR, Raymond GJ, Hughson AG, Race RE, Sim VL, Hayes SF, Caughey B: The most infectious prion protein particle. Nature 2005;437:257-261.
37. Brown P, Rohwer RG, Dunstan BC, MacAuley C, Gajdusek DC, Drohan WN: The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy. Transfusion 1998;38:810-816.
38. Brown P, Cervenáková L, McShane LM, Barber P, Rubenstein R, Drohan WN: Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans. Transfusion 1999;39:1169-1178.
39. Cervenáková L, Yakovleva O, McKenzie C, Kolchinski S, McShane L, Drohan WN, Brown P: Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy. Transfusion 2003;43:1687-1694.
40. Houston F, Foster JD, Chong A, Hunter N, Bostock CJ: Transmission of BSE by blood transfusion in sheep. Lancet 2000;356:999-1000.
41. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, Eaton S, MacKenzie C, Houston F: Transmission of prion diseases by blood transfusion. J Gen Virol 2002;83:2897-2905.
42. Yakovleva O, Janiak A, McKenzie C, McShane L, Brown P, Cervenáková L: Effect of protease treatment on plasma infectivity in variant Creutzfeldt-Jakob disease mice. Transfusion 2004;44:1700-1705.
43. Minor P: NIBSC, presentation at the workshop of the European Commission on 26 October 2007 in Brussels.
44. Uger M: Amorfix Life Sciences, presentation at the workshop of the European Commission on 26 October 2007 in Brussels.
45. Health Protection Agency: TED-Publication 30072-2007, February 6, 2007.
46. Pan T, Sethi J, Nelsen C, Rudolph A, Cervenáková L, Brown P, Orser CS: Detection of misfolded prion protein in blood with conformationally sensitive peptides. Transfusion 2007;47:1418-1425.
47. Saborio GP, Permanne B, Soto C: Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 2001;411:810-813.
48. Atarashi R, Moore RA, Sim VL, Hughson AG, Dorward DW, Onwubiko HA, Priola SA, Caughey B: Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods 2007;4:645-650.
49. Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM, Onwubiko HA, Priola SA, Caughey B: Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods 2008;5:211-212;
50. Colby DW, Zhang Q, Wang S, Groth D, Legname G, Riesner D, Prusiner SB: Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A 2007;104:20914-20919.
51. Mahal SP, Baker CA, Demczyk CA, Smith EW, Julius C, Weissmann C: Prion strain discrimination in cell culture: the cell panel assay. Proc Natl Acad Sci U S A 2007;104:20908-20913.
52. Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, Aguzzi A: A versatile prion replication assay in organotypic brain slices. Nat Neurosci 2008;11:109-117.
53. Fagge TJ, Barclay GR, Stove GC, Stove G, Robinson MJ, Head MW, Ironside JW, Turner ML: Application of atomic dielectric resonance spectroscopy for the screening of blood samples from patients with clinical variant and sporadic CJD. J Transl Med 2007;5:41.
54. Directive 98/79/EG of the European Parliament and of the Council of 27 October 1998 on in vitro diagnostic medical devices. Official Journal of the European Communities L 331/1 of December 7, 1998.
55. Amorfix: Press Release of August 19, 2008.
56. Haschberger B, Henseler O, Hesse J, Heiden M, Seitz R: Bericht zur Meldung nach § 21 TFG für die Jahre 2005 und 2006. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 2008;51:353-372.